Dmel\P{GawB}ap^md544 Insertion

General Information
Symbol	Dmel\P{GawB}ap^md544	Species	D. melanogaster
Name		FlyBase ID	FBti0002785
Feature type	transposable_element_insertion_site
Description
Inserted element	P{GawB}	Expression data	GAL4 reporter/driver
Affected gene(s)	ap, Scer\GAL4	Viability / fertility
Causes allele(s)	ap^md544, Scer\GAL4^ap-md544	Stock availability	2 publicly available
LINE ID
Genomic Location
Chromosomal location	2R ( 41F8 )	Sequence location
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Du et al., 2011, PLoS ONE 6(9): e24168 Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226 Hamanaka et al., 2010, Curr. Biol. 20(1): 9--18 Gemmill et al., 2002, Oncogene 21(22): 3507--3516 Wojcinski et al., 2011, Dev. Biol. 358(1): 168--180
FB2012_01	References Franke et al., 2010, Dev. Biol. 345(2): 117--132 Xie et al., 2010, Int. J. Biol. Sci. 6(3): 252--267 Tripura et al., 2011, Int. J. Dev. Biol. 55(6): 583--590 Zamparini et al., 2011, Development 138(18): 4039--4050 Riedel et al., 2011, Development 138(1): 149--158 Deng et al., 2010, Mol. Biol. Cell 21(19): 3304--3316 Xie et al., 2011, Insect Biochem. Mol. Biol. 41(3): 167--177 Hughes et al., 2010, J. Cell Sci. 123(7): 1099--1107 Keleman et al., 2005, Nature Neurosci. 8(2): 156--163 Coleman et al., 2010, Development 137(14): 2417--2426
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	41F8 ( near gene of known cytology )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{GawB}
Location-dependent role	GAL4 driver/enhancer trap (Brand and Perrimon, 1993)
Size	11.279Kb
Associated alleles	Scer\GAL4^wB w^+mW.hs
Molecular map
Affected Gene(s)
Insertion may affect gene	ap (Fradkin et al., 2004, Calleja, 1996.10.16, Bejarano et al., 2008) Scer\GAL4 (Hughes and Fehon, 2006, Yan et al., 2009, Evans et al., 2009, Glise et al., 2005, Li et al., 2006, Stabell et al., 2006, Calleja, 1996.10.16, Bonkowsky et al., 1999, Orihara-Ono et al., 2005, Cha et al., 2005, del Alamo Rodriguez et al., 2002, Dearborn et al., 2002, Milan and Cohen, 1999, Milan and Cohen, 1999, True et al., 1999, Piddini et al., 2005, Nagel et al., 2001, Radimerski et al., 2002, Hewes et al., 2003, Teleman and Cohen, 2006, Montagne et al., 1999, Moreno and Morata, 1999, Keleman and Dickson, 2001, Takeo et al., 2005, Rintelen et al., 2001, Allan et al., 2003, Vanolst et al., 2005, Villa-Cuesta and Modolell, 2005, Weihe et al., 2001, Niwa et al., 2002, Paricio et al., 1999, Yoshida et al., 2001, Herzig et al., 2001, Pena-Rangel et al., 2002, Hidalgo et al., 2001, Greco et al., 2001, van Meyel et al., 2003, Feiguin et al., 2001, Milan et al., 2001, Friedman and Perrimon, 2006, Delanoue et al., 2002, Cavodeassi et al., 2002, Wulbeck and Simpson, 2002, de Navas et al., 2006, Takaesu et al., 2005, Stabell et al., 2006, Milan and Cohen, 2003, Giagtzoglou et al., 2003, Hannus et al., 2002, Ratnaparkhi et al., 2002, Okajima and Irvine, 2002, Speck et al., 2003, Giraldez et al., 2002, Barcelo and Stewart, 2002, Enerly et al., 2002, Hennig and Neufeld, 2002, Garcia-Casado et al., 2002, Price et al., 2002, Giraldez et al., 2002, Azpiazu and Morata, 2002, Callus and Mathey-Prevot, 2002, Matakatsu and Blair, 2004, Milan et al., 2004, Lohr et al., 2002, Nakamura et al., 2002, Fradkin et al., 2004, Copf et al., 2003, Stevaux et al., 2002, Resino and Garcia-Bellido, 2004, Takeo et al., 2004, Fan et al., 2003, Pfeiffer et al., 2002, Weihe et al., 2004, Adachi-Yamada and O'Connor, 2002, Denef et al., 2000, Conley et al., 2000, Park et al., 2004, Calleja et al., 2000, Marques et al., 2003, Campbell and Tomlinson, 2000, Giraldez and Cohen, 2003, Baena-Lopez et al., 2003, Escudero et al., 2003, Horabin et al., 2003, Rincon-Limas et al., 2000, O'Keefe and Thomas, 2001, Nolo et al., 2000, Seher and Leptin, 2000, Tanimoto et al., 2000, Milan and Cohen, 2000, Pueyo et al., 2000, Collins and Treisman, 2000, Culi et al., 2001, Simpson et al., 2000, Rajagopalan et al., 2000, Boutros et al., 2000, Azpiazu and Morata, 2000, Kojima et al., 2000, Lu et al., 1999, Zeitlinger and Bohmann, 1999, van Meyel et al., 1999, Gao et al., 2000, van Meyel et al., 2000, Benveniste et al., 1998, Hepker et al., 1999, Royet et al., 1998, Vervoort et al., 1999, Pickup and Banerjee, 1999, Diez del Corral et al., 1999, Bishop et al., 1999, Rincon-Limas et al., 1999, Ligoxygakis et al., 1999, Ting et al., 2005, Sato et al., 1999, Aldaz et al., 2005, Escudero et al., 2005, Zeng and Verheyen, 2004, Ruiz-Gomez et al., 2000, Methot and Basler, 2000, Lu et al., 2000, Gorfinkiel et al., 1997, Baeg et al., 2004, Pueyo and Couso, 2004, Merdes et al., 2004, Nakano et al., 2004, Perez-Garijo et al., 2004, Miguel-Aliaga et al., 2004, Martin et al., 2004, Kirkpatrick et al., 2004, Marquez et al., 2001, Mihaly et al., 2001, Fernandez-Funez et al., 1998, Mishra et al., 2001, Cho et al., 2001, O'Keefe et al., 1998, Kiger and O'Shea, 2001, Milan et al., 1998, Kango-Singh et al., 2003, Chandra et al., 2003, Chen et al., 2002, Patel et al., 2003, Vegh and Basler, 2003, Allan et al., 2003, Pallavi and Shashidhara, 2003, Milan et al., 1997, Aldaz et al., 2003, Wheeler et al., 2003, Bernard et al., 2003, Villa-Cuesta et al., 2003, Yang et al., 2003, Apidianakis et al., 1999, Kreuger et al., 2004, Gorfinkiel et al., 2005, Horabin, 2005, Matakatsu and Blair, 2006, Bischof et al., 2007, Biryukova and Heitzler, 2005, Cha et al., 2003, Soller et al., 2006, Baena-Lopez and Garcia-Bellido, 2006, Wei et al., 2005, Crickmore and Mann, 2006, Crickmore and Mann, 2006, Oshima, 2006, Blair et al., 2006, Jacobsen et al., 2006, Ramel, 2007, Bischof et al., 2007, Baumgardt et al., 2007, Hyun et al., 2006, Garbe et al., 2007, Hulsmeier et al., 2007, Chung et al., 2007, Secombe et al., 2007, He et al., 2005, He et al., 2005, Stabell et al., 2007, Staudt et al., 2006, Miura et al., 2006, Bardin and Schweisguth, 2006, Wu et al., 2005, Hewes et al., 2006, David et al., 2005, Krieser et al., 2007, Kiger et al., 2007, Park et al., 2008, Markstein et al., 2008, Callejo et al., 2006, Bejarano et al., 2008, Mouchel-Vielh et al., 2008, Yan et al., 2008, Carrera et al., 2008, Gluderer et al., 2008, Schwinkendorf and Gallant, 2009, Moores et al., 2008, Miura et al., 2008, Ueyama et al., 2008, Kim et al., 2007, Zeng et al., 2007, Montero et al., 2008, Jang et al., 2008, Steiger et al., 2008, Hijazi et al., 2009, Yang et al., 2005, Lee et al., 2006, Ayers et al., 2009, Schlichting and Dahmann, 2008, Loewer et al., 2004, Eivers et al., 2009, Zirin and Mann, 2007, Lee et al., 2009, Khaliullina et al., 2009, Morris et al., 2006, Guha et al., 2009, Biryukova and Heitzler, 2008, Bejarano et al., 2007, Johnson et al., 2008, Herranz et al., 2006, Gallet et al., 2008, Bejarano et al., 2010, Yan et al., 2009, Widmann and Dahmann, 2009, Usha and Shashidhara, 2010, Baumgartner et al., 2010, Hermle et al., 2010, Jones et al., 2010, Yang et al., 2009, Cheng et al., 2010, Buechling et al., 2010, Djiane and Mlodzik, 2010, Lee et al., 2010, Yan et al., 2010, Franch-Marro et al., 2008, Jia et al., 2009, Baumgardt et al., 2009, Losada-Pérez et al., 2010, Morton et al., 2008, Rhiner et al., 2010, Lu et al., 2010, Kleinschmit et al., 2010, de Haro et al., 2010, Padash-Barmchi et al., 2010, Zhang et al., 2006, Ellis and Carney, 2011, Kondo and Perrimon, 2011, Furrer et al., 2010, Mesquita et al., 2010, Tortoriello et al., 2010, Bronstein et al., 2010, O'Keefe et al., 2011, Morante et al., 2011, Terriente-Félix et al., 2011, Molnar et al., 2011, Song et al., 2010, Resnik-Docampo and de Celis, 2011, Kawamori and Yamaguchi, 2011, Fernández et al., 2011, Hijazi et al., 2011, Montagne et al., 2010, Loncle et al., 2007, Liu et al., 2011, Wojcinski et al., 2011, Du et al., 2011, Gemmill et al., 2002, Hamanaka et al., 2010, Jia et al., 2010, Riedel et al., 2011, Tripura et al., 2011, Franke et al., 2010, Hughes et al., 2010, Keleman et al., 2005, Coleman et al., 2010, Xie et al., 2011, Xie et al., 2010, Deng et al., 2010, Zamparini et al., 2011)
Alleles and Phenotypes
Causes alleles	ap^md544 (Calleja, 1996.10.16, Milan and Cohen, 1999, Milan et al., 2001, Milan and Cohen, 2003, Rincon-Limas et al., 2000, O'Keefe and Thomas, 2001, van Meyel et al., 1999, van Meyel et al., 2000, Benveniste et al., 1998, Rincon-Limas et al., 1999, Pueyo and Couso, 2004, O'Keefe et al., 1998, Bejarano et al., 2008) Scer\GAL4^ap-md544 (Calleja, 1996.10.16, Hughes and Fehon, 2006, Bonkowsky et al., 1999, Yan et al., 2009, Orihara-Ono et al., 2005, Cha et al., 2005, del Alamo Rodriguez et al., 2002, Dearborn et al., 2002, Milan and Cohen, 1999, Milan and Cohen, 1999, True et al., 1999, Piddini et al., 2005, Nagel et al., 2001, Radimerski et al., 2002, Hewes et al., 2003, Teleman and Cohen, 2006, Montagne et al., 1999, Moreno and Morata, 1999, Keleman and Dickson, 2001, Takeo et al., 2005, Rintelen et al., 2001, Allan et al., 2003, Vanolst et al., 2005, Villa-Cuesta and Modolell, 2005, Weihe et al., 2001, Niwa et al., 2002, Paricio et al., 1999, Yoshida et al., 2001, Herzig et al., 2001, Pena-Rangel et al., 2002, Hidalgo et al., 2001, Greco et al., 2001, van Meyel et al., 2003, Feiguin et al., 2001, Milan et al., 2001, Friedman and Perrimon, 2006, Delanoue et al., 2002, Evans et al., 2009, Cavodeassi et al., 2002, Wulbeck and Simpson, 2002, de Navas et al., 2006, Takaesu et al., 2005, Stabell et al., 2006, Milan and Cohen, 2003, Giagtzoglou et al., 2003, Hannus et al., 2002, Ratnaparkhi et al., 2002, Okajima and Irvine, 2002, Speck et al., 2003, Giraldez et al., 2002, Barcelo and Stewart, 2002, Enerly et al., 2002, Hennig and Neufeld, 2002, Garcia-Casado et al., 2002, Price et al., 2002, Giraldez et al., 2002, Azpiazu and Morata, 2002, Callus and Mathey-Prevot, 2002, Matakatsu and Blair, 2004, Milan et al., 2004, Lohr et al., 2002, Nakamura et al., 2002, Fradkin et al., 2004, Copf et al., 2003, Stevaux et al., 2002, Resino and Garcia-Bellido, 2004, Takeo et al., 2004, Fan et al., 2003, Pfeiffer et al., 2002, Weihe et al., 2004, Adachi-Yamada and O'Connor, 2002, Denef et al., 2000, Conley et al., 2000, Park et al., 2004, Calleja et al., 2000, Marques et al., 2003, Campbell and Tomlinson, 2000, Giraldez and Cohen, 2003, Baena-Lopez et al., 2003, Escudero et al., 2003, Horabin et al., 2003, Rincon-Limas et al., 2000, O'Keefe and Thomas, 2001, Nolo et al., 2000, Seher and Leptin, 2000, Tanimoto et al., 2000, Milan and Cohen, 2000, Glise et al., 2005, Pueyo et al., 2000, Collins and Treisman, 2000, Culi et al., 2001, Simpson et al., 2000, Rajagopalan et al., 2000, Boutros et al., 2000, Azpiazu and Morata, 2000, Kojima et al., 2000, Lu et al., 1999, Zeitlinger and Bohmann, 1999, van Meyel et al., 1999, Gao et al., 2000, van Meyel et al., 2000, Benveniste et al., 1998, Hepker et al., 1999, Royet et al., 1998, Vervoort et al., 1999, Pickup and Banerjee, 1999, Diez del Corral et al., 1999, Bishop et al., 1999, Rincon-Limas et al., 1999, Ligoxygakis et al., 1999, Ting et al., 2005, Sato et al., 1999, Aldaz et al., 2005, Escudero et al., 2005, Zeng and Verheyen, 2004, Ruiz-Gomez et al., 2000, Methot and Basler, 2000, Lu et al., 2000, Gorfinkiel et al., 1997, Baeg et al., 2004, Pueyo and Couso, 2004, Merdes et al., 2004, Nakano et al., 2004, Perez-Garijo et al., 2004, Miguel-Aliaga et al., 2004, Martin et al., 2004, Kirkpatrick et al., 2004, Marquez et al., 2001, Mihaly et al., 2001, Fernandez-Funez et al., 1998, Mishra et al., 2001, Cho et al., 2001, O'Keefe et al., 1998, Kiger and O'Shea, 2001, Milan et al., 1998, Kango-Singh et al., 2003, Chandra et al., 2003, Chen et al., 2002, Patel et al., 2003, Vegh and Basler, 2003, Allan et al., 2003, Pallavi and Shashidhara, 2003, Milan et al., 1997, Aldaz et al., 2003, Wheeler et al., 2003, Bernard et al., 2003, Villa-Cuesta et al., 2003, Yang et al., 2003, Apidianakis et al., 1999, Kreuger et al., 2004, Gorfinkiel et al., 2005, Horabin, 2005, Matakatsu and Blair, 2006, Bischof et al., 2007, Biryukova and Heitzler, 2005, Cha et al., 2003, Soller et al., 2006, Baena-Lopez and Garcia-Bellido, 2006, Wei et al., 2005, Crickmore and Mann, 2006, Crickmore and Mann, 2006, Oshima, 2006, Blair et al., 2006, Jacobsen et al., 2006, Ramel, 2007, Stabell et al., 2006, Li et al., 2006, Bischof et al., 2007, Baumgardt et al., 2007, Hyun et al., 2006, Garbe et al., 2007, Hulsmeier et al., 2007, Chung et al., 2007, Secombe et al., 2007, He et al., 2005, He et al., 2005, Stabell et al., 2007, Staudt et al., 2006, Miura et al., 2006, Bardin and Schweisguth, 2006, Wu et al., 2005, Hewes et al., 2006, David et al., 2005, Krieser et al., 2007, Kiger et al., 2007, Park et al., 2008, Markstein et al., 2008, Callejo et al., 2006, Bejarano et al., 2008, Mouchel-Vielh et al., 2008, Yan et al., 2008, Carrera et al., 2008, Gluderer et al., 2008, Schwinkendorf and Gallant, 2009, Moores et al., 2008, Miura et al., 2008, Ueyama et al., 2008, Kim et al., 2007, Zeng et al., 2007, Montero et al., 2008, Jang et al., 2008, Steiger et al., 2008, Hijazi et al., 2009, Yang et al., 2005, Lee et al., 2006, Ayers et al., 2009, Schlichting and Dahmann, 2008, Loewer et al., 2004, Eivers et al., 2009, Zirin and Mann, 2007, Lee et al., 2009, Khaliullina et al., 2009, Morris et al., 2006, Guha et al., 2009, Biryukova and Heitzler, 2008, Bejarano et al., 2007, Johnson et al., 2008, Herranz et al., 2006, Gallet et al., 2008, Bejarano et al., 2010, Yan et al., 2009, Widmann and Dahmann, 2009, Usha and Shashidhara, 2010, Baumgartner et al., 2010, Hermle et al., 2010, Jones et al., 2010, Yang et al., 2009, Cheng et al., 2010, Buechling et al., 2010, Djiane and Mlodzik, 2010, Lee et al., 2010, Yan et al., 2010, Franch-Marro et al., 2008, Jia et al., 2009, Baumgardt et al., 2009, Losada-Pérez et al., 2010, Morton et al., 2008, Rhiner et al., 2010, Lu et al., 2010, Kleinschmit et al., 2010, de Haro et al., 2010, Padash-Barmchi et al., 2010, Zhang et al., 2006, Ellis and Carney, 2011, Kondo and Perrimon, 2011, Furrer et al., 2010, Mesquita et al., 2010, Tortoriello et al., 2010, Bronstein et al., 2010, O'Keefe et al., 2011, Morante et al., 2011, Terriente-Félix et al., 2011, Molnar et al., 2011, Song et al., 2010, Resnik-Docampo and de Celis, 2011, Kawamori and Yamaguchi, 2011, Fernández et al., 2011, Hijazi et al., 2011, Montagne et al., 2010, Loncle et al., 2007, Liu et al., 2011, Wojcinski et al., 2011, Du et al., 2011, Gemmill et al., 2002, Hamanaka et al., 2010, Jia et al., 2010, Riedel et al., 2011, Tripura et al., 2011, Franke et al., 2010, Hughes et al., 2010, Keleman et al., 2005, Coleman et al., 2010, Xie et al., 2011, Xie et al., 2010, Deng et al., 2010, Zamparini et al., 2011)

Lethality References lethal (Rincon-Limas et al., 2000, Delanoue et al., 2002)
Sterility References sterile (Rincon-Limas et al., 1999, Rincon-Limas et al., 2000) sterile \| recessive (O'Keefe et al., 1998)
Phenotype Manifest In
	embryonic/larval neuron (van Meyel et al., 2000) embryonic deuterocerebrum (Herzig et al., 2001) embryonic protocerebrum (Herzig et al., 2001) haltere (Rincon-Limas et al., 1999) interneuron \| embryonic stage (Herzig et al., 2001, van Meyel et al., 2000) longitudinal connective (O'Keefe et al., 1998, van Meyel et al., 2000) ovary (Rincon-Limas et al., 2000) presumptive embryonic/larval central nervous system (O'Keefe et al., 1998) pretarsus (Pueyo and Couso, 2004, Pueyo et al., 2000) scutellum (Rincon-Limas et al., 1999) tarsal segment 4 (Pueyo and Couso, 2004, Pueyo et al., 2000) wing (van Meyel et al., 1999, Milan and Cohen, 1999, O'Keefe et al., 1998, Rincon-Limas et al., 2000, Milan et al., 2001, Milan and Cohen, 1999, Rincon-Limas et al., 1999, Weihe et al., 2001, O'Keefe and Thomas, 2001) wing \| heat sensitive (O'Keefe and Thomas, 2001) wing disc (Milan and Cohen, 1999, Milan and Cohen, 2003) wing disc \| dorsal/ventral compartment boundary (Milan et al., 2001, O'Keefe and Thomas, 2001) wing margin (Rincon-Limas et al., 2000, O'Keefe et al., 1998, Milan et al., 2001, O'Keefe and Thomas, 2001) wing margin bristle (Milan and Cohen, 1999)
Detailed Description
Statement Reference Flies expressing fng[Scer\UAS.cKa] under the control of Scer\GAL4[ap-md544] in a ap[rK568]/ap[md544] background have ventralised halteres. In addition, the halteres form dark-pigmented bristles that are similar to those formed at the wing margin. (Tomoyasu et al., 2009) Bx[1]/Y ; ap[md544]/+ males have a strong wing scalloping phenotype. (Bejarano et al., 2008) ap^md544/+ enhances the severity of the Bx¹ wing scalloping phenotype. (Milan et al., 2004) ap^md544/+ does not cause any visible leg phenotypes in combination with Chi^g371/+, Chi^g96.1/+ or Chi^e5.5/+. ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^ap-md544 suppresses fusion of tarsal segments 4 and 5 in ap^UGO35/ap^md544 flies. ap::Lim3^Scer\UAS.cOa; Scer\GAL4^ap-md544 suppresses fusion of tarsal segments 4 and 5 in ap^UGO35/ap^md544 flies. (Pueyo and Couso, 2004) In ap^UGO35/ap^md544 and in ap^md544/Df(2R)nap1 flies, the fourth tarsal segment is almost completely lost. The remnant is fused to the fifth tarsal segment. Other segments are normal. (Pueyo and Couso, 2004) Reduction and fusion of the fourth tarsal segment in ap^md544/Df(2R)nap1 animals is rescued by ap^Scer\UAS.cOa. (Pueyo and Couso, 2004) Mutant animals show a weak phenotype in the wing disc, the dorsal ventral affinity boundary is disrupted. The phenotype is stronger in ap^rK568/ap^md544 animals and stronger still with ap^UGO35/ap^md544. (Milan and Cohen, 2003) Neurons which normally express ap (Ap neurons) are still present and extend axons in ap^P44/ap^md544 embryonic brains. However, Ap brain interneurons show defasciculation and pathfinding defects in these animals. The most severe defects are seen in the deutocerebrum, where the two pairs of Ap neuronal cell bodies are positioned incorrectly. These neurons do not appear to undergo the movements seen in wild-type embryos and never become localised on the inner surface of the developing deutocerebrum, instead remaining on the outer surface, with their axons projecting aberrantly along the frontal commissure of the stomatogastric nervous system or in rare cases along the recurrent nerve. The cell bodies of the Ap neurons in the protocerebrum appear to be positioned properly and have a normal size and shape, but many of their commissural axons fail to form commissural fascicles correctly and often leave their commissural bundle and cross over to grow along a neighbouring fascicle. This defect is seen in 30% of cases. Ap neurons that innervate the ring gland have normal axonal projection patterns. Fas2-expressing commissural fascicles are indistinguishable from wild type. (Herzig et al., 2001) Expression of Dr^Scer\UAS.cIa under the control of Scer\GAL4^ap-md544 in ap^md544/ap^UGO35 flies does not restore outgrowth of the wing, although the few margin bristles seen in the dorsal surface of these wings have dorsal identity. Growth of the wing and wing margin formation can be restored in ap^md544/ap^UGO35 flies expressing fng^EP3082 under the control of Scer\GAL4^ap-md544. Both surfaces of the wing differentiate ventral structures; the anterior wing margin and alula differentiate ventral bristles on both surfaces and the pattern of vein corrugation is ventral. Co-expression of fng^EP3082 and Dr^Scer\UAS.cIa under the control of Scer\GAL4^ap-md544 in ap^md544/ap^UGO35 flies results in dorsal differentiation in bristles of the dorsal anterior wing margin. (Milan et al., 2001) Expression of caps^Scer\UAS.cSa under the control of Scer\GAL4^ap-md544 restores the smooth interface between dorsal and ventral cells in ap^md544/ap^UGO35 wing discs. The boundary between the dorsal and ventral cells is still irregular in ap^md544/ap^UGO35 wing discs expressing trn^Scer\UAS.cMa under the control of Scer\GAL4^ap-md544. Expression of Con^Scer\UAS.cRa or fng^EP3082 under the control of Scer\GAL4^ap-md544 does not restore a smooth boundary between the dorsal and ventral cells in ap^md544/ap^UGO35 wing discs. (Milan et al., 2001) The wing margin is reduced and the wing is considerably smaller than normal in ap^md544/ap^UGO35 flies. When present, wing margin bristles have ventral identity. (Milan et al., 2001) ap^md544/ap^UGO35 wing discs do not form a smooth boundary between dorsal and ventral cells. (Milan et al., 2001) A sharp boundary between dorsal and ventral cells is restored in ap^rK568/ap^md544 wing discs expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544. No violations of the compartment boundary are seen. The resulting adult flies have wings of roughly normal size with clearly demarcated wing margin. The rescued wing margin is ventralised; dorsal-specific sensory bristles are completely missing along the anterior margin and cells on both sides of the margin secrete ventral bristle types. The dorsal and ventral wing surfaces are not adhered to each other, resulting in a balloon-like structure. ap^UGO35/ap^md544 flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 do not have wing margin defects. Coexpression of mew^Scer\UAS.cWa and fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 partially rescues the ap^ts78j/ap^md544 wing phenotype; the overall size and shape, apposition of the two surfaces, position of the wing margin and pattern of the wing veins are remarkably normal. However, these wings consist entirely of ventral cell types. Firstly, the rescued wing margins lack the dorsal-specific bristles types and instead have ventral bristle types on both surfaces. Secondly, the wings have many more alula bristles than normal (which in wild-type are derived only from the ventral surface). Thirdly, a mechanosensory campaniform sensillum that is normally located only on the ventral surface of vein L3 is duplicated and present on both surfaces of the rescued wing. Finally, the morphology of the wing veins indicate that they entirely of ventral identity (the veins show a ventral corrugation pattern on both surfaces of the wing). (O'Keefe and Thomas, 2001) The D/V compartment boundary of ap^rK568/ap^md544 wing discs is highly irregular (in contrast to wild type). The resulting adult wings are almost completely eliminated and show no evidence of a wing margin. ap^ts78j/ap^md544 flies show a nearly complete loss of wings at 25^oC. (O'Keefe and Thomas, 2001) A sharp boundary between dorsal and ventral cells is restored in ap^rK568/ap^md544 wing discs expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544. No violations of the compartment boundary are seen. The resulting adult flies have wings of roughly normal size with clearly demarcated wing margin. The rescued wing margin is ventralised; dorsal-specific sensory bristles are completely missing along the anterior margin and cells on both sides of the margin secrete ventral bristle types. The dorsal and ventral wing surfaces are not adhered to each other, resulting in a balloon-like structure. ap^UGO35/ap^md544 flies expressing fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 do not have wing margin defects. Coexpression of mew^Scer\UAS.cWa and fng^Scer\UAS.cKa under the control of Scer\GAL4^ap-md544 partially rescues the ap^ts78j/ap^md544 wing phenotype; the overall size and shape, apposition of the two surfaces, position of the wing margin and pattern of the wing veins are remarkably normal. However, these wings consist entirely of ventral cell types. Firstly, the rescued wing margins lack the dorsal-specific bristles types and instead have ventral bristle types on both surfaces. Secondly, the wings have many more alula bristles than normal (which in wild-type are derived only from the ventral surface). Thirdly, a mechanosensory campaniform sensillum that is normally located only on the ventral surface of vein L3 is duplicated and present on both surfaces of the rescued wing. Finally, the morphology of the wing veins indicate that they are entirely of ventral identity (the veins show a ventral corrugation pattern on both surfaces of the wing). (O'Keefe and Thomas, 2001) ap^md544/ap^UGO35 fail to develop normal wings. (Weihe et al., 2001) Transheterozygotes with Df(2R)nap1 show fusion of tarsus 4 with 5, reduction and deformity or loss of tarsus 4. Tarsus four and five fusions appear with lower frequency and expressivity in ap^UGO35/ap^md544 transheterozygotes. (Pueyo et al., 2000) ap^md544/ap^UGO35 flies have immature ovaries, are sterile, die within 24-72 hours of eclosion and have no wings. ap^md544/ap^ts78j flies grown at 25^oC have wings that lack most of the wing margin but have good proximo-distal growth. ap^md544/ap^ts78j flies grown at 25^oC have wings that lack most of the wing margin but have good proximo-distal growth. The addition of ap^{HA-B.Scer\UAS} severely reduces proximo-distal growth and wing size. (Rincon-Limas et al., 2000) In ap^md544/ap^P44 embryos, all neurons that normally express ap survive and extend axons, but these axons display pathfinding errors in nearly every segment, including defasciculation of axon bundles, aberrant pathway selection within the longitudinal connectives, occasional misrouting across the midline and stalling. (van Meyel et al., 2000) No increase in axon guidance defects is seen in ap^md544/Chi^e5.5 transheterozygotes compared to ap^md544/+ or Chi^e5.5/+ embryos. ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC} rescues pathway recognition and axon fasciculation in a majority of segments in ap^md544/ap^P44 embryos when expressed under the control of Scer\GAL4^ap-md544. The axon guidance defects seen in ap^md544/ap^P44 embryos are not rescued by coexpression of ap^{ΔLIM.Scer\UAS} and Chi^{ΔLID.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ap-md544. The axon defects seen in Chi^e5.5 ap^md544/ap^P44 double mutants are completely rescued by ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC} expressed under the control of Scer\GAL4^ap-md544. (van Meyel et al., 2000) ap^md544/ap^P44 flies show wing defects. This phenotype is suppressed by expression of ap^Scer\UAS.cMa or ap::Chi^{ChAp.Scer\UAS} under the control of Scer\GAL4^ap-md544. (Milan and Cohen, 1999) ap^md544/ap^UGO35 flies show reduction of the wing and complete loss of wing margin. ap^md544/ap^UGO35 wing discs have small wing pouches. (Milan and Cohen, 1999) Expression of Ser^Scer\UAS.cSa under the control of Scer\GAL4^ap-md544 in ap^md544/ap^UGO35 flies restores the wing margin and supports growth of the wing. Patches of ectopic wing margin are found in both surfaces of the rescued wings and overgrowth of the wing can be seen. Expression of fng^EP3082 under the control of Scer\GAL4^ap-md544 rescues the phenotype of ap^md544/ap^UGO35 flies. Patches of ectopic wing margin form and can be associated with outgrowth of the wing. Groups of cells appear to violate the dorsoventral boundary in ap^md544/ap^UGO35 wing discs which are also expressing Ser^Scer\UAS.cSa under the control of Scer\GAL4^ap-md544. The mispositioned patches of dorsal or ventral cells form relatively smooth interfaces with surrounding cells. Cells appear to violate the dorsoventral boundary in ap^md544/ap^UGO35 wing discs which are also expressing fng^EP3082 under the control of Scer\GAL4^ap-md544. Expression of both Ser^Scer\UAS.cSa and fng^EP3082 under the control of Scer\GAL4^ap-md544 in ap^md544/ap^UGO35 flies results in well-developed wings which differentiate ventral features on both surfaces; the wing margin, veins and sense organs on the topologically dorsal surface have exclusively ventral identity. (Milan and Cohen, 1999) ap^md544/ap^UGO35 flies lack wings, halteres and the scutellum region of the notum. The flies are sterile and have a lifespan of 1-3 days after eclosion. (Rincon-Limas et al., 1999) ap^md544/ap^UGO35 flies rescued by the expression of Hsap\LHX2^Scer\UAS.cRa under the control of Scer\GAL4^ap-md544 often develop one to two extra bristles in the scutellum. The phenotypes of ap^md544/ap^UGO35 flies are rescued by Hsap\LHX2^Scer\UAS.cRa expressed under the control of Scer\GAL4^ap-md544. ap^md544/ap^UGO35 flies rescued by the expression of Hsap\LHX2^Scer\UAS.cRa under the control of Scer\GAL4^ap-md544 often develop one to two extra bristles in the scutellum. (Rincon-Limas et al., 1999) Heterozygotes have no wing defects. ap^md544/ap^P44 flies have no wings but often have a ribbon- or nub-like outgrowth that lacks any recognisable structures. (van Meyel et al., 1999) ap^P44/ap^md544 embryos show proper positioning of the thoracic ventrolateral clusters in the central nervous system and their axonal bundles appear normal. (Benveniste et al., 1998) Lim3^Scer\UAS.cOa expressed under the control of Scer\GAL4^ap-md544 partially rescues both the wing and embryonic central nervous system phenotype of ap^md544/ap^P44 animals at 18^oC and 25^oC respectively. The wing, sterility and uncoordinated behaviour phenotypes of ap^md544/ap^P44 flies are rescued by ap::Lim3^Scer\UAS.cOa expressed under the control of Scer\GAL4^ap-md544 to the same extent as the rescue seen by ap^Scer\UAS.cOa. In contrast, the axon pathfinding phenotype of ap^md544/ap^P44 embryos is only partially rescued by ap::Lim3^Scer\UAS.cOa expressed under the control of Scer\GAL4^ap-md544. (O'Keefe et al., 1998) ap^md544/ap^P44 flies have no wings, although they often have a ribbon-like outgrowth in the wing region that lacks any recognisable structures. Homozygous adults are sterile, uncoordinated and have a reduced lifespan. Axon pathfinding errors are seen in the central nervous system of ap^md544/ap^P44 embryos; neurons that normally express ap wander within the longitudinal connective and fail to fasciculate with one another. ap^md544/ap^ts78j flies have defective wing margins and unfused wing surfaces at 18^oC. Introduction of ap^{ΔHD.Scer\UAS} into this background (expressed under the control of Scer\GAL4^ap-md544) eliminates the wing blade altogether. (O'Keefe et al., 1998) A single copy of ap^Scer\UAS.cOa expressed under the control of Scer\GAL4^ap-md544 almost completely rescues the wing phenotype of ap^md544/ap^P44 flies; the wing blade is normal in size, with a normal margin and vein pattern, but is held at right angles away from the body. The sterility and uncoordinated behaviour phenotypes of ap^md544/ap^P44 flies are also rescued and the central nervous system defects of embryos are rescued. The adult and embryonic phenotypes of ap^md544/ap^P44 animals are not rescued by ap^{ΔLIM.Scer\UAS} expressed under the control of Scer\GAL4^ap-md544. The ribbon-like outgrowth seen in ap^md544/ap^P44 flies is entirely eliminated in flies expressing ap^{ΔHD.Scer\UAS} under the control of Scer\GAL4^ap-md544. (O'Keefe et al., 1998)
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS) Stage Tissue/Position (including subcellular localization) Reference embryonic stage medial longitudinal fascicle (Fradkin et al., 2004) ventral nerve cord \| restricted (Benveniste et al., 1998) embryonic stage 10 -- 17 organism \| restricted (Marquez et al., 2001) larval stage haltere disc (Moreno and Morata, 1999) ventral thoracic disc \| restricted (Azpiazu and Morata, 2002) wing disc (Moreno and Morata, 1999) Tv neuron (Baumgardt et al., 2007) Tvb neuron (Baumgardt et al., 2007) first instar larval stage neuron \| subset of larval thoracic segment (Benveniste et al., 1998) neuron \| subset of embryonic/larval subesophageal ganglion (Benveniste et al., 1998) Tv neuron \| subset (Benveniste et al., 1998) third instar larval stage wing disc \| restricted (Milan et al., 1997)
Additional Information
Statement Reference

Marker for	dorsal mesothoracic disc (Moreno and Morata, 1999) dorsal mesothoracic disc dorsal metathoracic disc (Moreno and Morata, 1999) dorsal metathoracic disc (Moreno and Morata, 1999) medial longitudinal fascicle (Fradkin et al., 2004) ventral thoracic disc \| restricted (Azpiazu and Morata, 2002)
Reflects expression of	ap (Calleja, 1996.10.16, Milan et al., 1997, Moreno and Morata, 1999, Fradkin et al., 2004, Azpiazu and Morata, 2002)
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 2 )
Bloomington	3041 y¹ w¹¹¹⁸; P{GawB}ap^md544/CyO
Kyoto	106798 y¹ w¹¹¹⁸; P{GawB}ap^md544/CyO
Linkouts
Comments
	Isolated using P{UAS-y.C} adult cuticle patterning screen; see FBrf0090484. (Calleja, 1996.10.16)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	(ap)-GAL4 (Takeo et al., 2005, Cho et al., 2001) (ap)-gal4 (Matakatsu and Blair, 2006) ap (Jang et al., 2008, Morris et al., 2006) ap::Gal4 (Hulsmeier et al., 2007, Markstein et al., 2008, Mouchel-Vielh et al., 2008) ap.Gal4 (Marquez et al., 2001, Takaesu et al., 2005) ap^gal4 (Milan et al., 2004) ap^Gal4 (Delanoue et al., 2002, Baumgardt et al., 2009) ap^MD544 (Biryukova and Heitzler, 2008) ap^md544 (Losada-Pérez et al., 2010) ap^md544-Gal4 (Nagel et al., 2001, Ellis and Carney, 2011, Morante et al., 2011) ap^md544-GAL4 (Apidianakis et al., 1999) ap^γαλ4 (Weihe et al., 2004) ap>Gal4 (Marques et al., 2003) ap-G4 (Du et al., 2011) apG4^md544 (Baena-Lopez and Garcia-Bellido, 2006) ap-Gal (Zirin and Mann, 2007, Lee et al., 2009) ap-GAL4 (Cha et al., 2005, Villa-Cuesta and Modolell, 2005, Merdes et al., 2004, Nakano et al., 2004, Pallavi and Shashidhara, 2003, Bernard et al., 2003, Allan et al., 2003, van Meyel et al., 2003, Chandra et al., 2003, Kango-Singh et al., 2003, Barcelo and Stewart, 2002, Stevaux et al., 2002, Adachi-Yamada and O'Connor, 2002, del Alamo Rodriguez et al., 2002, Pfeiffer et al., 2002, Radimerski et al., 2002, Niwa et al., 2002, Yoshida et al., 2001, Mishra et al., 2001, Mihaly et al., 2001, Methot and Basler, 2000, Rajagopalan et al., 2000, Conley et al., 2000, Paricio et al., 1999, Diez del Corral et al., 1999, Ligoxygakis et al., 1999, Pickup and Banerjee, 1999, Royet et al., 1998, Ueyama et al., 2008, Montagne et al., 1999, Kojima et al., 2000, Fradkin et al., 2004, Milan et al., 1997, Gorfinkiel et al., 2005, Horabin, 2005, Cha et al., 2003, Jacobsen et al., 2006, Ramel, 2007, Stabell et al., 2006, Riedel et al., 2011, Tripura et al., 2011, Furrer et al., 2010, Stabell et al., 2006, Hamanaka et al., 2010, He et al., 2005, He et al., 2005, Carrera et al., 2008, Schwinkendorf and Gallant, 2009, Miura et al., 2008, Kim et al., 2007, Steiger et al., 2008, Evans et al., 2009, Yan et al., 2009, Schlichting and Dahmann, 2008, Khaliullina et al., 2009, Widmann and Dahmann, 2009, Usha and Shashidhara, 2010, Cheng et al., 2010, Lee et al., 2010, de Haro et al., 2010, Kondo and Perrimon, 2011, Tortoriello et al., 2010, Liu et al., 2011) ap-Gal4 (Orihara-Ono et al., 2005, Aldaz et al., 2005, Escudero et al., 2005, Baeg et al., 2004, Perez-Garijo et al., 2004, Martin et al., 2004, Zeng and Verheyen, 2004, Escudero et al., 2003, Aldaz et al., 2003, Villa-Cuesta et al., 2003, Hewes et al., 2003, Giagtzoglou et al., 2003, Okajima and Irvine, 2002, Azpiazu and Morata, 2002, Nakamura et al., 2002, Lohr et al., 2002, Cavodeassi et al., 2002, Price et al., 2002, Rintelen et al., 2001, Culi et al., 2001, Calleja et al., 2000, Campbell and Tomlinson, 2000, Azpiazu and Morata, 2000, Tanimoto et al., 2000, Zeitlinger and Bohmann, 1999, Moreno and Morata, 1999, Vervoort et al., 1999, Bishop et al., 1999, Sato et al., 1999, Montero et al., 2008, Kreuger et al., 2004, Bischof et al., 2007, Biryukova and Heitzler, 2005, Wei et al., 2005, Crickmore and Mann, 2006, Crickmore and Mann, 2006, de Navas et al., 2006, Chung et al., 2007, Zhang et al., 2006, Bischof et al., 2007, Molnar et al., 2011, O'Keefe et al., 2011, Du et al., 2011, Bardin and Schweisguth, 2006, Hewes et al., 2006, Stabell et al., 2007, Fernández et al., 2011, Callejo et al., 2006, Yan et al., 2008, Gluderer et al., 2008, Moores et al., 2008, Yang et al., 2005, Lee et al., 2006, Loewer et al., 2004, Zirin and Mann, 2007, Guha et al., 2009, Biryukova and Heitzler, 2008, Bejarano et al., 2007, Herranz et al., 2006, Gallet et al., 2008, Bejarano et al., 2010, Yan et al., 2009, Baumgartner et al., 2010, Jones et al., 2010, Djiane and Mlodzik, 2010, Yan et al., 2010, Franch-Marro et al., 2008, Jia et al., 2009, Losada-Pérez et al., 2010, Lu et al., 2010, Kleinschmit et al., 2010, Bronstein et al., 2010, Terriente-Félix et al., 2011, Resnik-Docampo and de Celis, 2011, Montagne et al., 2010, Loncle et al., 2007, Jia et al., 2010, Xie et al., 2011, Xie et al., 2010) apGal4 (Pueyo and Couso, 2004, Resino and Garcia-Bellido, 2004, Pueyo et al., 2000, Boutros et al., 2000, Friedman and Perrimon, 2006, Ayers et al., 2009, Buechling et al., 2010, Song et al., 2010, Coleman et al., 2010) ap-gal4 (Matakatsu and Blair, 2004, Weihe et al., 2004, Baena-Lopez et al., 2003, Giraldez and Cohen, 2003, Park et al., 2008) Ap-GAL4 (Fradkin et al., 2004, Ratnaparkhi et al., 2002, Keleman and Dickson, 2001, Simpson et al., 2000, Ruiz-Gomez et al., 2000, Hermle et al., 2010, Morton et al., 2008, Liu et al., 2011, Keleman et al., 2005) ApGal4 (Fan et al., 2003) apGAL4 (Patel et al., 2003, Pena-Rangel et al., 2002, Feiguin et al., 2001, Rincon-Limas et al., 2000, Hepker et al., 1999, Fernandez-Funez et al., 1998, Soller et al., 2006, Hughes and Fehon, 2006, Staudt et al., 2006, Hijazi et al., 2009) ApGAL4 (Hannus et al., 2002) Apgal4 (Greco et al., 2001) ap-GAl4 (Li et al., 2006) Ap-Gal4 (Rhiner et al., 2010, Deng et al., 2010) ap Gal4 (Hughes et al., 2010) ap-GAL4^md544 (Lu et al., 2000) apGAL4^MD544 (Rincon-Limas et al., 2000) ap-Gal4^md544 (Oshima, 2006) apterous (ap)-GAL4 (Miura et al., 2006) apterous^GAL4 (Denef et al., 2000) apterous-G4 (Baena-Lopez and Garcia-Bellido, 2006) Apterous-Gal4 (Teleman and Cohen, 2006, Ting et al., 2005, Eivers et al., 2009) apterous-GAL4 (Copf et al., 2003, Takeo et al., 2004, Yang et al., 2003, Hennig and Neufeld, 2002, Kiger and O'Shea, 2001, Nolo et al., 2000, Seher and Leptin, 2000, Gao et al., 2000, Wu et al., 2005, Krieser et al., 2007, Franke et al., 2010, Johnson et al., 2008, Padash-Barmchi et al., 2010, Gemmill et al., 2002) apterousGAL4 (Horabin et al., 2003, Hidalgo et al., 2001) apterous-Gal4 (Wheeler et al., 2003, Speck et al., 2003, Garcia-Casado et al., 2002, Lu et al., 1999, Secombe et al., 2007, David et al., 2005, Kiger et al., 2007, Yan et al., 2008, Zeng et al., 2007, Eivers et al., 2009, Zirin and Mann, 2007, Rhiner et al., 2010, Kleinschmit et al., 2010, Song et al., 2010, Wojcinski et al., 2011, Zamparini et al., 2011) Apterous GAL4 (Hannus et al., 2002) apterous Gal4 (Hyun et al., 2006) Apterous Gal4 (Eivers et al., 2009) apt-gal4 (Vegh and Basler, 2003) AptGal4 (Garbe et al., 2007) aptGal4 (Yang et al., 2009) Gal4-ap (Wulbeck and Simpson, 2002) GAL4-apterous (Montagne et al., 1999) GAL-ap⁺ (Enerly et al., 2002) md544 (Callus and Mathey-Prevot, 2002) md554 (Kojima et al., 2000) P(GawB)ap^md544 (Hijazi et al., 2011) P[GawB]ap^md544 (Blair et al., 2006) P{GawB}ap^md544 (FlyBase, 1992-, Kiger et al., 2007, Evans et al., 2009, Kawamori and Yamaguchi, 2011) P{w^+mW.hs=GawB}ap^md544 (FlyBase, 1992-, Markstein et al., 2008)
Secondary FlyBase IDs
	FBti0002814
References ( 280 )

Generate a list of	All references relating to this insertion ( 280 )

List References by type	Research paper ( 270 ) Supplementary material ( 7 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Letter ( 1 )
Recent research papers ( 45 )
	Du et al., 2011, PLoS ONE 6(9): e24168 In Vivo RNAi Screen Reveals Neddylation Genes as Novel Regulators of Hedgehog Signaling. [FBrf0215574] Ellis and Carney, 2011, Genetics 187(1): 157--169 Socially-Responsive Gene Expression in Male Drosophila melanogaster Is Influenced by the Sex of the Interacting Partner. [FBrf0212780] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Hijazi et al., 2011, PLoS ONE 6(3): e17763 The ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. [FBrf0213269] Kawamori and Yamaguchi, 2011, Cell Struct. Funct. 36(1): 103--119 DREF is Critical for Drosophila Bristle Development by Regulating Endoreplication in Shaft Cells. [FBrf0213809] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Liu et al., 2011, Dev. Growth Differ. 53(6): 822--841 Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila. [FBrf0214664] Molnar et al., 2011, PLoS Genet. 7(3): e1001335 Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. [FBrf0213301] Morante et al., 2011, Development 138(4): 687--693 Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. [FBrf0212874] O'Keefe et al., 2011, Mech. Dev. 128(1-2): 59--70 EndoGI modulates Notch signaling and axon guidance in Drosophila. [FBrf0213012] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Riedel et al., 2011, Development 138(1): 149--158 Megalin-dependent Yellow endocytosis restricts melanization in the Drosophila cuticle. [FBrf0212536] Terriente-Félix et al., 2011, Dev. Biol. 350(2): 382--392 A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression. [FBrf0212899] Tripura et al., 2011, Int. J. Dev. Biol. 55(6): 583--590 Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila. [FBrf0216296] Wojcinski et al., 2011, Dev. Biol. 358(1): 168--180 DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop. [FBrf0215253] Xie et al., 2011, Insect Biochem. Mol. Biol. 41(3): 167--177 RNAi knockdown of dRNaseZ, the Drosophila homolog of ELAC2, impairs growth of mitotic and endoreplicating tissues. [FBrf0213094] Zamparini et al., 2011, Development 138(18): 4039--4050 Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila. [FBrf0214783] Bejarano et al., 2010, Dev. Biol. 338(1): 63--73 miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only. [FBrf0209786] Bronstein et al., 2010, PLoS Genet. 6(8): e1001063 Transcriptional regulation by CHIP/LDB complexes. [FBrf0211594] Buechling et al., 2010, Curr. Biol. 20(14): 1263--1268 Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor. [FBrf0211368] Cheng et al., 2010, Dev. Biol. 337(1): 99--109 Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. [FBrf0209432] Coleman et al., 2010, Development 137(14): 2417--2426 The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline. [FBrf0211121] de Haro et al., 2010, Cell Tissue Res. 339(2): 321--336 Detailed analysis of leucokinin-expressing neurons and their candidate functions in the Drosophila nervous system. [FBrf0209907] Deng et al., 2010, Mol. Biol. Cell 21(19): 3304--3316 Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos. [FBrf0211962] Djiane and Mlodzik, 2010, PLoS ONE 5(6): e11228 The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. [FBrf0211141] Franke et al., 2010, Dev. Biol. 345(2): 117--132 Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. [FBrf0211576] Furrer et al., 2010, J. Biol. Chem. 285(51): 39623--39636 Drosophila Myc Interacts with Host Cell Factor (dHCF) to Activate Transcription and Control Growth. [FBrf0212501] Hamanaka et al., 2010, Curr. Biol. 20(1): 9--18 Transcriptional Orchestration of the Regulated Secretory Pathway in Neurons by the bHLH protein DIMM. [FBrf0209946] Hermle et al., 2010, Curr. Biol. 20(14): 1269--1276 Regulation of Frizzled-Dependent Planar Polarity Signaling by a V-ATPase Subunit. [FBrf0211335] Hughes et al., 2010, J. Cell Sci. 123(7): 1099--1107 Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity. [FBrf0210408] Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226 Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. [FBrf0214177] Jones et al., 2010, J. Cell Sci. 123(13): 2179--2189 Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. [FBrf0211056] Kleinschmit et al., 2010, Dev. Biol. 345(2): 204--214 Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. [FBrf0211640] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Lu et al., 2010, Genetics 185(2): 549--558 The Drosophila planar polarity proteins inturned and multiple wing hairs interact physically and function together. [FBrf0211207] Mesquita et al., 2010, PLoS Biol. 8(12): e1000566 A dp53-Dependent Mechanism Involved in Coordinating Tissue Growth in Drosophila. [FBrf0212630] Montagne et al., 2010, PLoS Genet. 6: e1000937 The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila. [FBrf0210767] Padash-Barmchi et al., 2010, J. Cell Sci. 123(23): 4052--4062 Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia. [FBrf0212409] Rhiner et al., 2010, Dev. Cell 18(6): 985--998 Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. [FBrf0211273] Song et al., 2010, Genes Dev. 24(9): 881--886 Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling. [FBrf0213249] Tortoriello et al., 2010, FEBS J. 277(15): 3249--3263 Linking pseudouridine synthases to growth, development and cell competition. [FBrf0211423] Usha and Shashidhara, 2010, Dev. Biol. 341(2): 389--399 Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila. [FBrf0210647] Xie et al., 2010, Int. J. Biol. Sci. 6(3): 252--267 NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response. [FBrf0211057] Yan et al., 2010, Development 137(12): 2033--2044 The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. [FBrf0210906] Show all research papers ...

Dmel\P{GawB}apmd544 Insertion

Dmel\P{GawB}ap^md544 Insertion