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Citation
Wu, Y., Funato, Y., Meschi, E., Jovanoski, K.D., Miki, H., Waddell, S. (2020). Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory.  eLife 9(): e61339.
FlyBase ID
FBrf0247921
Publication Type
Research paper
Abstract

Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg2+ feeding also enhances long-term memory in Drosophila. Normal and Mg2+-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg2+-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg2+. We propose that regulated neuronal Mg2+ efflux is critical for normal and Mg2+-enhanced memory.

PubMed ID
PubMed Central ID
PMC7843133 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for uex[Delta].
Wu and Waddell, 2021.7.19, Location data for uex[Delta]. [FBrf0249519]

Note

A divalent boost from magnesium.
Laursen and Garrity, 2021, eLife 10: e65359 [FBrf0248020]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference