A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Dmel\P{EP}p1130EP1130 Insertion

General Information
Symbol Dmel\P{EP}p1130EP1130 Species D. melanogaster
Name FlyBase ID FBti0007374
Feature type transposable_element_insertion_site
Description
Inserted element P{EP} Expression data
Affected gene(s) CG12643, p1130 Viability / fertility
Causes allele(s) p1130EP1130 Stock availability 1 publicly available
LINE ID EP(X)1130
Genomic Location
Chromosomal location X ( 9B5 ) Sequence location X:10,159,781..10,159,781 [+]
Map ( GBrowse ) detailed view FBti0019615 FBti0110770 FBti0035175 FBti0054376 FBti0027057 FBti0046564 FBti0021507 FBti0071702 FBti0051394 FBti0071565 FBti0007374
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
Chromosome (arm)
1
(BDGP Project Members, 1994-1999)
Sequence Location
X:10,159,781..10,159,781 [+]
(FlyBase, 2005)
Orientation
Cytological location
(computed by FlyBase)
9B5 ( inferred by FlyBase from sequence location )
Cytological location
(reported)
9B7-9B8 (in situ hybridization reported)
(BDGP Project Members, 1994-1999)
9B9-9B9 (reported as inferred from sequence location)
(BDGP Project Members, 2000-)
Comments concerning
location
hide Sequence Data
Flanking sequence
AQ025391
(FlyBase, 1992-,  
hide Inserted Element
Construct P{EP}
Location-dependent
role
mobile activating element (UASG)
(Rorth, 1996)
Size 7.987Kb
Associated alleles
Scer\UAS14x.hs
TrlBRcRa
w+mC
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
CG12643
(BDGP Project Members, 2000-)
p1130
(Liu et al., 2009)
hide Alleles and Phenotypes
Causes alleles
p1130EP1130
(Liu et al., 2009)
Lethality
References
Sterility
References
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
Mutant males and females show an increase in mean survival compared to control flies under the multiple-stress paradigm of 10mM paraquat and wet starvation. Mutant males and females show a mean lifespan enhancement of 38% and 22% respectively compared to control flies and a 15% maximum lifespan extension for both sexes. The mutant flies are longer lived than controls under both abundant and restricted food conditions. The mutant flies show no difference in food uptake or metabolic rate (as measured by carbon dioxide output) compared to controls. The mutant flies show a slight increased in fecundity and show enhanced climbing ability compared to controls.
(Liu et al., 2009)
p1130[EP1130]/α-Man-I[EP1628] and p1130[EP1130]/α-Man-I[EP982] flies have similar lifespan profiles as α-Man-I[EP982]/α-Man-I[EP1628] flies.
(Liu et al., 2009)
hide Expression Data
Reporter Expression
Additional Information
Statement
Reference
Marker for
Reflects
expression of
hide External Images
FlyView (LinkOut)
hide Data on Genetic Line
Line ID
EP(X)1130
(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
16988
w1118 P{EP}p1130EP1130
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hide Comments
Location X:10110968-10110969 determined by FlyBase alignment of dbGSS accession AQ025391 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation revised.
(FlyBase, 2005)
insertion of mobile activating element
(BDGP Project Members, 1994-1999)
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
EP1130
(Liu et al., 2009)
ep(x)1130
(FlyBase, 1992-)
EP(X)1130
(FlyBase, 1992-)
P{EP}EP1130
(FlyBase, 2005, FlyBase, 1992-)
P{EP}p1130EP1130
 
Secondary FlyBase IDs
hide References ( 9 )
Research paper
Liu et al., 2009, Aging Cell 8(4): 370--379
Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. [FBrf0208540]
Bellen et al., 2004, Genetics 167(2): 761--781
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Rorth, 1996, Proc. Natl. Acad. Sci. USA 93(22): 12418--12422
A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. [FBrf0090768]
FlyBase analysis
FlyBase, 2005, Assessment of transgenic construct insertion sites.
Assessment of transgenic construct insertion sites. [FBrf0184339]
FlyBase, 1992-, FlyBase curation
FlyBase curation. [FBrf0105495]
Computer file
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0125078]
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0067338]