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Citation
Gospodaryov, D.V., Strilbytska, O.M., Semaniuk, U.V., Perkhulyn, N.V., Rovenko, B.M., Yurkevych, I.S., Barata, A.G., Dick, T.P., Lushchak, O.V., Jacobs, H.T. (2020). Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila.  Biogerontology 21(2): 155--171.
FlyBase ID
FBrf0245038
Publication Type
Research paper
Abstract

Mitochondrial alternative NADH dehydrogenase (aNDH) was found to extend lifespan when expressed in the fruit fly. We have found that fruit flies expressing aNDH from Ciona intestinalis (NDX) had 17-71% lifespan prolongation on media with different protein-tocarbohydrate ratios except NDX-expressing males that had 19% shorter lifespan than controls on a high protein diet. NDX-expressing flies were more resistant to organic xenobiotics, 2,4-dichlorophenoxyacetic acid and alloxan, and inorganic toxicant potassium iodate, and partially to sodium molybdate treatments. On the other hand, NDX-expressing flies were more sensitive to catechol and sodium chromate. Enzymatic analysis showed that NDX-expressing males had higher glucose 6-phosphate dehydrogenase activity, whilst both sexes showed increased glutathione S-transferase activity.

PubMed ID
PubMed Central ID
PMC7056681 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biogerontology
    Title
    Biogerontology
    Publication Year
    2000-
    ISBN/ISSN
    1389-5729
    Data From Reference
    Alleles (2)
    Genes (6)
    Transgenic Constructs (2)