Cell Line CME-W1-Cl.8+ CME-W1-Cl.8+

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General Information
Symbol	CME-W1-Cl.8+	Species	D. melanogaster
Feature type	cultured cell-line	FlyBase ID	FBtc0000151

Source
Tissue Source	wing disc
Developmental Stage	third instar larval stage
Lab of Origin	Milner (Peel and Milner, 1990)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Characterization
Sex	male (based on roX expression)
Karyotype
Integrated constructs ( 0 )

Comments
	Shows expression of spatially defined imaginal disc markers typical of cells along A/P boundary of the wing blade, possibly at D/V boundary. (Cherbas et al., 2011) RNA-Seq transcription profile for this cell line may be found at GEO: GSE15596 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15596). See also the FlyBase collection report modENCODE_mRNA-Seq_cell.A (FBlc0000116) and FlyBase RNA-Seq GBrowse view. (Cherbas et al., 2011) Expression profiling by genome tiling array for this cell line may be found at GEO: GSE16271 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16271). (Cherbas et al., 2011)
Parental Lines ( 1 )
	Cloned from: CME-W1
Descendent Lines ( 1 )
	Selected from CME-W1-Cl.8+: CME-W1-Cl.8R
External Stocks and Resources ( 1 )
	DGRC - Stock center for Drosophila cDNAs, vectors, and cell lines • 151
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Cl.8 (Cherbas et al., 2011) cl.8+ clone8 CME_W1_Cl.8+ (Graveley et al., 2010.03.15) CME-W1-Cl.8+ (Cherbas et al., 2011) CME-W1-cl.8+
Secondary FlyBase IDs

References ( 10 )
Research paper	Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Siviter et al., 2002, Biochem. J. 367(1): 187--193 Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone. [FBrf0151784] Cottam and Milner, 1998, J. Insect Physiol. 44(12): 1137--1144 The effect of juvenile hormone on the response of the Drosophila imaginal disc cell line Cl 8 + to moulting hormone. [FBrf0106365] Aza-Blanc et al., 1997, Cell 89(7): 1043--1053 Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. [FBrf0094081] Yanagawa et al., 1997, J. Biol. Chem. 272(40): 25243--25251 Accumulation of armadillo induced by wingless, dishevelled, and dominant-negative zeste-white 3 leads to elevated DE-cadherin in Drosophila clone 8 wing disc cells. [FBrf0098376] van Leeuwen et al., 1994, Nature 368(6469): 342--344 Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. [FBrf0068757] Peel and Milner, 1990, Rouxs Arch. Dev. Biol. 198(8): 479--482 The diversity of cell morphology in cloned cell lines derived from Drosophila imaginal discs. [FBrf0052924] Currie et al., 1988, Development 102: 805--814 The growth and differentiation in vitro of leg and wing imaginal disc cells from Drosophila melanogaster. [FBrf0047900]
Personal communication to FlyBase	Graveley et al., 2010.03.15, The D. melanogaster transcriptome: modENCODE RNA-Seq data The D. melanogaster transcriptome: modENCODE RNA-Seq data [FBrf0210195] Cherbas, 2008.11.12, Cell lines from the DGRC. Cell lines from the DGRC. [FBrf0206131]