Cornelio-Parra, D.V., Goswami, R., Costanzo, K., Morales-Sosa, P., Mohan, R.D. (2021). Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module. Biochim Biophys Acta Gene Regul Mech 1864(2): 194630.
FlyBase ID
FBrf0248696
Publication Type
Review
Abstract
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex is a critical regulator of gene expression and is highly conserved across species. Subunits of SAGA arrange into discrete modules with lysine aceyltransferase and deubiquitinase activities housed separately. Mutation of the SAGA deubiquitinase module can lead to substantial biological misfunction and diseases such as cancer, neurodegeneration, and blindness. Here, we review the structure and functions of the SAGA deubiquitinase module and regulatory mechanisms acting to control these.
