A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Dmel\P{PZ}Atpα01453a Insertion

General Information
Symbol Dmel\P{PZ}Atpα01453a Species D. melanogaster
Name FlyBase ID FBti0005429
Feature type transposable_element_insertion_site
Description
Inserted element P{PZ} Expression data lacZ reporter
Affected gene(s) Atpα, Ecol\lacZ Viability / fertility
Causes allele(s) Atpα01453a, Ecol\lacZAtpα-01453a Stock availability 1 publicly available
LINE ID l(3)01453
Genomic Location
Chromosomal location 3R ( 93A4 ) Sequence location
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Description
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location
(computed by FlyBase)
93A4 ( near gene of known cytology )
Cytological location
(reported)
93B1--93B2 (in situ hybridization reported)
(BDGP Project Members, 1994-1999)
Comments concerning
location
hide Sequence Data
Flanking sequence
hide Inserted Element
Construct P{PZ}
Location-dependent
role
lacZ enhancer trap
(Mlodzik and Hiromi, 1992)
Size 14.545Kb
Associated alleles
Ecol\lacZP\T.PZ
l(3)87Df7.2
ry+t7.2
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
Atpα
(Schwarz, 1996)
Ecol\lacZ
(BDGP Project Members, 1994-1999, Russell et al., 1998, Vosshall, 1998.8.10)
hide Alleles and Phenotypes
Causes alleles
Atpα01453a
(Schwarz, 1996, Spradling et al., 1999, Palladino et al., 2003, BDGP Project Members, 1994-1999, FlyBase, 1996-, Feng et al., 1997)
Ecol\lacZAtpα-01453a
(BDGP Project Members, 1994-1999, Russell et al., 1998, Vosshall, 1998.8.10)
Lethality
References
lethal | embryonic stage
(Palladino et al., 2003)
lethal | embryonic stage | recessive
(Feng et al., 1997)
lethal | recessive
(Spradling et al., 1999, Schwarz and Benzer, 1997, Palladino et al., 2003)
semi-lethal
(Palladino et al., 2003)
semi-viable
(Palladino et al., 2003)
Sterility
References
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
In Atpα01453a homozygous mutants the adherens junction remains intact, with the regular spacing of plasma membranes maintained. However, the septae normally located between these membranes are reduced in number or absent.
(Genova and Fehon, 2003)
hide Expression Data
Reporter Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage  
antennal lobe  
(Vosshall, 1998.8.10)
adult brain | restricted  
(Vosshall, 1998.8.10)
adult central complex  
(Vosshall, 1998.8.10)
Additional Information
Statement
Reference
In wandering third instar larva, no detectable β-gal staining.
(Meister and Braun, 1995.10)
Marker for
Reflects
expression of
hide External Images
FlyView (LinkOut)
hide Data on Genetic Line
Line ID
l(3)01453
(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
11533
ry506 P{PZ}Atpα01453a P{PZ}stg01453b/TM6B, Tb1
hide Linkouts
hide Comments
Originally derived from line carrying multiple insertions.
(BDGP Project Members, 1994-1999)
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
P{PZ}Atpα01453
(Schwarz, 1996, FlyBase, 1992-)
P{PZ}Atpα01453a
(FlyBase, 1992-)
P{PZ}l(3)0145301453
(FlyBase, 1992-)
P{ry+t7.2=PZ}l(3)0145301453
(FlyBase, 1992-)
Secondary FlyBase IDs
  • FBti0000492
hide References ( 15 )
Research paper
Bellen et al., 2004, Genetics 167(2): 761--781
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
Genova and Fehon, 2003, J. Cell Biol. 161(5): 979--989
Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila. [FBrf0160546]
Palladino et al., 2003, J. Neurosci. 23(4): 1276--1286
Neural dysfunction and neurodegeneration in Drosophila Na[+]/K[+] ATPase α subunit mutants. [FBrf0159062]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Russell et al., 1998, Genome 41(1): 7--13
Lethal P-lacZ insertion lines expressed during pattern respecification in the imaginal discs of Drosophila. [FBrf0102000]
Feng et al., 1997, Genes Funct. 1(2): 99--117
The Drosophila Na,K-ATPase -subunit gene: gene structure, promoter function and analysis of a cold-sensitive recessive-lethal mutation. [FBrf0100024]
Schwarz and Benzer, 1997, Proc. Natl. Acad. Sci. USA 94(19): 10249--10254
Calx, a Na-Ca exchanger gene of Drosophila melanogaster. [FBrf0098346]
Mlodzik and Hiromi, 1992, Conn, 1992: 397--414
Enhancer trap method in Drosophila: its application to neurobiology. [FBrf0066714]
Personal communication to FlyBase
Vosshall, 1998.8.10, Patterns of lacZ expression.
Patterns of lacZ expression. [FBrf0103142]
Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington.
lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
FlyBase analysis
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
FlyBase inference based on genome sequence analysis. [FBrf0104946]
FlyBase, 1992-, FlyBase curation
FlyBase curation. [FBrf0105495]
Thesis
Schwarz, 1996, Ph.D. Thesis, California Institute of Technology, CA: xi + 214pp
Calx, a sodium-calcium exchanger of Drosophila melanogaster. [FBrf0093704]
Computer file
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0067338]