Open Close
Reference
Citation
Eritano, A.S., Bromley, C.L., Bolea Albero, A., Schütz, L., Wen, F.L., Takeda, M., Fukaya, T., Sami, M.M., Shibata, T., Lemke, S., Wang, Y.C. (2020). Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding.  Dev. Cell 53(2): 212--228.e12.
FlyBase ID
FBrf0245675
Publication Type
Research paper
Abstract

Morphological constancy is universal in developing systems. It is unclear whether precise morphogenesis stems from faithful mechanical interpretation of gene expression patterns. We investigate the formation of the cephalic furrow, an epithelial fold that is precisely positioned with a linear morphology. Fold initiation is specified by a precise genetic code with single-cell row resolution. This positional code activates and spatially confines lateral myosin contractility to induce folding. However, 20% of initiating cells are mis-specified because of fluctuating myosin intensities at the cellular level. Nevertheless, the furrow remains linearly aligned. We find that lateral myosin is planar polarized, integrating contractile membrane interfaces into supracellular "ribbons." Local reduction of mechanical coupling at the "ribbons" using optogenetics decreases furrow linearity. Furthermore, 3D vertex modeling indicates that polarized, interconnected contractility confers morphological robustness against noise. Thus, tissue-scale mechanical coupling functions as a denoising mechanism to ensure morphogenetic precision despite noisy decoding of positional information.

PubMed ID
PubMed Central ID
Related Publication(s)
Note

When the Community Silences Disruptive Elements: Multiscale Mechanical Coupling Buffers Morphogenetic Imprecisions.
Martin and Suzanne, 2020, Dev. Cell 53(2): 135--137 [FBrf0245742]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference