Cell Line Kc167 Kc167

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General Information
Symbol	Kc167	Species	D. melanogaster
Feature type	cultured cell-line	FlyBase ID	FBtc0000001

Source	e/se
Tissue Source
Developmental Stage	dorsal closure stage
Lab of Origin	Goldschmidt-Clermont (Cherbas et al., 1988)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Characterization
Sex	female (based on roX expression)
Karyotype
Integrated constructs ( 0 )

Comments
	Expression of cell-type specific markers correlates with that of plasmatocytes. (Cherbas et al., 2011) RNA-Seq transcription profile for this cell line may be found at GEO: GSE15596 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15596) and GEO: GSE18040 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18040). See also the FlyBase collection report modENCODE_mRNA-Seq_cell.A (FBlc0000116) and FlyBase RNA-Seq GBrowse view. (Cherbas et al., 2011) Expression profiling by genome tiling array for this cell line may be found at GEO: GSE16273 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16273). (Cherbas et al., 2011)
Parental Lines ( 1 )
	Cloned from: Kc
Descendent Lines ( 1 )
	Targeted mutant of Kc167: L57-3-11
External Stocks and Resources ( 1 )
	DGRC - Stock center for Drosophila cDNAs, vectors, and cell lines • 1
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Kc (Cherbas et al., 2011) Kc167 (Cherbas et al., 2011)
Secondary FlyBase IDs

References ( 15 )
Research paper	Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Bandura et al., 2005, Curr. Biol. 15(8): 755--759 humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. [FBrf0187297] Belyakin et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(23): 8269--8274 Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories. [FBrf0188251] Bianchi-Frias et al., 2004, PLoS Biol. 2(7): e178 Hairy transcriptional repression targets and cofactor recruitment in Drosophila. [FBrf0179136] Kiger et al., 2003, J. Biol. 2(4): 27 A functional genomic analysis of cell morphology using RNA interference. [FBrf0167741] Neal et al., 2003, Genome 46(5): 879--892 Construction of a cDNA-based microarray for Drosophila melanogaster: a comparison of gene transcription profiles from SL2 and Kc167 cells. [FBrf0167687] Lynch and Maniatis, 1996, Genes Dev. 10(16): 2089--2101 Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. [FBrf0089731] Cherbas et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85: 2096--2100 26-¹²⁵I-iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors. [FBrf0048919] Bourouis and Jarry, 1983, EMBO J. 2(7): 1099--1104 Vectors containing a prokaryotic dihydrofolate reductase gene transform Drosophila cells to methotrexate-resistance. [FBrf0039281] Cherbas et al., 1980, Rouxs Arch. Dev. Biol. 189(1): 1--15 The morphological response of Kc-H cells to ecdysteroids: Hormonal specificity. [FBrf0035568] Cherbas et al., 1977, Science 197: 275--277 Induction of acetylcholinesterase activity by -ecdysone in a Drosophila cell line. [FBrf0030741] Echalier and Ohanessian, 1969, C. r. hebd. Seanc. Acad. Sci., Paris D. Sci. nat. 268: 1771--1773 Isolement, en cultures in vitro, de lignees cellulaires diploides de Drosophila melanogaster. [FBrf0020278]
Review	Cherbas and Cherbas, 1998, Roberts, 1998: 319--346 Cell culture. [FBrf0100957]
Personal communication to FlyBase	Cherbas, 2008.11.12, Cell lines from the DGRC. Cell lines from the DGRC. [FBrf0206131]