Dmel\P{PZ}caps⁰²⁹³⁷ Insertion

General Information
Symbol	Dmel\P{PZ}caps⁰²⁹³⁷	Species	D. melanogaster
Name		FlyBase ID	FBti0005466
Feature type	transposable_element_insertion_site
Description
Inserted element	P{PZ}	Expression data	lacZ reporter
Affected gene(s)	caps, Ecol\lacZ	Viability / fertility
Causes allele(s)	caps⁰²⁹³⁷, Ecol\lacZ^caps-02937	Stock availability	1 publicly available
LINE ID	l(3)02937
Genomic Location
Chromosomal location	3L ( 70A3 )	Sequence location	3L:13,221,680..13,221,680 [+]
Map ( GBrowse )
Recent Updates
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FB2012_01
FB2011_10
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Detailed Mapping Data
Chromosome (arm)
Sequence Location	3L:13,221,680..13,221,680 [+] (BDGP Project Members, 1994-1999)
Orientation
Cytological location (computed by FlyBase)	70A3 ( inferred by FlyBase from sequence location )
Cytological location (reported)	70A1-70A5 (in situ hybridization reported) (BDGP Project Members, 1994-1999)
Comments concerning location
Sequence Data
Flanking sequence	AQ026183 (FlyBase, 1992-) AQ034123 (FlyBase, 1992-,
Inserted Element
Construct	P{PZ}
Location-dependent role	lacZ enhancer trap (Mlodzik and Hiromi, 1992)
Size	14.545Kb
Associated alleles	Ecol\lacZ^P\T.PZ l(3)87Df^7.2 ry^+t7.2
Molecular map
Affected Gene(s)
Insertion may affect gene	caps (BDGP Project Members, 1994-1999) Ecol\lacZ (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Janody et al., 2003, Milan et al., 2001, del Alamo Rodriguez et al., 2004, Vosshall, 1998.8.10, Sakurai et al., 2007, Mao et al., 2008)
Alleles and Phenotypes
Causes alleles	caps⁰²⁹³⁷ (BDGP Project Members, 1994-1999, Abrell and Jackle, 2001, Milan et al., 2001, Abrell et al., 2000, Spradling et al., 1999) Ecol\lacZ^caps-02937 (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Janody et al., 2003, Milan et al., 2001, del Alamo Rodriguez et al., 2004, Vosshall, 1998.8.10, Sakurai et al., 2007, Mao et al., 2008)

Lethality References lethal \| recessive (Spradling et al., 1999, Abrell and Jackle, 2001)
Sterility References
Phenotype Manifest In
	abdominal RP5 neuron (Abrell and Jackle, 2001) dorsal trunk primordium (Krause et al., 2006)
Detailed Description
Statement Reference caps⁰²⁹³⁷ embryos show discontinuous dorsal trunk formation. (Krause et al., 2006) 64% of homozygous embryos fail to hatch, though all those that do hatch develop into normal looking larvae. Very few (3%) survive to adulthood. In homozygous mutant embryos, the SNb enters the ventral muscle field and the RP neurons defasciculate normally. Furthermore, RP1, RP3 and RP4 properly synapse with their respective target muscles, whereas the RP5 axons stall, show enlarged growth cone like structures and fail to contact the target muscle. Instead the RP5 axons are split and found also in direct contact with the transversal nerve. (Abrell and Jackle, 2001)
Expression Data
Reporter Expression
distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference wandering third instar larval stage imaginal disc (Meister and Braun, 1995.10) epidermis (Meister and Braun, 1995.10) embryonic/larval somatic muscle (Meister and Braun, 1995.10) embryonic/larval foregut (Meister and Braun, 1995.10) embryonic/larval brain (Meister and Braun, 1995.10) embryonic/larval fat body (Meister and Braun, 1995.10) embryonic/larval midgut (Meister and Braun, 1995.10) embryonic/larval hindgut (Meister and Braun, 1995.10) embryonic/larval cuticle (Meister and Braun, 1995.10) embryonic/larval salivary gland (Meister and Braun, 1995.10) adult stage third segment of antenna (Vosshall, 1998.8.10)
Additional Information
Statement Reference Weak β-gal expression in many tissue in wandering third instar larva; stronger expression in the imaginal discs (which discs not specified), the foregut, hindgut, and epidermis. (Meister and Braun, 1995.10)

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID	l(3)02937 (Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 1 )
Bloomington	11579 P{PZ}caps⁰²⁹³⁷ ry⁵⁰⁶/TM3, red^* Ser¹
Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	caps⁰²⁹³⁷ (Sakurai et al., 2007) caps⁰²⁹³⁷-lacZ (del Alamo Rodriguez et al., 2004) caps-lacZ (Janody et al., 2003, Milan et al., 2001, Sakurai et al., 2007, Mao et al., 2008) P1579 (Meister and Braun, 1995.10) P{PZ}caps⁰²⁹³⁷ (FlyBase, 1992-) P{PZ}l(3)02937⁰²⁹³⁷ (BDGP Project Members, 1994-1999, FlyBase, 1992-) P{ry^+t7.2=PZ}l(3)02937⁰²⁹³⁷ (FlyBase, 1992-)
Secondary FlyBase IDs
	FBti0000524
References ( 16 )
Research paper	Mao et al., 2008, PLoS ONE 3(3): e1827 Modulation of Drosophila retinal epithelial integrity by the adhesion proteins capricious and tartan. [FBrf0210277] Sakurai et al., 2007, Dev. Biol. 309(1): 126--136 Differential control of cell affinity required for progression and refinement of cell boundary during Drosophila leg segmentation. [FBrf0201435] Krause et al., 2006, Dev. Biol. 296(1): 253--264 Distinct functions of the leucine-rich repeat transmembrane proteins Capricious and Tartan in the Drosophila tracheal morphogenesis. [FBrf0193895] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132] del Alamo Rodriguez et al., 2004, Dev. Biol. 268(2): 481--492 The role of the T-box gene optomotor-blind in patterning the Drosophila wing. [FBrf0174525] Janody et al., 2003, Development 130(16): 3691--3701 Two subunits of the Drosophila mediator complex act together to control cell affinity. [FBrf0160638] Abrell and Jackle, 2001, Mech. Dev. 109(1): 3--12 Axon guidance of Drosophila SNb motoneurons depends on the cooperative action of muscular Kruppel and neuronal capricious activities. [FBrf0139747] Milan et al., 2001, Cell 106(6): 785--794 The LRR proteins Capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing. [FBrf0139604] Abrell et al., 2000, Chromosoma 109(5): 334--342 A modifier screen of ectopic Kruppel activity identifies autosomal Drosophila chromosomal sites and genes required for normal eye development. [FBrf0129693] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Mlodzik and Hiromi, 1992, Conn, 1992: 397--414 Enhancer trap method in Drosophila: its application to neurobiology. [FBrf0066714]
Personal communication to FlyBase	Vosshall, 1998.8.10, Patterns of lacZ expression. Patterns of lacZ expression. [FBrf0103142] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]

Dmel\P{PZ}caps02937 Insertion

Dmel\P{PZ}caps⁰²⁹³⁷ Insertion