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Citation
Cohen, E., Peterson, N.G., Sawyer, J.K., Fox, D.T. (2021). Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut.  Dev. Cell 56(14): 2059--2072.e3.
FlyBase ID
FBrf0249634
Publication Type
Research paper
Abstract

Individual organ development must be temporally coordinated with development of the rest of the organism. As a result, cell division cycles in a developing organ occur on a relatively fixed timescale. Despite this, many developing organs can regenerate cells lost to injury. How organs regenerate within the time constraints of organism development remains unclear. Here, we show that the developing Drosophila hindgut regenerates by accelerating the mitotic cell cycle. This process is achieved by decreasing G1 length and requires the JAK/STAT ligand unpaired-3. Mitotic capacity is then terminated by the steroid hormone ecdysone receptor and the Sox transcription factor Dichaete. These two factors converge on regulation of a hindgut-specific enhancer of fizzy-related, a negative regulator of mitotic cyclins. Our findings reveal how the cell-cycle machinery and cytokine signaling can be adapted to accomplish developmental organ regeneration.

PubMed ID
PubMed Central ID
PMC8319103 (PMC) (EuropePMC)
Related Publication(s)
Note

Racing against the clock: How flies regenerate just in time.
Box and Buttitta, 2021, Dev. Cell 56(14): 2012--2013 [FBrf0249802]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference