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Citation
Koranteng, F., Cha, N., Shin, M., Shim, J. (2020). The Role of Lozenge in Drosophila Hematopoiesis.  Mol. Cells 43(2): 114--120.
FlyBase ID
FBrf0245003
Publication Type
Review
Abstract

Drosophila hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of Drosophila genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determination of prohemocytes into a special class of hemocyte, namely the crystal cell, and discuss molecules and signals controlling the lozenge function and its implication in immunity and stress response. Given the highly conserved nature of Runt domain in both invertebrates and vertebrates, studies in Drosophila will enlighten our perspectives on Runx-mediated development and pathologies.

PubMed ID
PubMed Central ID
PMC7057836 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Cells
    Title
    Molecules and Cells
    ISBN/ISSN
    1016-8478
    Data From Reference
    Genes (15)