Dmel\P{A92}ana¹ Insertion

General Information
Symbol	Dmel\P{A92}ana¹	Species	D. melanogaster
Name		FlyBase ID	FBti0009048
Feature type	transposable_element_insertion_site
Description
Inserted element	P{A92}	Expression data
Affected gene(s)	ana, Ecol\lacZ	Viability / fertility
Causes allele(s)	ana¹, Ecol\lacZ^ana-1	Stock availability	2 publicly available
LINE ID
Genomic Location
Chromosomal location	2R ( 45A1 )	Sequence location	2R:4,963,451..4,963,874
Map ( GBrowse )
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location	2R:4,963,451..4,963,874 (Ebens et al., 1993)
Orientation
Cytological location (computed by FlyBase)	45A1 ( inferred by FlyBase from sequence location )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{A92}
Location-dependent role	lacZ enhancer trap (O'Kane and Gehring, 1987)
Size	12.127Kb
Associated alleles	Ecol\lacZ^P\T.A92 ry^+t7.2
Molecular map
Affected Gene(s)
Insertion may affect gene	ana (Ebens et al., 1993, Ebens et al., 1993) Ecol\lacZ (Park et al., 1997)
Alleles and Phenotypes
Causes alleles	ana¹ (Ebens et al., 1993, Park et al., 1997) Ecol\lacZ^ana-1 (Park et al., 1997)

Lethality References viable (Park et al., 1997)
Sterility References
Phenotype Manifest In
	neuroblast (Ebens et al., 1993)
Detailed Description
Statement Reference Homozygous adults have no gross morphological abnormalities. These adults do not live for long after eclosion under crowded conditions in competition with wild-type siblings. Homozygous ana¹ larvae show a reduced response to ethyl acetate in an olfactory assay compared to wild-type or ana¹; ana^+mEa larvae. (Park et al., 1997) Variable phenotype, ranging from subtle misrouting of fiber tracts to massive disorganization of the adult optic lobes. BrdU experiments reveal that optic lobe neuroblasts enter S phase earlier than in normal development. Early proliferation also occurs in central brain neuroblasts. Neuronal differentiation also occurred early. (Ebens et al., 1993) Rescued by P-elements carrying ana genomic and minigene constructs. (Ebens et al., 1993)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 2 )
Bloomington	8926 w^; P{A92}ana¹/CyO 8927 P{ana^+m}1, w^; P{A92}ana¹
Linkouts
Comments
	The P insertion falls within the final intron of ana. (Ebens et al., 1993)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{A92}ana¹ (FlyBase, 1992-) P{lacZ}ana¹ (FlyBase, 1992-, Ebens et al., 1993)
Secondary FlyBase IDs

References ( 4 )
Research paper	Park et al., 1997, J. Neurobiol. 33(2): 199--211 Mutation of the central nervous system neuroblast proliferation repressor ana leads to defects in larval olfactory behavior. [FBrf0096038] Ebens et al., 1993, Cell 74(1): 15--27 The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation. [FBrf0057907] O'Kane and Gehring, 1987, Proc. Natl. Acad. Sci. USA 84: 9123--9127 Detection in situ of genomic regulatory elements in Drosophila. [FBrf0047244]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]

Dmel\P{A92}ana1 Insertion

Dmel\P{A92}ana¹ Insertion