Dmel\INE-1

General Information
Symbol	Dmel\INE-1	Species	D.melanogaster
Name	Interspersed element 1	FlyBase ID	FBte0000312
Feature type	natural transposable element	Created / Updated	2006-12-04/2006-12-04
Sequences & Components
Complete element (bp)
Terminal repeat (bp)
Reference sequence	transposon_sequence_set.embl.txt.gz
Component genes
Sequence Accessions
	DDBJ/EMBL/GenBank X89241 X83271 X62679 X53541 X01918 U66884 J01068 AJ508242 AF025540
Sequence Ontology (SO)
Transposon type	terminal_inverted_repeat_element (Kapitonov and Jurka, 1997-) transposable_element (Kapitonov and Jurka, 1997-, Wilder et al., 2001) SINE_element (Locke et al., 1999)
Insertions & Copy Number
Copy number and comments
Search for	All insertions of this transposon Insertions in the sequenced genome Insertions in other genomes
Target Site Duplication
Size (bp)
Orthologs
Curated drosophilid orthologs	Dsim\INE-1 Dsii\INE-1 (Wilder et al., 2002) Darw\INE-1 (Wilder et al., 2002) Dant\INE-1 (Wilder et al., 2002) Dbdu\INE-1 (Wilder et al., 2002) Damb\INE-1 (Wilder et al., 2001) Dmoj\INE-1 (Wilder et al., 2001) Dacu\INE-1 (Wilder et al., 2002) Dmau\INE-1 Dwil\INE-1 (Holyoake and Kidwell, 2003) Dmad\INE-1 (Wilder et al., 2001) Dprc\INE-1 (Wilder et al., 2002) Dcar\INE-1 (Wilder et al., 2002) Dsub\INE-1 (Wilder et al., 2001) Dmir\INE-1 (Wilder et al., 2001) Dddu\INE-1 (Wilder et al., 2001) Dnec\INE-1 (Wilder et al., 2002) Dbuz\INE-1 (Wilder et al., 2001) Dfun\INE-1 (Wilder et al., 2001) Dcai\INE-1 (Wilder et al., 2002) Dvir\INE-1 (Wilder et al., 2001) Dpmo\INE-1 (Wilder et al., 2002) Dngo\INE-1 (Wilder et al., 2001) Dyak\INE-1
Comments
	"mini-me" elements from separate species show an overall lack of sequence identity but have a number of shared features. Perfect inverted repeats are conserved at both termini of the "mini-me" elements. At the 5' end, the inverted repeat is partially duplicated, forming a complementary palindrome. The 3' inverted repeat is located at a slightly preterminal position. A core 33bp motif that begins approximately 110bp from the 5' end of the element is also conserved, having approximately 80% sequence identity across all copies of the "mini-me" element analysed. A (TA)_n-producing proto-microsatellite is present upstream of the 33bp core region and a (GTCY)_n-producing proto-microsatellite is present downstream of the 33bp core region. The region between the (GTCY)_n proto-microsatellite and the 3' subterminal inverted repeat is not conserved between species and can be extremely variable between copies of "mini-me" elements within a species. INE-1 elements account for approximately 1.2% of the D.melanogaster genome. INE-1 elements are 3 times more abundant on chromosome 4 as in the genome as a whole. (Wilder et al., 2001) INE-1 has a suggested role in the heterochromatic nature of chromosome 4. (Locke et al., 1999) The "Dr. D" repetitive sequence (described in FBrf0048918) contains sequences of both INE-1 and 1360 transposable elements. (Locke et al., 1999) A repeated sequence mostly found on chromosome 4. (Locke et al., 1999) INE-1 elements are distributed throughout the banded region of chromosome 4, at the base of the major chromosome arms, at several telomeres and within the chromocentre. (Locke et al., 1999)
Other Information
Etymology

External Crossreferences
Sequence Crossreferences
	DDBJ/EMBL/GenBank X89241 X83271 X62679 X53541 X01918 U66884 J01068 AJ508242 AF025540
Other Crossreferences

Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	Ars4 ARS312 (Kapitonov and Jurka, 1997-) ars312 ARS320 (Kapitonov and Jurka, 2003) DINE (Wilder and Hollocher, 2000, Locke et al., 1999) DINE-1 (Yang et al., 2006, Hodgetts, 2004, Wilder et al., 2001, Locke et al., 2000, Locke et al., 1999, Locke et al., 1999, Yang et al., 2006, Wang et al., 2007, Yang and Lin, 2007, Steinemann and Steinemann, 2005) DNARep1 (Brennecke et al., 2007) DNAREP1_DM (Kapitonov and Jurka, 2003, Ding et al., 2007) Dr. D (Locke et al., 2000) INE INE1 (Greil et al., 2003) INE-1 (Smith, 2007) Interspersed element 1 (FlyBase, 1996-) mini-me (Wilder et al., 2001, ) narep1 (Celniker et al., 2002, Kapitonov and Jurka, 1997-) Narep1 (Marsano et al., 2003) Narep1/Dine1 (Myster et al., 2004)
Name Synonym	Drosophila Interspersed element 1 Interspersed element 1 Interspersed repeat element (Locke et al., 1999) microsatellite initiating mobile element (Wilder et al., 2001)
Secondary FlyBase IDs
	FBgn0026556 FBgn0000126 FBgn0026416 FBtp0019255
References ( 27 )

Generate a list of	All references relating to this natural transposable element ( 27 )

List References by type	Research paper ( 13 ) Review ( 2 ) Personal communication to FlyBase ( 1 ) Abstract ( 7 ) FlyBase analysis ( 2 ) Computer file ( 1 ) Letter ( 1 )
Recent research papers ( 3 )
	Brennecke et al., 2007, Cell 128(6): 1089--1103 Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. [FBrf0200494] Smith, 2007, Science 316(5831): 1586--1591 [FBrf0202564] Yang et al., 2006, Genetics 173(1): 189--196 Genomewide comparative analysis of the highly abundant transposable element DINE-1 suggests a recent transpositional burst in Drosophila yakuba. [FBrf0192902] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...