Cell Line S2R+ S2R+ S2R+

Help Close All Open All

General Information
Symbol	S2R+	Species	D. melanogaster
Feature type	cultured cell-line	FlyBase ID	FBtc0000150

Source	Oregon R
Tissue Source
Developmental Stage	late embryonic stage
Lab of Origin	Schneider (Schneider, 1972)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Characterization
Sex
Karyotype
Integrated constructs ( 0 )

Comments
	Expression of general hemocyte markers observed. (Cherbas et al., 2011) Expression profiling by genome tiling array for this cell line may be found at GEO: GSE16287 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16287). (Cherbas et al., 2011) S2R+ cells express fz and fz2, and respond to the addition of extracellular wg protein by elevating arm protein levels and hyperphosphorylating dsh protein. (Yanagawa et al., 1998)
Parental Lines ( 1 )
	Isolate of: Schneider's-line-2
Descendent Lines ( 5 )
	Transformant of S2R+: S2R+-NPT005 S2R+-NPT017 S2R+-NPT050 S2R+-NPT101 S2R+-SQH-GFP
External Stocks and Resources ( 1 )
	DGRC - Stock center for Drosophila cDNAs, vectors, and cell lines • 150
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	S2 S2R+ (Cherbas et al., 2011, Yanagawa et al., 1998) S2 receptor plus (Yanagawa et al., 1998) Schneider's 2 Schneider's line 2 SL2
Secondary FlyBase IDs

References ( 7 )
Research paper	Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Biyasheva et al., 2004, J. Cell Sci. 117(6): 837--848 Cascade pathway of filopodia formation downstream of SCAR. [FBrf0174813] Kiger et al., 2003, J. Biol. 2(4): 27 A functional genomic analysis of cell morphology using RNA interference. [FBrf0167741] Kunda et al., 2003, Curr. Biol. 13(21): 1867--1875 Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. [FBrf0167406] Yanagawa et al., 1998, J. Biol. Chem. 273(48): 32353--32359 Identification and characterization of a novel line of Drosophila Schneider S2 cells that respond to wingless signaling. [FBrf0105343] Schneider, 1972, J. Embryol. exp. Morphol. 27: 353--365 Cell lines derived from late embryonic stages of Drosophila melanogaster. [FBrf0024118]
Personal communication to FlyBase	Cherbas, 2008.11.12, Cell lines from the DGRC. Cell lines from the DGRC. [FBrf0206131]