Dmel\P{PZ}Snr1⁰¹³¹⁹ Insertion

General Information
Symbol	Dmel\P{PZ}Snr1⁰¹³¹⁹	Species	D. melanogaster
Name		FlyBase ID	FBti0005425
Feature type	transposable_element_insertion_site
Description
Inserted element	P{PZ}	Expression data	lacZ reporter
Affected gene(s)	Ecol\lacZ, Snr1	Viability / fertility
Causes allele(s)	Ecol\lacZ^Snr1-01319, Snr1⁰¹³¹⁹	Stock availability	1 publicly available
LINE ID	l(3)01319
Genomic Location
Chromosomal location	3R ( 83A4 )	Sequence location	3R:1,297,675..1,297,675 [+]
Map ( GBrowse )
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location	3R:1,297,675..1,297,675 [+] (BDGP Project Members, 1994-1999)
Orientation
Cytological location (computed by FlyBase)	83A4 ( inferred by FlyBase from sequence location )
Cytological location (reported)	83A5-83A6 (in situ hybridization reported) (BDGP Project Members, 1994-1999)
Comments concerning location
Sequence Data
Flanking sequence	AQ026168 (FlyBase, 1992-,
Inserted Element
Construct	P{PZ}
Location-dependent role	lacZ enhancer trap (Mlodzik and Hiromi, 1992)
Size	14.545Kb
Associated alleles	Ecol\lacZ^P\T.PZ l(3)87Df^7.2 ry^+t7.2
Molecular map
Affected Gene(s)
Insertion may affect gene	Ecol\lacZ (Dingwall et al., 1995, Vosshall, 1998.8.10, Russell et al., 1998) Snr1 (Dingwall et al., 1995, Zhu et al., 2008)
Alleles and Phenotypes
Causes alleles	Ecol\lacZ^Snr1-01319 (Dingwall et al., 1995, Vosshall, 1998.8.10, Russell et al., 1998) Snr1⁰¹³¹⁹ (Dingwall et al., 1995, BDGP Project Members, 1994-1999, Brumby et al., 2002, Spradling et al., 1999, Zraly et al., 2003, Zhu et al., 2008)

Lethality References lethal \| larval stage \| recessive (Dingwall et al., 1995) lethal \| recessive (Spradling et al., 1999)
Sterility References
Phenotype Manifest In
	adult antennal lobe projection neuron DL1 adPN (Tea and Luo, 2011)
Detailed Description
Statement Reference PBac{GH146-GAL4.B}-marked anterodorsal single cell clones in Snr1[01319] mutants display mistargeting to non-stereotyped glomeruli throughout the antennal lobe. PBac{GH146-GAL4.B}-marked neuroblast clones in Snr1[01319] mutants display phenotypes where dendrites make small, meandering projections throughout the antennal lobe and exhibit extremely perturbed cell morphology. (Tea and Luo, 2011) Suppresses the CycE^JP rough eye phenotype. (Brumby et al., 2002) The addition of Snr1⁰¹³¹⁹ enhances the eye size phenotype seen in osa^Scer\UAS.cCa/Scer\GAL4^ey.PH flies. (Collins et al., 1999) brm² shows little if any interaction in double heterozygous combination with Snr1⁰¹³¹⁹; less than 3% of flies have held-out wings. (Vazquez et al., 1999)
Expression Data
Reporter Expression
distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference adult stage third segment of antenna (Vosshall, 1998.8.10)
Additional Information
Statement Reference In wandering third instar larva, no detectable β-gal staining. (Meister and Braun, 1995.10)

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID	l(3)01319 (Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 1 )
Bloomington	11529 P{PZ}Snr1⁰¹³¹⁹ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹
Linkouts
Comments
	Location 3R:1297675-1297676 confirmed by FlyBase alignment of dbGSS accession AQ026168 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. (FlyBase, 2005)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{PZ}l(3)01319⁰¹³¹⁹ (FlyBase, 1992-) P{PZ}Snr1⁰¹³¹⁹ (FlyBase, 2005, Dingwall et al., 1995, FlyBase, 1992-) P{PZ}snr1⁰¹³¹⁹ (Dingwall et al., 1995, FlyBase, 1992-) P{ry^+t7.2=PZ}l(3)01319⁰¹³¹⁹ (FlyBase, 1992-) P<up>PZ rg+</up>Snr1⁰¹³¹⁹ (Zhu et al., 2008)
Secondary FlyBase IDs
	FBti0000489 FBti0004070
References ( 17 )
Research paper	Tea and Luo, 2011, Neural Dev. 6: 5 The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting. [FBrf0213006] Zhu et al., 2008, PLoS Genet. 4(2): e1000009 Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis. [FBrf0207924] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132] Zraly et al., 2003, Dev. Biol. 253(2): 291--308 SNR1 is an essential subunit in a subset of Drosophila Brm complexes, targeting specific functions during development. [FBrf0155665] Brumby et al., 2002, EMBO J. 21(13): 3377--3389 Drosophila cyclin E interacts with components of the Brahma complex. [FBrf0151282] Collins et al., 1999, EMBO J. 18(24): 7029--7040 Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes. [FBrf0124978] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Vazquez et al., 1999, Development 126(4): 733--742 The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. [FBrf0107412] Russell et al., 1998, Genome 41(1): 7--13 Lethal P-lacZ insertion lines expressed during pattern respecification in the imaginal discs of Drosophila. [FBrf0102000] Dingwall et al., 1995, Molec. Biol. Cell 6(7): 777--791 The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex. [FBrf0083116] Mlodzik and Hiromi, 1992, Conn, 1992: 397--414 Enhancer trap method in Drosophila: its application to neurobiology. [FBrf0066714]
Personal communication to FlyBase	Vosshall, 1998.8.10, Patterns of lacZ expression. Patterns of lacZ expression. [FBrf0103142] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
FlyBase analysis	FlyBase, 2005, Assessment of transgenic construct insertion sites. Assessment of transgenic construct insertion sites. [FBrf0184339] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]

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