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Yang, X., Han, Y., Mu, Y., Yang, P., Gu, W., Zhang, M. (2020). Multigenerational effects of cadmium on the lifespan and fertility of Drosophila melanogaster.  Chemosphere 245(): 125533.
FlyBase ID
FBrf0244965
Publication Type
Research paper
Abstract

Although the damage and tolerance mechanisms of Cd stress are known, the data on genetic risk are limited. The aim of this study was to assess the chronic toxicity of Cd, genetic responses, and multigenerational effects in five generations of Drosophila melanogaster. For each generation, lifespan and fertility were statistically analysed and the expression of apoptosis- (p53 and caspase-3) and epigenesis-related (dDnmt2 and dMBD2/3) genes was examined. Lifespan and fertility significantly declined under Cd stress and these effects were maintained for two generations and one generation, respectively, when Cd stress was removed. The expression of p53 and caspase-3 was significantly up-regulated after exposure, suggesting that apoptosis contributes to the resistance mechanism. Their altered expression was retained for two generations. Furthermore, high expression of dDnmt2 and dMBD2/3 accompanied Cd exposure, which was passed on to three generations, suggesting that genetic modifications in apoptosis-related genes are carried to the offspring through epigenetic regulation.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Chemosphere
    Title
    Chemosphere
    Publication Year
    1972-
    ISBN/ISSN
    0045-6535
    Data From Reference
    Genes (4)