Dmel\P{lArB}A507.2M2 Insertion

General Information
Symbol	Dmel\P{lArB}A507.2M2	Species	D. melanogaster
Name		FlyBase ID	FBti0003389
Feature type	transposable_element_insertion_site
Description
Inserted element	P{lArB}	Expression data	lacZ reporter
Affected gene(s)	Ecol\lacZ	Viability / fertility
Causes allele(s)	Ecol\lacZ^esg-A507.2M2	Stock availability	2 publicly available
LINE ID
Genomic Location
Chromosomal location	2L ( 35D-35E )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)
Cytological location (reported)	35D--35E (in situ hybridization reported) (Bellen and Gehring, 1999.8.1) 35D-35E (in situ hybridization reported) (Bellen et al., 1989)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{lArB}
Location-dependent role	lacZ enhancer trap (Wilson et al., 1989)
Size	18.327Kb
Associated alleles	Adh^+t3.2 Ecol\lacZ^P\T.A92a ry^+t7.2
Molecular map
Affected Gene(s)
Insertion may affect gene	Ecol\lacZ (Bellen et al., 1989, Staab et al., 1996, Bellen, 1998.8.10, Heller and Steinmann-Zwicky, 1998, Roote, 1996.9.24, Heller and Steinmann-Zwicky, 1998, Arbouzova and Zeidler, 2006, Wawersik et al., 2005, Streit et al., 2002)
Alleles and Phenotypes
Causes alleles	Ecol\lacZ^esg-A507.2M2 (Bellen et al., 1989, Staab et al., 1996, Bellen, 1998.8.10, Heller and Steinmann-Zwicky, 1998, Roote, 1996.9.24, Heller and Steinmann-Zwicky, 1998, Arbouzova and Zeidler, 2006, Wawersik et al., 2005, Streit et al., 2002)

Lethality References
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference
Expression Data
Reporter Expression
distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference embryonic stage 15 & male -- 17 & male male germline cell (Streit et al., 2002) embryonic stage 17 pole cell (Bellen et al., 1989) embryonic/larval posterior spiracle (Bellen et al., 1989) embryonic brain (Bellen et al., 1989) adult stage \| male male germline cell (Streit et al., 2002)
Additional Information
Statement Reference In ovary, no detectable Ecol\lacZ expression. (Bellen, 1998.8.10)

Marker for	male germline cell (Streit et al., 2002)
Reflects expression of
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer	CyO-A507 (Bellen and Gehring, 1999.8.1, Bloomington Drosophila Stock Center, 1998.9.24, Roote, 1996.9.24, FlyBase Curators, 2006-)
Stocks ( 2 )
Bloomington	11033 CyO, P{lArB}A507.2M2, chif^A507/b¹ Adh^* cn^* l(2)^; ry⁵⁰⁶
Kyoto	108984 CyO, P{lArB}A507.2M2, chif^A507/b¹ Adh^* cn^* l(2)^; ry⁵⁰⁶
Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	A507.2M2 (Bellen et al., 1989, Streit et al., 2002) mgm-1 (Wawersik et al., 2005) mgm1 (Streit et al., 2002) P{lArB}A507.2M2 (Staab et al., 1996, FlyBase, 1992-) P{ry^+t7.2=lArB}A507.2M2 (FlyBase, 1992-)
Secondary FlyBase IDs
	FBti0000852
References ( 14 )
Research paper	Wawersik et al., 2005, Nature 436(7050): 563--567 Somatic control of germline sexual development is mediated by the JAK/STAT pathway. [FBrf0188143] Streit et al., 2002, Int. J. Dev. Biol. 46(1 Spec No): 159--166 mgm1, the earliest sex-specific germline marker in Drosophila, reflects expression of the gene esg in male stem cells. [FBrf0147086] Heller and Steinmann-Zwicky, 1998, Mech. Dev. 73(2): 203--209 In Drosophila, female gonadal cells repress male-specific gene expression in XX germ cells. [FBrf0102745] Heller and Steinmann-Zwicky, 1998, Mech. Dev. 72(1,2): 169--173 No premature gene expression in germ cells of embryos deriving from nos females. [FBrf0102183] Staab et al., 1996, Development 122(12): 4065--4071 Somatic sex-determining signals act on XX germ cells in Drosophila embryos. [FBrf0091303] Bellen et al., 1989, Genes Dev. 3: 1288--1300 P-element-mediated enhancer detection: a versatile method to study development in Drosophila. [FBrf0049801] Wilson et al., 1989, Genes Dev. 3(9): 1301--1313 P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. [FBrf0049802]
Review	Arbouzova and Zeidler, 2006, Development 133(14): 2605--2616 JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions. [FBrf0193685]
Personal communication to FlyBase	Bellen and Gehring, 1999.8.1, Insertions and alleles. Insertions and alleles. [FBrf0122636] Bellen, 1998.8.10, Patterns of insertions of lacZ reporter constructs. Patterns of insertions of lacZ reporter constructs. [FBrf0103137] Bloomington Drosophila Stock Center, 1998.9.24, CyO and TM2 variants. CyO and TM2 variants. [FBrf0104934] Roote, 1996.9.24, A507 mutant for chiffon? A507 mutant for chiffon? [FBrf0089995]
FlyBase analysis	FlyBase Curators, 2006-, Balancer summary information. Balancer summary information. [FBrf0189689] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]