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General Information
Symbol
Dmel\P{GawB}Dllmd23
Species
D. melanogaster
Name
FlyBase ID
FBti0002783
Also Known As
Dll-GAL4, DllGal4, dllmd23-Gal4, Dll-GAL4md23, Dll-GAL4 (MD23), dll.Gal4, P[Dll-Gal4], Dllmd23, dll, MD23
Description
Inserted Element
Uses

GAL4 reporter/driver

Affected gene(s)
Viability / fertility
Associated allele(s)
Stock availability
LINE ID
Genomic Location
Chromosomal Location
2R ( 60E2 )
Sequence Location
Target / Docking site
Member of Large Scale Dataset(s)
Dataset
Description
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)
60E2 (near gene of known cytology)
Cytological location (reported)
Insertion into Natural transposon
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct
Location-dependent role
Size (Kb)

11.279

Associated alleles
Molecular map
Affected Gene(s)
Insertion may affect gene
(Papadopoulos et al., 2012, Plavicki et al., 2012, Giorgianni and Mann, 2011, Gradilla et al., 2011, Morante et al., 2011, O'Keefe et al., 2011, Ouyang et al., 2011, Pueyo and Couso, 2011, Heffer et al., 2010, Nagai et al., 2010, Papadopoulos et al., 2010, Papadopoulos et al., 2010, Rendina et al., 2010, Umehara et al., 2010, Greenberg and Hatini, 2009, Loya et al., 2009, Terriente-Félix and de Celis, 2009, Brás-Pereira and Casares, 2008, Hamada et al., 2008, Morante and Desplan, 2008, Villányi et al., 2008, Barrio et al., 2007, Félix et al., 2007, Galindo et al., 2007, Garg et al., 2007, Sakurai et al., 2007, Stevens and Mann, 2007, Akasaka et al., 2006, Baena-Lopez and Garcia-Bellido, 2006, Matakatsu and Blair, 2006, Morris et al., 2006, Venkei et al., 2006, Akimoto et al., 2005, Lohr, 2005, Lohr and Pick, 2005, Takaesu et al., 2005, Hamaguchi et al., 2004, Matakatsu and Blair, 2004, Otsuki et al., 2004, Pueyo and Couso, 2004, Sakata, 2004, Yoshida et al., 2004, Astle et al., 2003, Baena-Lopez and Garcia-Bellido, 2003, de Celis Ibeas and Bray, 2003, Emerald et al., 2003, Enerly et al., 2003, Fortier et al., 2003, Hao et al., 2003, Kenyon et al., 2003, Kondoh et al., 2003, Kubota et al., 2003, Roignant et al., 2003, Suzanne et al., 2003, Ward et al., 2003, Azpiazu and Morata, 2002, Dong et al., 2002, Enerly et al., 2002, Galindo et al., 2002, Galindo et al., 2002, Held, 2002, Lee and Adler, 2002, Lockwood and Bodmer, 2002, Nakamura et al., 2002, Reichhart et al., 2002, Shiga et al., 2002, Veraksa et al., 2002, Kammermeier et al., 2001, Lohr et al., 2001, Marquez et al., 2001, Mishra et al., 2001, True et al., 2001, Yoshida et al., 2001, Boube et al., 2000, Boutros et al., 2000, Cavodeassi et al., 2000, Collins and Treisman, 2000, Kubota et al., 2000, Mukherjee et al., 2000, Ruiz-Gomez et al., 2000, Takatsu et al., 2000, Bishop et al., 1999, Gorfinkiel et al., 1999, Moreno and Morata, 1999, Ryoo et al., 1999, True et al., 1999, Weigmann and Cohen, 1999, Casares and Mann, 1998, Halder et al., 1998, Weatherbee et al., 1998, Adler et al., 1997, Gorfinkiel et al., 1997, Lecuit and Cohen, 1997, Calleja, 1996.10.16, Calleja et al., 1996, Gonzalez-Crespo and Morata, 1996)
Alleles and Phenotypes
Allele
Reference(s)
(Caipo et al., 2020, Cho et al., 2020, Lee et al., 2019, Papadopoulos et al., 2019, Enriquez et al., 2018, Kuzin et al., 2018, Morrison et al., 2018, Suzuki et al., 2018, Akishina et al., 2017, Hevia et al., 2017, Requena et al., 2017, Rives-Quinto et al., 2017, Plavicki et al., 2016, Shorter et al., 2016, de Madrid et al., 2015, Guarner et al., 2014, Grubbs et al., 2013, Molnar and de Celis, 2013, Papadopoulos et al., 2012, Plavicki et al., 2012, Giorgianni and Mann, 2011, Gradilla et al., 2011, Kester and Nambu, 2011, Morante et al., 2011, O'Keefe et al., 2011, Ouyang et al., 2011, Pueyo and Couso, 2011, Heffer et al., 2010, Nagai et al., 2010, Papadopoulos et al., 2010, Papadopoulos et al., 2010, Rendina et al., 2010, Tajiri et al., 2010, Umehara et al., 2010, Dey et al., 2009, González and Busturia, 2009, Greenberg and Hatini, 2009, Loya et al., 2009, McKay et al., 2009, Terriente-Félix and de Celis, 2009, Brás-Pereira and Casares, 2008, Hamada et al., 2008, Morante and Desplan, 2008, Villányi et al., 2008, Barrio et al., 2007, Félix et al., 2007, Galindo et al., 2007, Garg et al., 2007, Inoue and Hayashi, 2007, Sakurai et al., 2007, Stevens and Mann, 2007, Akasaka et al., 2006, Baena-Lopez and Garcia-Bellido, 2006, Matakatsu and Blair, 2006, Morris et al., 2006, Venkei et al., 2006, Akimoto et al., 2005, Galindo et al., 2005, Lohr, 2005, Lohr and Pick, 2005, Takaesu et al., 2005, Hamaguchi et al., 2004, Matakatsu and Blair, 2004, Otsuki et al., 2004, Pueyo and Couso, 2004, Sakata, 2004, Yoshida et al., 2004, Astle et al., 2003, Baena-Lopez and Garcia-Bellido, 2003, de Celis Ibeas and Bray, 2003, Emerald et al., 2003, Enerly et al., 2003, Fortier et al., 2003, Hao et al., 2003, Kenyon et al., 2003, Kondoh et al., 2003, Kubota et al., 2003, Roignant et al., 2003, Suzanne et al., 2003, Ward et al., 2003, Azpiazu and Morata, 2002, Dong et al., 2002, Enerly et al., 2002, Galindo et al., 2002, Galindo et al., 2002, Held, 2002, Lee and Adler, 2002, Lockwood and Bodmer, 2002, Nakamura et al., 2002, Reichhart et al., 2002, Shiga et al., 2002, Veraksa et al., 2002, Kammermeier et al., 2001, Lohr et al., 2001, Marquez et al., 2001, Mishra et al., 2001, True et al., 2001, Yoshida et al., 2001, Boube et al., 2000, Boutros et al., 2000, Cavodeassi et al., 2000, Collins and Treisman, 2000, Kubota et al., 2000, Mukherjee et al., 2000, Ruiz-Gomez et al., 2000, Takatsu et al., 2000, Bishop et al., 1999, Gorfinkiel et al., 1999, Moreno and Morata, 1999, Ryoo et al., 1999, True et al., 1999, Weigmann and Cohen, 1999, Casares and Mann, 1998, Halder et al., 1998, Weatherbee et al., 1998, Adler et al., 1997, Gorfinkiel et al., 1997, Lecuit and Cohen, 1997, Calleja, 1996.10.16, Calleja et al., 1996, Gonzalez-Crespo and Morata, 1996)
Expression Data
Reporter Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Drives expression in presumptive distal structures in imaginal discs, including the presumptive tarsal segments of leg discs, the presumptive wing margin, the presumptive second and third segments and arista of the antennal disc, and distal structures of male and female genital discs.

Comparing Scer\GAL4Dll-md23 with anti-Dll staining shows that the Gal4 driver faithfully recapitulates Dll expression with two exceptions: (1) the embryonic ventral nerve cord glia that express Dll lack Scer\GAL4Dll-md23 expression; and (2) several cells in thebrain that express Dll, also lack Scer\GAL4Dll-md23 expression.

Dll reporter is expressed in a small population of neurons located at the most proximal part of the outer optic lobe (neurons generated by the oldest neuroblasts to have emerged from the neuroepithelium) but not in the neuroblasts themselves. Expression persists in pupae.

Scer\GAL4Dll-md23 drives expression in 20% of cells in the medulla cortex and medulla rim. Neurons in the medulla rim have processes in the lamina. Cells labeled with Scer\GAL4Dll-md23 do not overlap with cells expressing Ecol\lacZap-rK568 or Scer\GAL4ey-OK107.

Reporter expression was used to trace the movement of wing primordial cells in the embryo. In embryonic stages 12-14, expressing cell clusters in each thoracic segment extend in the dorsoventral direction. By stage 15, wing and haltere cells are well separated from leg primordia. A dorsal cluster of expressing cells is also observed in the prothoracic segment.

Larval expression is observed in the genital and anal primordia of the male and female genital discs. Adult expression is observed in the vaginal plates in females, in the claspers in males, and in the anal plates of both sexes.

Assayed in adult cuticle using y+ marker. Expressed in distal portions of leg, wing, and antenna; expression in femur relatively weak.

Expression in distal portions of leg and antenna; along dorsal/ventral boundary of wing. Observed as adult y+ phenotype; expression assumed to be earlier.

 
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome
Related Aberration or Balancer
Aberration
Balancer
Stocks (3)
External Crossreferences and Linkouts ( 0 )
Comments
Comments

Isolated using P{UAS-y.C} adult cuticle patterning screen; see FBrf0090484.

Synonyms and Secondary IDs (42)
Reported As
Symbol Synonym
Distal-lesGal4-MD23
Dll-GAL4 (MD23)
Dll-Gal4 (MD23)
Dll-Gal4 (line MD 23)
Dll-Gal4MD23
DllMD23-Gal4
DllGal4MD23
P[GawB]Dll(m23)
P{w+mW.hs = GawB}Dllmd23
P{w+mW.hs=GawB}Dll.MD23
P{w+mW.hs=GawB}Dllmd23
distal-less-GAL4
distalless Gal4
dllmd23-GAL4
Name Synonyms
Secondary FlyBase IDs
  • FBti0002813
References (123)