A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Dmel\P{PZ}gsb01155 Insertion

General Information
Symbol Dmel\P{PZ}gsb01155 Species D. melanogaster
Name FlyBase ID FBti0004819
Feature type transposable_element_insertion_site
Description
Inserted element P{PZ} Expression data
Affected gene(s) Ecol\lacZ, gsb Viability / fertility
Causes allele(s) Ecol\lacZgsb-01155, gsb01155 Stock availability 1 publicly available
LINE ID l(2)01155
Genomic Location
Chromosomal location 2R ( 60F2 ) Sequence location
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Description
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location
(computed by FlyBase)
60F2 ( near gene of known cytology )
Cytological location
(reported)
60F1-60F3 (in situ hybridization reported)
(BDGP Project Members, 1994-1999)
Comments concerning
location
hide Sequence Data
Flanking sequence
AQ073261
 
hide Inserted Element
Construct P{PZ}
Location-dependent
role
lacZ enhancer trap
(Mlodzik and Hiromi, 1992)
Size 14.545Kb
Associated alleles
Ecol\lacZP\T.PZ
l(3)87Df7.2
ry+t7.2
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
Ecol\lacZ
(BDGP Project Members, 1994-1999, Vosshall, 1998.8.10, Baumgardt et al., 2007, Baumgardt et al., 2009, Losada-Pérez et al., 2010, Marie et al., 2010)
gsb
(Duman-Scheel et al., 1997, Marie et al., 2010)
hide Alleles and Phenotypes
Causes alleles
Ecol\lacZgsb-01155
(BDGP Project Members, 1994-1999, Vosshall, 1998.8.10, Baumgardt et al., 2007, Baumgardt et al., 2009, Losada-Pérez et al., 2010, Marie et al., 2010)
gsb01155
(Duman-Scheel et al., 1997, BDGP Project Members, 1994-1999, De Graeve et al., 2004, FlyBase, 1996-, Spradling et al., 1999, Marie et al., 2010)
Lethality
References
lethal | embryonic stage | recessive
(Perrimon et al., 1996)
lethal | recessive
(Spradling et al., 1999)
Sterility
References
hide Phenotype Manifest In
cuticle
(Perrimon et al., 1996)
denticle belt
(Perrimon et al., 1996)
posterior commissure
(Duman-Scheel et al., 1997)
RP2 neuron
(Duman-Scheel et al., 1997)
U1 neuron
(Duman-Scheel et al., 1997)
U2 neuron
(Duman-Scheel et al., 1997)
U3 neuron
(Duman-Scheel et al., 1997)
U neuron
(Duman-Scheel et al., 1997)
hide Detailed Description
Statement
Reference
Motoneurons in gsb[01155]/+ heterozygotes navigate into the periphery and establish the correct stereotyped pattern of synaptic connections with particular muscle cells. Synaptic transmission is normal in gsb[01155]/+ heterozygotes.
(Marie et al., 2010)
A gsb[01155]/+ heterozygous background significantly suppresses the magnitude of synaptic homeostasis that is expressed in a GluRIIA[SP16] mutant background. There is significantly more homeostatic compensation found in wg[l-12]/+ GluRIIA[SP16] ; gsb[01155] compared to wg[l-12]/+ GluRIIA[SP16] mutants. The presence of wg[l-12]/+ restores homeostatic compensation to levels that are statistically the same as those observed in GluRIIA[SP16] single mutants.
(Marie et al., 2010)
Mutants exhibit occasional duplication of RP2 neurons and frequent loss of U and CQ neurons. Posterior commissures are missing or reduced.
(Duman-Scheel et al., 1997)
Germline clones produce eggs with patterning defects: mirror image duplication of denticle belts.
(Perrimon et al., 1996)
hide Expression Data
Reporter Expression
Additional Information
Statement
Reference
Marker for
Reflects
expression of
hide External Images
FlyView (LinkOut)
hide Data on Genetic Line
Line ID
l(2)01155
(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
y
(FlyBase, 1992-)
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
10999
cn1 P{PZ}gsb01155/CyO; ry506
hide Linkouts
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
10999
(De Graeve et al., 2004)
Df(gsb)
(De Graeve et al., 2004)
gooseberry-lacZ
(Losada-Pérez et al., 2010)
gsb01155
(Marie et al., 2010, Losada-Pérez et al., 2010)
gsblacZ
(Baumgardt et al., 2009)
gsb-lacZ
(Losada-Pérez et al., 2010)
P999
(Meister and Braun, 1995.10)
P{PZ}gsb01155
(FlyBase, 1992-)
P{PZ}gsb-d01155
(Duman-Scheel et al., 1997, FlyBase, 1992-)
P{PZ}l(2)0115501155
(FlyBase, 1992-)
P{ry+t7.2=PZ}gsb-d01155
(FlyBase, 1992-)
Secondary FlyBase IDs
  • FBti0000234
hide References ( 16 )
Research paper
Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471
Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045]
Marie et al., 2010, J. Neurosci. 30(24): 8071--8082
Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog. [FBrf0211066]
Baumgardt et al., 2009, Cell 139(5): 969--982
Neuronal subtype specification within a lineage by opposing temporal feed-forward loops. [FBrf0209429]
Baumgardt et al., 2007, PLoS Biol. 5(2):
Specification of neuronal identities by feedforward combinatorial coding. [FBrf0195184]
Bellen et al., 2004, Genetics 167(2): 761--781
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
De Graeve et al., 2004, Dev. Biol. 270(1): 122--134
The ladybird homeobox genes are essential for the specification of a subpopulation of neural cells. [FBrf0174534]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Duman-Scheel et al., 1997, Development 124(15): 2855--2865
Genetic separation of the neural and cuticular patterning functions of gooseberry. [FBrf0094600]
Perrimon et al., 1996, Genetics 144(4): 1681--1692
Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. [FBrf0091142]
Mlodzik and Hiromi, 1992, Conn, 1992: 397--414
Enhancer trap method in Drosophila: its application to neurobiology. [FBrf0066714]
Personal communication to FlyBase
Vosshall, 1998.8.10, Patterns of lacZ expression.
Patterns of lacZ expression. [FBrf0103142]
Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington.
lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
FlyBase analysis
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
FlyBase inference based on genome sequence analysis. [FBrf0104946]
FlyBase, 1992-, FlyBase curation
FlyBase curation. [FBrf0105495]
Computer file
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0067338]