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Citation
Slankster, E., Kollala, S., Baria, D., Dailey-Krempel, B., Jain, R., Odell, S.R., Mathew, D. (2020). Mechanism underlying starvation-dependent modulation of olfactory behavior in Drosophila larva.  Sci. Rep. 10(1): 3119.
FlyBase ID
FBrf0244933
Publication Type
Research paper
Abstract

Starvation enhances olfactory sensitivity that encourage animals to search for food. The molecular mechanisms that enable sensory neurons to remain flexible and adapt to a particular internal state remain poorly understood. Here, we study the roles of GABA and insulin signaling in starvation-dependent modulation of olfactory sensory neuron (OSN) function in the Drosophila larva. We show that GABAB-receptor and insulin-receptor play important roles during OSN modulation. Using an OSN-specific gene expression analysis, we explore downstream targets of insulin signaling in OSNs. Our results suggest that insulin and GABA signaling pathways interact within OSNs and modulate OSN function by impacting olfactory information processing. We further show that manipulating these signaling pathways specifically in the OSNs impact larval feeding behavior and its body weight. These results challenge the prevailing model of OSN modulation and highlight opportunities to better understand OSN modulation mechanisms and their relationship to animal physiology.

PubMed ID
PubMed Central ID
PMC7033209 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference
    Alleles (5)
    Genes (17)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (5)