Dmel\P{GawB}sca^537.4 Insertion

General Information
Symbol	Dmel\P{GawB}sca^537.4	Species	D. melanogaster
Name		FlyBase ID	FBti0003347
Feature type	transposable_element_insertion_site
Description
Inserted element	P{GawB}	Expression data	GAL4 reporter/driver
Affected gene(s)	sca, Scer\GAL4	Viability / fertility
Causes allele(s)	sca^537.4, Scer\GAL4^sca-537.4	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	2R ( 49C3-49D3 )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	49C3-49D3 ( near gene of known cytology )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{GawB}
Location-dependent role	GAL4 driver/enhancer trap (Brand and Perrimon, 1993)
Size	11.279Kb
Associated alleles	Scer\GAL4^wB w^+mW.hs
Molecular map
Affected Gene(s)
Insertion may affect gene	sca (Klaes et al., 1994, Nakao and Campos-Ortega, 1996) Scer\GAL4 (Mummery-Widmer et al., 2009, Shalaby et al., 2009, Klaes et al., 1994, Nakao and Campos-Ortega, 1996, Baines et al., 1999, Pi et al., 2001, Apitz et al., 2005, Chien et al., 1998, Pielage et al., 2005, Kidd and Lieber, 2002, Negre et al., 2003, Song et al., 2002, Lai et al., 2005, Badenhorst, 2001, Heeger et al., 2005, Kanuka et al., 1999, Dworak et al., 2001, Wildonger and Mann, 2005, Yu et al., 1998, Shigenaga et al., 1997, Kumar et al., 2001, Renaud and Simpson, 2001, Kidd et al., 1998, Speicher et al., 1998, del Alamo et al., 2002, Niwa et al., 2002, Lee and Jones, 2005, Rozowski and Akam, 2002, Menne et al., 1997, Lai et al., 2001, Katanaev and Tomlinson, 2006, Yeh et al., 2001, Koelzer and Klein, 2003, Sprecher et al., 2006, Egger et al., 2002, Soustelle et al., 2002, Alfonso and Jones, 2002, Renaud and Simpson, 2002, Bourouis, 2002, Bossing et al., 2002, Veraksa et al., 2002, Held, 2002, Jafar-Nejad et al., 2003, Le Gall and Giniger, 2004, Uhler et al., 2002, Karandikar et al., 2004, Igaki et al., 2002, Barolo et al., 2002, Georgiou and Tear, 2003, Rawlins et al., 2003, Escudero et al., 2003, De Joussineau et al., 2003, Hinz et al., 1994, Certel et al., 2000, Baines et al., 2001, Deuring et al., 2000, Rusten et al., 2001, Monge et al., 2001, Lai and Rubin, 2001, Yeh et al., 2000, Simpson et al., 2000, Garcia-Alonso et al., 2000, Nagel et al., 2000, Lai et al., 2000, Huang et al., 2000, Baines et al., 1999, Bashaw et al., 2000, Schock et al., 1999, Abdelilah-Seyfried et al., 2000, Martin-Blanco et al., 1999, Lanoue and Jacobs, 1999, Labourier et al., 1999, Sawamoto et al., 1999, Kidd et al., 1999, Kim et al., 1998, Noordermeer et al., 1998, Chou et al., 1999, Daniel et al., 1999, Chen and Chien, 1999, Battye et al., 1999, Berger et al., 2005, Reifegerste et al., 1999, Escudero et al., 2005, Crisp and Merriam, 1997, Doherty et al., 1997, Isshiki et al., 1997, Wang et al., 1997, Kuzin et al., 2005, Kuzin et al., 2005, Ejima et al., 2004, Sprecher et al., 2004, Sherwood et al., 2004, Tanaka et al., 2004, Merdes et al., 2004, Kammermeier et al., 2001, Chu et al., 1998, Udolph et al., 2001, Akiyama-Oda et al., 1998, Stebbins and Yin, 2001, Lu et al., 1998, Kataoka et al., 2001, Hosoya et al., 1995, Cai et al., 2001, Grillenzoni et al., 1998, Baines and Bate, 1998, Baker et al., 1996, Dormand and Brand, 1998, Iwai et al., 1997, Giesen et al., 1997, Harris et al., 1996, Dittrich et al., 1997, Giebel et al., 1997, Giebel and Campos-Ortega, 1997, Zeng et al., 1998, Parras et al., 1996, Bogdan and Klambt, 2003, Thor and Thomas, 1997, Schreiber-Agus et al., 1997, Mitchell et al., 1996, Schweisguth, 1999, Yoshiyama et al., 2006, Li and Baker, 2004, Bossing and Brand, 2006, Bose et al., 2006, Urbach et al., 2006, Bogdan et al., 2005, von Hilchen et al., 2010, Kim et al., 2012, Quijano et al., 2011, Fontana and Posakony, 2009, Pielage et al., 2008, Babaoglan et al., 2009, Tang et al., 2005, Ayyar et al., 2007, Hartmann et al., 2010, Scully et al., 1999, Commisso and Boulianne, 2007, Schittenhelm et al., 2010, Song et al., 2010, Ayyar et al., 2010, Djiane et al., 2011, Rebeiz et al., 2011, Yamasaki et al., 2011, Song and Lu, 2012, Kaspar et al., 2008, Yogev et al., 2010, Commisso and Boulianne, 2008, Balakireva et al., 2006, Jeong et al., 2012, Kahali et al., 2009, Wang et al., 2008, Choksi et al., 2006)
Alleles and Phenotypes
Causes alleles	sca^537.4 (Klaes et al., 1994, Klaembt, 1995.8.1) Scer\GAL4^sca-537.4 (Klaes et al., 1994, Nakao and Campos-Ortega, 1996, Baines et al., 1999, Pi et al., 2001, Apitz et al., 2005, Chien et al., 1998, Pielage et al., 2005, Kidd and Lieber, 2002, Negre et al., 2003, Song et al., 2002, Mummery-Widmer et al., 2009, Lai et al., 2005, Badenhorst, 2001, Heeger et al., 2005, Kanuka et al., 1999, Dworak et al., 2001, Wildonger and Mann, 2005, Yu et al., 1998, Shigenaga et al., 1997, Kumar et al., 2001, Renaud and Simpson, 2001, Kidd et al., 1998, Speicher et al., 1998, del Alamo et al., 2002, Niwa et al., 2002, Lee and Jones, 2005, Rozowski and Akam, 2002, Menne et al., 1997, Lai et al., 2001, Katanaev and Tomlinson, 2006, Yeh et al., 2001, Koelzer and Klein, 2003, Sprecher et al., 2006, Egger et al., 2002, Soustelle et al., 2002, Alfonso and Jones, 2002, Renaud and Simpson, 2002, Bourouis, 2002, Bossing et al., 2002, Veraksa et al., 2002, Held, 2002, Jafar-Nejad et al., 2003, Le Gall and Giniger, 2004, Uhler et al., 2002, Karandikar et al., 2004, Igaki et al., 2002, Barolo et al., 2002, Georgiou and Tear, 2003, Rawlins et al., 2003, Escudero et al., 2003, De Joussineau et al., 2003, Hinz et al., 1994, Certel et al., 2000, Baines et al., 2001, Deuring et al., 2000, Rusten et al., 2001, Monge et al., 2001, Lai and Rubin, 2001, Yeh et al., 2000, Simpson et al., 2000, Garcia-Alonso et al., 2000, Nagel et al., 2000, Lai et al., 2000, Huang et al., 2000, Baines et al., 1999, Bashaw et al., 2000, Schock et al., 1999, Abdelilah-Seyfried et al., 2000, Martin-Blanco et al., 1999, Lanoue and Jacobs, 1999, Labourier et al., 1999, Sawamoto et al., 1999, Kidd et al., 1999, Kim et al., 1998, Noordermeer et al., 1998, Chou et al., 1999, Daniel et al., 1999, Chen and Chien, 1999, Battye et al., 1999, Berger et al., 2005, Reifegerste et al., 1999, Escudero et al., 2005, Crisp and Merriam, 1997, Doherty et al., 1997, Isshiki et al., 1997, Wang et al., 1997, Kuzin et al., 2005, Kuzin et al., 2005, Ejima et al., 2004, Sprecher et al., 2004, Sherwood et al., 2004, Tanaka et al., 2004, Merdes et al., 2004, Kammermeier et al., 2001, Chu et al., 1998, Udolph et al., 2001, Akiyama-Oda et al., 1998, Stebbins and Yin, 2001, Lu et al., 1998, Kataoka et al., 2001, Hosoya et al., 1995, Cai et al., 2001, Grillenzoni et al., 1998, Baines and Bate, 1998, Baker et al., 1996, Dormand and Brand, 1998, Iwai et al., 1997, Giesen et al., 1997, Harris et al., 1996, Dittrich et al., 1997, Giebel et al., 1997, Giebel and Campos-Ortega, 1997, Zeng et al., 1998, Parras et al., 1996, Bogdan and Klambt, 2003, Thor and Thomas, 1997, Schreiber-Agus et al., 1997, Mitchell et al., 1996, Schweisguth, 1999, Yoshiyama et al., 2006, Li and Baker, 2004, Bossing and Brand, 2006, Shalaby et al., 2009, Bose et al., 2006, Urbach et al., 2006, Bogdan et al., 2005, von Hilchen et al., 2010, Kim et al., 2012, Quijano et al., 2011, Fontana and Posakony, 2009, Pielage et al., 2008, Babaoglan et al., 2009, Tang et al., 2005, Ayyar et al., 2007, Hartmann et al., 2010, Scully et al., 1999, Commisso and Boulianne, 2007, Schittenhelm et al., 2010, Song et al., 2010, Ayyar et al., 2010, Djiane et al., 2011, Rebeiz et al., 2011, Yamasaki et al., 2011, Song and Lu, 2012, Kaspar et al., 2008, Yogev et al., 2010, Commisso and Boulianne, 2008, Balakireva et al., 2006, Jeong et al., 2012, Kahali et al., 2009, Wang et al., 2008, Choksi et al., 2006)

Lethality References
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference Very weak hypomorphic sca phenotype. (Klaembt, 1995.8.1)
Expression Data
Reporter Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage \| mid neuroblast (Klaes et al., 1994) embryonic stage \| late neuron (Klaes et al., 1994) distribution deduced from reporter (Gal4 UAS) Stage Tissue/Position (including subcellular localization) Reference larval stage proneural cluster \| subset (Lai et al., 2000) wing disc \| restricted (Lai et al., 2000) proneural cluster of wing disc (Lai et al., 2000) third instar larval stage sensory mother cell \| subset (Jafar-Nejad et al., 2003) sensory mother cell of wing disc (Jafar-Nejad et al., 2003) wing disc \| restricted (Jafar-Nejad et al., 2003) adult stage intrinsic neuron \| subset (Kitamoto, 2002) adult mushroom body (Kitamoto, 2002) mushroom body intrinsic neuron (Kitamoto, 2002)
Additional Information
Statement Reference Expression is observed in proneural clusters in the wing disc. (Lai et al., 2000)

Marker for	mushroom body (Kitamoto, 2002) proneural cluster <of> dorsal mesothoracic disc (Lai et al., 2000) sensory organ precursor cell <of> dorsal mesothoracic disc (Jafar-Nejad et al., 2003)
Reflects expression of	sca (Klaes et al., 1994, Lai et al., 2000)
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	G537.4 (Mummery-Widmer et al., 2009) Gal4^537.4 (Hinz et al., 1994) P[scab-GAL4] (Battye et al., 1999) P[sca-GAL4] (Lanoue and Jacobs, 1999) P{GawB}537.4 (FlyBase, 1992-) P{GawB}sca^537.4 (Nakao and Campos-Ortega, 1996, FlyBase, 1992-) P{GawB}sca^H (FlyBase, 1992-) sac-GAL4 (Schock et al., 1999) sca::Gal4 (Sprecher et al., 2004, Sprecher et al., 2006) Sca::Gal4 (De Joussineau et al., 2003) Sca.Gal4 (Quijano et al., 2011) sca(537.4)-Gal4 (Bourouis, 2002) sca^537.4 (Commisso and Boulianne, 2007, Commisso and Boulianne, 2008) sca^537.4-GAL4 (Renaud and Simpson, 2001) sca^537.4 Gal4 (Ayyar et al., 2010) Scabous-GAL4 (Song and Lu, 2012) scabrous^537.4Gal4 (Ayyar et al., 2007) scabrous^537.4-Gal4 (Djiane et al., 2011) scabrous-GAL4 (Kuzin et al., 2005, Kuzin et al., 2005, Le Gall and Giniger, 2004, Bogdan and Klambt, 2003, Egger et al., 2002, Yeh et al., 2001, Noordermeer et al., 1998, Yoshiyama et al., 2006, Babaoglan et al., 2009, Choksi et al., 2006) Scabrous GAL4 (Baines et al., 2001) scabrousGAL4 (Bashaw et al., 2000, Commisso and Boulianne, 2007, Commisso and Boulianne, 2008) scabrous GAL4 (Baines et al., 1999, Baines et al., 1999) scabrous-Gal4 (Shalaby et al., 2009) ScaG4 (Li and Baker, 2004) sca-GAL (Niwa et al., 2002) scaGAL (Hosoya et al., 1995) sca-Gal4 (Katanaev and Tomlinson, 2006, Lee and Jones, 2005, Escudero et al., 2005, Tanaka et al., 2004, Jafar-Nejad et al., 2003, Escudero et al., 2003, Rawlins et al., 2003, Held, 2002, Alfonso and Jones, 2002, Kumar et al., 2001, Lai et al., 2001, Badenhorst, 2001, Stebbins and Yin, 2001, Udolph et al., 2001, Lai et al., 2000, Abdelilah-Seyfried et al., 2000, Reifegerste et al., 1999, Urbach et al., 2006, Apitz et al., 2005, von Hilchen et al., 2010, Shalaby et al., 2009, Pielage et al., 2008, Hartmann et al., 2010, Song et al., 2010, Yamasaki et al., 2011, Wang et al., 2008, Kim et al., 2012) Sca-GAL4 (Heeger et al., 2005, Jeong et al., 2012) ScaGAL4 (Simpson et al., 2000) scaGAL-4 (Martin-Blanco et al., 1999) scaGAL4 (Daniel et al., 1999, Commisso and Boulianne, 2007, Commisso and Boulianne, 2008) sca-GAL4 (Mummery-Widmer et al., 2009, Bossing and Brand, 2006, Bogdan et al., 2005, Rebeiz et al., 2011, Fontana and Posakony, 2009, Scully et al., 1999, Schittenhelm et al., 2010, Balakireva et al., 2006) scaGal4 (Li and Baker, 2004, Bose et al., 2006, Ayyar et al., 2007, Kahali et al., 2009, Kaspar et al., 2008) ScaGal4 (Tang et al., 2005) Sca-Gal4 (Yogev et al., 2010)
Secondary FlyBase IDs
	FBti0002146 FBti0002362
References ( 157 )

Generate a list of	All references relating to this insertion ( 157 )

List References by type	Research paper ( 153 ) Supplementary material ( 2 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 )
Recent research papers ( 7 )
	Jeong et al., 2012, Neuron 76(4): 721--734 The Control of Semaphorin-1a-Mediated Reverse Signaling by Opposing Pebble and RhoGAPp190 Functions in Drosophila. [FBrf0219982] Kim et al., 2012, PLoS ONE 7(4): e34016 Negative Regulation of EGFR/MAPK Pathway by Pumilio in Drosophila melanogaster. [FBrf0218126] Song and Lu, 2012, J. Biol. Chem. 287(21): 17716--17728 Interaction of Notch Signaling Modulator Numb with α-Adaptin Regulates Endocytosis of Notch Pathway Components and Cell Fate Determination of Neural Stem Cells. [FBrf0218342] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Rebeiz et al., 2011, Development 138(2): 215--225 Notch regulates numb: integration of conditional and autonomous cell fate specification. [FBrf0212636] Yamasaki et al., 2011, Genes Cells 16(8): 896--909 Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy. [FBrf0214536] Show all research papers ...

Dmel\P{GawB}sca537.4 Insertion

Dmel\P{GawB}sca^537.4 Insertion