|Name||Doc element||FlyBase ID||FBte0000341|
|Feature type||natural transposable element|
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|Sequences & Components|
|Complete element (bp)||
|Terminal repeat (bp)|
|Sequence Ontology (SO)|
|Insertions & Copy Number|
55 in euchromatin of Release 3 genome annotation, of which 30 are full length.
|Target Site Duplication|
|Curated drosophilid orthologs|
The Doc element is transcribed as a full-length 5kb transcript which encodes two open reading frames (ORFs). Doc\gag (ORF1) encodes an RNA-binding protein and Doc\RTase (ORF2) encodes a reverse transcriptase. The RNA is localised on the Drosophila oocyte cytoskeleton.
F-element, I-element and Doc basal promoters share the same architecture and functional organisation.
Changes introduced in the promoter regions of distinct LINEs allows transcriptional activators to stimulate cryptic Inr modules. The response of different promoter constructs to the same enhancer is significantly influenced by the number, position and type of core elements present.
Correlations between the rate of transposition and TE copy number are determined for Doc and are found to be positive.
One of a class of genes with TATA-less promoters that have the conserved DPE sequence.
Distinct cis-acting DNA elements, clustered in a 50bp long DNA region located at the 5' end of unit-length Doc copies, cooperate to control RNA initiation. Sequences located 200bp downstream from the 5' end inhibit expression in a position and orientation-dependent manner. Inhibition appears to be due to reduced translation rather that to impaired synthesis.
The distribution of transposable elements within heterochromatin indicates that they are major structural components of the heterochromatin.
There is no sequence homology between the ends of the Doc element. Different Doc elements are conserved at the 3' end (which terminates with a polyadenylation signal followed by a stretch of oligo-A), but may be truncated at the 5' end, suggesting a mechanism of transposition via an RNA intermediate.
Doc elements lie at both break points of the Antp73b inversion; these elements lie in inverted orientation and the inversion probably resulted from recombination between them.
|Synonyms & Secondary IDs ( 11 )|
(Zhang et al., 2011, ffrench-Constant et al., 2006, Gunawardane et al., 2007, Pane et al., 2011, Lau et al., 2009, Petrov et al., 2011, Mito et al., 2005, Smith et al., 2007, Brennecke et al., 2007, Lecuyer et al., 2007, Kawamura et al., 2008, Ghildiyal et al., 2008, Deloger et al., 2009, Bergman and Bensasson, 2007, Dimitri et al., 2003, Yang and Nuzhdin, 2003, González et al., 2008, Lipatov et al., 2005, Chambeyron et al., 2008, Li et al., 2009, Iklé et al., 2008, Phalke et al., 2009, Fanti et al., 2003, Lu and Clark, 2010, Bergman et al., 2006, Méndez-Lago et al., 2011, Cooper et al., 2010, Handler et al., 2011, Wang and Elgin, 2011, Sienski et al., 2012, Klenov et al., 2011)
|Secondary FlyBase IDs|
|References ( 144 )|
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|Recent research papers ( 12 )|
|Recent reviews (0)|
|All reviews listed in FlyBase were published before 2011|