A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Dmel\P{GawB}egMz360 Insertion

General Information
Symbol Dmel\P{GawB}egMz360 Species D. melanogaster
Name FlyBase ID FBti0004369
Feature type transposable_element_insertion_site
Description
Inserted element P{GawB} Expression data GAL4 reporter/driver
Affected gene(s) eg, Scer\GAL4 Viability / fertility
Causes allele(s) egMz360, Scer\GAL4eg-Mz360 Stock availability 1 publicly available
LINE ID
Genomic Location
Chromosomal location 3L ( 78F2-78F3 ) Sequence location
Member of Large Scale Dataset(s)
Dataset
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Description
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FB2013_03
FB2013_02
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hide Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location
(computed by FlyBase)
78F2-78F3 ( near gene of known cytology )
Cytological location
(reported)
Comments concerning
location
hide Sequence Data
Flanking sequence
hide Inserted Element
Construct P{GawB}
Location-dependent
role
GAL4 driver/enhancer trap
(Brand and Perrimon, 1993)
Size 11.279Kb
Associated alleles
Scer\GAL4wB
w+mW.hs
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
eg
(Ito et al., 1995)
Scer\GAL4
(Girard et al., 2006, Ito et al., 1995, Bonkowsky et al., 1999, Lundell et al., 2003, Keleman and Dickson, 2001, Yoshikawa et al., 2003, Novotny et al., 2002, Fradkin et al., 2004, Couch et al., 2004, Georgiou and Tear, 2002, Urban et al., 1993, Yoshikawa et al., 2001, Akiyama-Oda et al., 2000, Akiyama-Oda et al., 2000, Schmidt et al., 1997, Wojtowicz et al., 2004, Ragone et al., 2001, Dormand and Brand, 1998, Dittrich et al., 1997, Layden et al., 2006, Garbe et al., 2007, Simionato et al., 2007, Joly et al., 2007, Al-Anzi et al., 2009, Garbe et al., 2007, Yang et al., 2009, Tsuji et al., 2008, Losada-Pérez et al., 2010, Brankatschk and Dickson, 2006, Funada et al., 2007, Coleman et al., 2010, Jepson et al., 2011)
hide Alleles and Phenotypes
Causes alleles
egMz360
(Dittrich et al., 1997, Sykes and Condron, 2005, Couch et al., 2004, Urban et al., 1993)
Scer\GAL4eg-Mz360
(Ito et al., 1995, Bonkowsky et al., 1999, Lundell et al., 2003, Keleman and Dickson, 2001, Yoshikawa et al., 2003, Novotny et al., 2002, Fradkin et al., 2004, Couch et al., 2004, Georgiou and Tear, 2002, Urban et al., 1993, Yoshikawa et al., 2001, Akiyama-Oda et al., 2000, Akiyama-Oda et al., 2000, Schmidt et al., 1997, Wojtowicz et al., 2004, Ragone et al., 2001, Dormand and Brand, 1998, Dittrich et al., 1997, Layden et al., 2006, Girard et al., 2006, Garbe et al., 2007, Simionato et al., 2007, Joly et al., 2007, Al-Anzi et al., 2009, Garbe et al., 2007, Yang et al., 2009, Tsuji et al., 2008, Losada-Pérez et al., 2010, Brankatschk and Dickson, 2006, Funada et al., 2007, Coleman et al., 2010, Jepson et al., 2011)
Lethality
References
viable
(Dittrich et al., 1997)
Sterility
References
hide Phenotype Manifest In
EW1 neuron
(Lundell and Hirsh, 1998)
serotonergic neuron
(Lundell and Hirsh, 1998)
serotonin neuron & ventral nerve cord
(Couch et al., 2004)
wing
(Gritzan et al., 2002, Dittrich et al., 1997)
hide Detailed Description
Statement
Reference
In the ventral nerve cords from stage 16 egMz360/egMz360 embryos, the number of hemisegments showing loss of ability to take up serotonin is not significantly increased by leaX123/leaX123. Loss of serotonin uptake activity in the ventral nerve cords of stage 16 egMz360/egMz360 embryos is suppressed by the presence of leaEP2582/leaEP2582.
(Couch et al., 2004)
In the ventral nerve cords of stage 16 egMz360 mutant embryos, there is a loss of ability to take up serotonin in approximately 1/4 of hemisegments.
(Couch et al., 2004)
Homozygotes have a held out wing phenotype.
(Gritzan et al., 2002)
Mutants exhibit an almost wild type pattern of serotonin neurons in the abdominal region but only single cells in the thoracic segments. nub and zfh2 staining reveals the more medial serotonin cell of the mitotic pair is lost: the EW1 neuron.
(Lundell and Hirsh, 1998)
Homozygotes have a \'wings held out\' phenotype.
(Dittrich et al., 1997)
hide Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage | late  
CNS glial cell | restricted  
(Ito et al., 1995)
presumptive embryonic/larval central nervous system | restricted  
(Ito et al., 1995)
embryonic/larval cell body glial cell  
(Ito et al., 1995)
embryonic stage  
neuroblast NB3-3  
(Tsuji et al., 2008)
embryonic stage 11  
serotonergic neuron | precursor  
(Lundell and Hirsh, 1998)
first instar larval stage  
glial cell of embryonic/larval central nervous system  
(Ito et al., 1995)
embryonic/larval central nervous system | restricted  
(Ito et al., 1995)
second instar larval stage  
neuroblast | subset  
(Tsuji et al., 2008)
third instar larval stage  
neuroblast | subset  
(Tsuji et al., 2008)
Additional Information
Statement
Reference
Expression pattern is similar to that of P{lArB}egP289.
(Lundell and Hirsh, 1998)
Expression in glial cells not exclusive, expressed in other tissues as well.
(Ito et al., 1995)
Marker for
neuroblast NB3-3
(Tsuji et al., 2008)
serotonin neuron | precursor
(Lundell and Hirsh, 1998)
Reflects
expression of
eg
(Lundell and Hirsh, 1998)
Reporter construct
used in assay
nabScer\UAS.cFa
(Tsuji et al., 2008)
pdm2Scer\UAS.T:Ivir\HA1
(Tsuji et al., 2008)
sqzScer\UAS.cTa
(Tsuji et al., 2008)
hide External Images
FlyView (LinkOut)
hide Data on Genetic Line
Line ID
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
8758
w*; P{GawB}egMz360
hide Linkouts
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
eagleGal4
(Novotny et al., 2002, Couch et al., 2004, Garbe et al., 2007)
eagle-GAL4
(Ragone et al., 2001)
eagle-gal4
(Layden et al., 2006)
eagle-Gal4
(Girard et al., 2006, Joly et al., 2007, Losada-Pérez et al., 2010)
eagleGAL4
(Garbe et al., 2007)
eg-Gal4
(Wojtowicz et al., 2004, Joly et al., 2007, Losada-Pérez et al., 2010)
Eg-GAL4
(Fradkin et al., 2004, Georgiou and Tear, 2002)
eg-gal4
(Lundell et al., 2003, Funada et al., 2007)
eg-GAL4
(Yoshikawa et al., 2003, Keleman and Dickson, 2001, Yoshikawa et al., 2001, Bonkowsky et al., 1999, Akiyama-Oda et al., 2000, Simionato et al., 2007, Brankatschk and Dickson, 2006)
Eg-Gal4
(Al-Anzi et al., 2009)
egGAL4
(Coleman et al., 2010)
eglGal4
(Yang et al., 2009)
MZ360
(Georgiou and Tear, 2002, Akiyama-Oda et al., 2000, Akiyama-Oda et al., 2000)
mz360
(Jepson et al., 2011)
MZ360-eagle-GAL4
(Tsuji et al., 2008)
P{GawB}egMz360
(Ito et al., 1995, FlyBase, 1992-)
Secondary FlyBase IDs
hide References ( 37 )
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hide Recent research papers ( 1 )
Jepson et al., 2011, J. Biol. Chem. 286(10): 8325--8337
Engineered Alterations in RNA Editing Modulate Complex Behavior in Drosophila: REGULATORY DIVERSITY OF ADENOSINE DEAMINASE ACTING ON RNA (ADAR) TARGETS. [FBrf0213236]
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