Dmel\P{lArB}rut^MB1951 Insertion

General Information
Symbol	Dmel\P{lArB}rut^MB1951	Species	D. melanogaster
Name		FlyBase ID	FBti0003268
Feature type	transposable_element_insertion_site
Description
Inserted element	P{lArB}	Expression data	lacZ reporter
Affected gene(s)	Ecol\lacZ, rut	Viability / fertility
Causes allele(s)	Ecol\lacZ^rut-MB1951, rut^MB1951	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	X ( 12F4-12F5 )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
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FB2013_03
FB2013_02
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Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	12F4-12F5 ( near gene of known cytology )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{lArB}
Location-dependent role	lacZ enhancer trap (Wilson et al., 1989)
Size	18.327Kb
Associated alleles	Adh^+t3.2 Ecol\lacZ^P\T.A92a ry^+t7.2
Molecular map
Affected Gene(s)
Insertion may affect gene	Ecol\lacZ (Levin et al., 1992, Han et al., 1992, Han et al., 1996) rut (Han et al., 1992)
Alleles and Phenotypes
Causes alleles	Ecol\lacZ^rut-MB1951 (Levin et al., 1992, Han et al., 1992, Han et al., 1996) rut^MB1951 (Han et al., 1992, Han et al., 1996)

Lethality References
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference Complements rut¹ for initial learning defect, but not for 60 minute retention tests. (Han et al., 1992) Mild defects in initial learning and in 60 minute memory retention, measured in negatively reinforced olfactory discrimination paradigm. (Han et al., 1992)
Expression Data
Reporter Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage mushroom body (Han et al., 1992) adult stage optic lobe (Han et al., 1992) adult brain (Han et al., 1992) distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference adult stage lamina (Han et al., 1996) retina (Han et al., 1996) medulla (Han et al., 1996) thoracico-abdominal ganglion (Han et al., 1992) adult brain cortex (Han et al., 1996) lobula (Han et al., 1996) subesophageal ganglion (Han et al., 1992) adult mushroom body (Han et al., 1992, Han et al., 1996, Levin et al., 1992)
Additional Information
Statement Reference Within the adult brain, highest levels of expression in the corpora pedunculata (mushroom bodies). (Han et al., 1996) Ecol\lacZ is expressed at high levels inthe mushroom body perikarya and at lower levels in most cells of thecentral brain, the optic lobes, the subesophageal ganglion and thethoracic/abdominal ganglia. (Han et al., 1992) Enhancer trap expression is observed in the mushroom bodies. (Levin et al., 1992)

Marker for
Reflects expression of	rut (Han et al., 1996)
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{lArB}rut^MB1951 (Han et al., 1992, Han et al., 1996, FlyBase, 1992-)
Secondary FlyBase IDs

References ( 5 )
Research paper	Han et al., 1996, J. Neurobiol. 31(1): 88--102 The Drosophila brain revisited by enhancer detection. [FBrf0089671] Han et al., 1992, Neuron 9: 619--627 Preferential expression of the Drosophila rutabaga gene in mushroom bodies, neural centers for learning in insects. [FBrf0057366] Levin et al., 1992, Cell 68: 479--489 The Drosophila learning and memory gene rutabaga encodes a Ca²⁺/Calmodulin-responsive adenylyl cyclase. [FBrf0055565] Wilson et al., 1989, Genes Dev. 3(9): 1301--1313 P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. [FBrf0049802]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Dmel\P{lArB}rutMB1951 Insertion

Dmel\P{lArB}rut^MB1951 Insertion