A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Dmel\P{EP}DreddEP1412 Insertion

General Information
Symbol Dmel\P{EP}DreddEP1412 Species D. melanogaster
Name FlyBase ID FBti0007434
Feature type transposable_element_insertion_site
Description
Inserted element P{EP} Expression data
Affected gene(s) Dredd Viability / fertility
Causes allele(s) DreddEP1412 Stock availability 1 publicly available
LINE ID EP(X)1412
Genomic Location
Chromosomal location X ( 1B13 ) Sequence location X:529,528..529,528 [-]
Map ( GBrowse ) detailed view FBti0015641 FBti0039533 FBti0007434 FBti0024533 FBti0014706 FBti0014708 FBti0014702 FBti0014709 FBti0058824 FBti0014713 FBti0014705 FBti0014700 FBti0014701 FBti0014710 FBti0014715 FBti0014699 FBti0072030 FBti0014707 FBti0014712 FBti0014704 FBti0014703
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
Chromosome (arm)
1
(BDGP Project Members, 1994-1999)
Sequence Location
X:529,528..529,528 [-]
(BDGP Project Members, 2000-)
Orientation
Cytological location
(computed by FlyBase)
1B13 ( inferred by FlyBase from sequence location )
Cytological location
(reported)
1B7-1B7 (reported as inferred from sequence location)
(BDGP Project Members, 2000-)
1B12-1B14 (in situ hybridization reported)
(BDGP Project Members, 1994-1999)
Comments concerning
location
hide Sequence Data
Flanking sequence
AQ025449
(Benos et al., 2001, FlyBase, 1992-,  
hide Inserted Element
Construct P{EP}
Location-dependent
role
mobile activating element (UASG)
(Rorth, 1996)
Size 7.987Kb
Associated alleles
Scer\UAS14x.hs
TrlBRcRa
w+mC
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
Dredd
(BDGP Project Members, 2000-)
hide Alleles and Phenotypes
Causes alleles
DreddEP1412
(Elrod-Erickson et al., 2000, Di Fruscio et al., 2003, Leulier et al., 2000, Gene Disruption Project members, 2001-, Benos et al., 2001)
Lethality
References
Sterility
References
hide Phenotype Manifest In
macrochaeta | ectopic
(Ayyar et al., 2007)
mesothoracic tergum
(Ayyar et al., 2007)
hide Detailed Description
Statement
Reference
Heterozygotes show ectopic bristles in 12% of heminota at 18[o]C.
(Ayyar et al., 2007)
Dredd[EP1412]/+ Tollo[1]/+ double heterozygotes show ectopic bristles in 57% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes. Dredd[EP1412]/+ Rel[E20]/+ double heterozygotes show ectopic bristles in 58% of heminota at 18[o]C, a significant enhancement compared to the single heterozygotes.
(Ayyar et al., 2007)
Mutant adults are susceptible to infection by E.coli (infection by pricking with a needle dipped in a concentrated pellet of E.coli), showing reduced survival compared to controls.
(Sevrioukov et al., 2007)
Mutant animals have an increased susceptibility to E.coli infection. 30 and 40% of homozygous and heterozygous mutants survive respectively.
(Di Fruscio et al., 2003)
DreddEP1412/Df(1)su(s)R194 flies are immunocompromised.
(Elrod-Erickson et al., 2000)
hide Expression Data
Reporter Expression
Additional Information
Statement
Reference
Marker for
Reflects
expression of
hide External Images
FlyView (LinkOut)
hide Data on Genetic Line
Line ID
EP(X)1412
(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
10456
P{EP}DreddEP1412 w1118
hide Linkouts
hide Comments
Location X:492316-492317 confirmed by FlyBase alignment of dbGSS accession AQ025449 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation confirmed.
(FlyBase, 2005)
Maps to clone: 115C2
(Benos et al., 2001)
insertion of mobile activating element
(BDGP Project Members, 1994-1999)
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
EP1412
(Di Fruscio et al., 2003)
EP-1412
(Leulier et al., 2000)
ep(x)1412
(FlyBase, 1992-)
P{EP}DreddEP1412
(Benos et al., 2001, FlyBase, 2005, FlyBase, 1992-)
P{EP}EP1412
(FlyBase, 1992-)
Secondary FlyBase IDs
hide References ( 14 )
Research paper
Ayyar et al., 2007, PLoS ONE 2(11): e1178
NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. [FBrf0210269]
Sevrioukov et al., 2007, genesis 45(4): 184--193
Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development. [FBrf0202360]
Bellen et al., 2004, Genetics 167(2): 761--781
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
Di Fruscio et al., 2003, Proc. Natl. Acad. Sci. USA 100(4): 1814--1819
kep1 interacts genetically with dredd/Caspase-8, and kep1 mutants alter the balance of dredd isoforms. [FBrf0157185]
Benos et al., 2001, Genome Res. 11(5): 710--730
From First Base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. [FBrf0135823]
Elrod-Erickson et al., 2000, Curr. Biol. 10(13): 781--784
Interactions between the cellular and humoral immune responses in Drosophila. [FBrf0128454]
Leulier et al., 2000, EMBO Rpts 1(4): 353--358
The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. [FBrf0133276]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Rorth, 1996, Proc. Natl. Acad. Sci. USA 93(22): 12418--12422
A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. [FBrf0090768]
FlyBase analysis
FlyBase, 2005, Assessment of transgenic construct insertion sites.
Assessment of transgenic construct insertion sites. [FBrf0184339]
FlyBase, 1992-, FlyBase curation
FlyBase curation. [FBrf0105495]
Computer file
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0125078]
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0067338]