A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Dmel\P{PZ}fray07551 Insertion

General Information
Symbol Dmel\P{PZ}fray07551 Species D. melanogaster
Name FlyBase ID FBti0005585
Feature type transposable_element_insertion_site
Description
Inserted element P{PZ} Expression data lacZ reporter
Affected gene(s) CG7694, Ecol\lacZ, fray Viability / fertility
Causes allele(s) CG769407551, Ecol\lacZfray-07551, fray07551 Stock availability 1 publicly available
LINE ID l(3)07551
Genomic Location
Chromosomal location 3R ( 91B5 ) Sequence location 3R:14,411,351..14,411,351 [+]
Map ( GBrowse ) detailed view FBti0126153_2 FBti0126153_1 FBti0126154_1 FBti0126154_2 FBti0029717 FBti0145539 FBti0066911 FBti0112439 FBti0109942 FBti0028288 FBti0008030 FBti0102209 FBti0048097 FBti0126155_1 FBti0126155_2 FBti0005585 FBti0105539 FBti0105503 FBti0112517 FBti0053898 FBti0029635 FBti0028018 FBti0033446 FBti0044141 FBti0065230 FBti0065386 FBti0126156 FBti0106499 FBti0047398 FBti0043312 FBti0046294 FBti0052252 FBti0068222 FBti0049055 FBti0067378 FBti0066949 FBti0066520 FBti0056998 FBti0041695
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Description
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
Chromosome (arm)
Sequence Location
3R:14,411,351..14,411,351 [+]
Orientation
Cytological location
(computed by FlyBase)
91B5 ( inferred by FlyBase from sequence location )
Cytological location
(reported)
Comments concerning
location
hide Sequence Data
Flanking sequence
G00764
(FlyBase, 1992-,  
hide Inserted Element
Construct P{PZ}
Location-dependent
role
lacZ enhancer trap
(Mlodzik and Hiromi, 1992)
Size 14.545Kb
Associated alleles
Ecol\lacZP\T.PZ
l(3)87Df7.2
ry+t7.2
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
CG7694
(FlyBase, 1996-, Ryder and Roote, 2004.11.10)
Ecol\lacZ
(Russell et al., 1998, BDGP Project Members, 1994-1999, Vosshall, 1998.8.10)
fray
(BDGP Project Members, 1994-1999)
hide Alleles and Phenotypes
Causes alleles
CG769407551
(FlyBase, 1996-, Ryder and Roote, 2004.11.10)
Ecol\lacZfray-07551
(Russell et al., 1998, BDGP Project Members, 1994-1999, Vosshall, 1998.8.10)
fray07551
(BDGP Project Members, 1994-1999, Petitt, 1998.3.3, Leiserson et al., 2000, Maixner et al., 1998, Ryder and Roote, 2004.11.10, FlyBase, 1996-, Spradling et al., 1999, Russell et al., 1998)
Lethality
References
lethal | embryonic stage | maternal effect
(Perrimon et al., 1996)
lethal | larval stage | recessive
(Perrimon et al., 1996, Russell et al., 1998)
lethal | recessive
(Spradling et al., 1999)
Sterility
References
hide Phenotype Manifest In
embryonic/first instar larval cuticle
(Russell et al., 1998)
embryonic/first instar larval cuticle | maternal effect
(Perrimon et al., 1996)
embryonic/larval peripheral nervous system
(Leiserson et al., 2000)
hide Detailed Description
Statement
Reference
The segmental nerves exhibit a frayed nerve phenotype - localised bulging and swellings are seen i the nerve. Defects range from mild bulging to immense bulges that exceed 300μm in length and 50μm in diameter.
(Leiserson et al., 2000)
The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by fray07551.
(Maixner et al., 1998)
Homozygotes die during the second larval instar stage. Embryos derived from homozygous female germ line clones show poor cuticle development.
(Russell et al., 1998)
Germline clones produce eggs with poor cuticle development.
(Perrimon et al., 1996)
hide Expression Data
Reporter Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage  
adult brain | restricted  
(Vosshall, 1998.8.10)
adult central complex | restricted  
(Vosshall, 1998.8.10)
Additional Information
Statement
Reference
In the adult, low level of expression in discrete regions of the central brain.
(Vosshall, 1998.8.10)
In wandering third instar larva, no detectable β-gal staining.
(Meister and Braun, 1995.10)
Marker for
Reflects
expression of
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FlyView (LinkOut)
hide Data on Genetic Line
Line ID
l(3)07551
(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
11721
ry506 P{PZ}fray07551 CG769407551/TM3, ryRK Sb1 Ser1
hide Linkouts
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
P{PZ}fray07551
(FlyBase, 1992-)
P{PZ}l(3)0755107551
(BDGP Project Members, 1994-1999, FlyBase, 1992-)
P{ry+t7.2=PZ}l(3)0755107551
(FlyBase, 1992-)
PZ7551
(Leiserson et al., 2000)
Secondary FlyBase IDs
  • FBti0000639
hide References ( 15 )
Research paper
Bellen et al., 2004, Genetics 167(2): 761--781
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
Leiserson et al., 2000, Neuron 28(3): 793--806
Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment. [FBrf0132433]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Maixner et al., 1998, Dev. Genet. 23(4): 347--361
A screen for mutations that prevent lethality caused by expression of activated Sevenless and Ras1 in the Drosophila embryo. [FBrf0105879]
Russell et al., 1998, Genome 41(1): 7--13
Lethal P-lacZ insertion lines expressed during pattern respecification in the imaginal discs of Drosophila. [FBrf0102000]
Perrimon et al., 1996, Genetics 144(4): 1681--1692
Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. [FBrf0091142]
Mlodzik and Hiromi, 1992, Conn, 1992: 397--414
Enhancer trap method in Drosophila: its application to neurobiology. [FBrf0066714]
Personal communication to FlyBase
Ryder and Roote, 2004.11.10, DrosDel deletions confirmed by PCR and genetic tests.
DrosDel deletions confirmed by PCR and genetic tests. [FBrf0179888]
Petitt, 1998.3.3, Flybase entry for 'fray'.
Flybase entry for 'fray'. [FBrf0100825]
Vosshall, 1998.8.10, Patterns of lacZ expression.
Patterns of lacZ expression. [FBrf0103142]
Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington.
lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
FlyBase analysis
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
FlyBase inference based on genome sequence analysis. [FBrf0104946]
FlyBase, 1992-, FlyBase curation
FlyBase curation. [FBrf0105495]
Computer file
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0067338]