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Citation
Chang, Y.C., Wu, J.W., Wang, C.W., Jang, A.C. (2019). Hippo Signaling-Mediated Mechanotransduction in Cell Movement and Cancer Metastasis.  Front. Mol. Biosci. 6(): 157.
FlyBase ID
FBrf0244982
Publication Type
Review
Abstract

The evolutionarily conserved Hippo kinase signaling cascade governs cell proliferation, tissue differentiation and organ size, and can promote tumor growth and cancer metastasis when dysregulated. Unlike conventional signaling pathways driven by ligand-receptor binding to initiate downstream cascades, core Hippo kinases are activated not only by biochemical cues but also by mechanical ones generated from altered cell shape, cell polarity, cell-cell junctions or cell-extracellular matrix adhesion. In this review, we focus on recent advances showing how mechanical force acts through the actin cytoskeleton to regulate the Hippo pathway during cell movement and cancer invasion. We also discuss how this force affects YAP-dependent tissue growth and cell proliferation, and how disruption of that homeostatic relationship contributes to cancer metastasis.

PubMed ID
PubMed Central ID
PMC7025494 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Front. Mol. Biosci.
    Title
    Frontiers in molecular biosciences
    ISBN/ISSN
    2296-889X
    Data From Reference
    Genes (14)
    Human Disease Models (1)