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Citation
Dai, W., Guo, X., Cao, Y., Mondo, J.A., Campanale, J.P., Montell, B.J., Burrous, H., Streichan, S., Gov, N., Rappel, W.J., Montell, D.J. (2020). Tissue topography steers migrating Drosophila border cells.  Science 370(6519): 987--990.
FlyBase ID
FBrf0247295
Publication Type
Research paper
Abstract

Moving cells can sense and respond to physical features of the microenvironment; however, in vivo, the significance of tissue topography is mostly unknown. Here, we used Drosophila border cells, an established model for in vivo cell migration, to study how chemical and physical information influences path selection. Although chemical cues were thought to be sufficient, live imaging, genetics, modeling, and simulations show that microtopography is also important. Chemoattractants promote predominantly posterior movement, whereas tissue architecture presents orthogonal information, a path of least resistance concentrated near the center of the egg chamber. E-cadherin supplies a permissive haptotactic cue. Our results provide insight into how cells integrate and prioritize topographical, adhesive, and chemoattractant cues to choose one path among many.

PubMed ID
PubMed Central ID
PMC8103818 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference