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Citation
Li, Q., DeBeaubien, N.A., Sokabe, T., Montell, C. (2020). Temperature and Sweet Taste Integration in Drosophila.  Curr. Biol. 30(11): 2051--2067.e5.
FlyBase ID
FBrf0245907
Publication Type
Research paper
Abstract

Sugar-containing foods offered at cooler temperatures tend to be less appealing to many animals. However, the mechanism through which the gustatory system senses thermal input and integrates temperature and chemical signals to produce a given behavioral output is poorly understood. To study this fundamental problem, we used the fly, Drosophila melanogaster. We found that the palatability of sucrose is strongly reduced by modest cooling. Using Ca2+ imaging and electrophysiological recordings, we demonstrate that bitter gustatory receptor neurons (GRNs) and mechanosensory neurons (MSNs) are activated by slight cooling, although sugar neurons are insensitive to the same mild stimulus. We found that a rhodopsin, Rh6, is expressed and required in bitter GRNs for cool-induced suppression of sugar appeal. Our findings reveal that the palatability of sugary food is reduced by slightly cool temperatures through different sets of thermally activated neurons, one of which depends on a rhodopsin (Rh6) for cool sensation.

PubMed ID
PubMed Central ID
PMC7329267 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Temperature and Sweet Taste Integration in Drosophila.
Li et al., 2020, Curr. Biol. 30(11): 2207--2209 [FBrf0245983]

Personal communication to FlyBase

Location data for Rh5[LexA] deletion.
Li and Montell, 2020.12.4, Location data for Rh5[LexA] deletion. [FBrf0247499]

Note

A fly rhodopsin sheds light on thermal taste.
Stanley et al., 2020, Cell Calcium 91: 102259 [FBrf0246840]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference