Dmel\P{lacW}lilli^k05431 Insertion

General Information
Symbol	Dmel\P{lacW}lilli^k05431	Species	D. melanogaster
Name		FlyBase ID	FBti0005897
Feature type	transposable_element_insertion_site
Description
Inserted element	P{lacW}	Expression data
Affected gene(s)	Ecol\lacZ, lilli	Viability / fertility
Causes allele(s)	Ecol\lacZ^lilli-k05431, lilli^k05431	Stock availability	2 publicly available
LINE ID	l(2)k05431
Genomic Location
Chromosomal location	2L ( 23C1-23C3 )	Sequence location
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	23C1-23C3 ( near gene of known cytology )
Cytological location (reported)	23C1-23C2 (in situ hybridization reported) (BDGP Project Members, 1994-1999)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{lacW}
Location-dependent role	lacZ enhancer trap (Bier et al., 1989)
Size	10.691Kb
Associated alleles	Ecol\lacZ^P\T.W w^+mC
Molecular map
Affected Gene(s)
Insertion may affect gene	Ecol\lacZ (BDGP Project Members, 1994-1999) lilli (BDGP Project Members, 1994-1999)
Alleles and Phenotypes
Causes alleles	Ecol\lacZ^lilli-k05431 (BDGP Project Members, 1994-1999) lilli^k05431 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Wittwer et al., 2001, Su et al., 2001, Kim-Ha et al., 1999)

Lethality References lethal \| recessive (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference run[Scer\UAS.cLa] (Scer\GAL4[nos.PG]) embryos that are also heterozygous for lilli[k05431] show a significant increase in viability from approximately 3% to approximately 35%. (Vanderzwan-Butler et al., 2007) Weak allele. Homozygous mutant cells in the eye compete successfully with heterozygous tissue in cell competition assays. (Wittwer et al., 2001)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID	l(2)k05431 (Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 2 )
Bloomington	10388 y¹ w^67c23; P{lacW}lilli^k05431/CyO
Kyoto	111080 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}lilli^k05431 P{neoFRT}40A/CyO y⁺
Linkouts
Comments
	This insertion was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was not verified as such prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Allan Spradling (spradling@mail1.ciwemb.edu). (FlyBase, 1992-)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{lacW}l(2)00632^k05431 (BDGP Project Members, 1994-1999, FlyBase, 1992-) P{lacW}lilli^k05431 (FlyBase, 1992-) P{lacW}SY2-1^k05431 (FlyBase, 1992-)
Secondary FlyBase IDs

References ( 10 )
Research paper	Vanderzwan-Butler et al., 2007, Dev. Biol. 301(2): 350--360 The HMG-box protein Lilliputian is required for Runt-dependent activation of the pair-rule gene fushi-tarazu. [FBrf0193025] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132] Su et al., 2001, Genetics 157(2): 717--725 A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's Lymphoma family of transcription factors in Drosophila melanogaster. [FBrf0132343] Wittwer et al., 2001, Development 128(5): 791--800 Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. [FBrf0134580] Kim-Ha et al., 1999, Molec. Cell. Biol. 19(4): 2505--2515 Requirement of RBP9, a Drosophila Hu homolog, for regulation of cystocyte differentiation and oocyte determination during oogenesis. [FBrf0107810] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Bier et al., 1989, Genes Dev. 3: 1273--1287 Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. [FBrf0049800]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]

Dmel\P{lacW}lillik05431 Insertion

Dmel\P{lacW}lilli^k05431 Insertion