Dmel\P{PZ}dpr¹ Insertion

General Information
Symbol	Dmel\P{PZ}dpr¹	Species	D. melanogaster
Name		FlyBase ID	FBti0009786
Feature type	transposable_element_insertion_site
Description
Inserted element	P{PZ}	Expression data
Affected gene(s)	dpr, Ecol\lacZ	Viability / fertility
Causes allele(s)	dpr¹, Ecol\lacZ^dpr-1	Stock availability	1 publicly available
LINE ID
Genomic Location
Chromosomal location	2R ( 57B1-57B2 )	Sequence location
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	57B1-57B2 ( near gene of known cytology )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{PZ}
Location-dependent role	lacZ enhancer trap (Mlodzik and Hiromi, 1992)
Size	14.545Kb
Associated alleles	Ecol\lacZ^P\T.PZ l(3)87Df^7.2 ry^+t7.2
Molecular map
Affected Gene(s)
Insertion may affect gene	dpr (Nakamura et al., 2002) Ecol\lacZ (Hannaford and Palka, 1991, Nakamura et al., 2002)
Alleles and Phenotypes
Causes alleles	dpr¹ (Nakamura et al., 2002) Ecol\lacZ^dpr-1 (Hannaford and Palka, 1991, Nakamura et al., 2002)

Lethality References
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference Homozygous adults show a normal proboscis extension response (PER) in response to sucrose alone over a 10,000-fold range of sucrose concentrations. However, the PER in response to 0.1M sucrose in the presence of 1M NaCl is reduced only about 1.3-fold in dpr¹ flies, in contrast to wild type, where the PER is reduced 2.7- to 3-fold under these conditions. This indicates a defect in the salt aversion response. Homozygotes show a normal proboscis extension response (PER) to either glucose or fructose alone, but the suppression of the PER to glucose or fructose in the presence of 1M NaCl is reduced in homozygotes compared to controls. Heterozygotes have a normal salt aversion response. dpr¹/Df(2R)AA21 adults show a reduced salt-induced suppression of the proboscis extension response to 0.1M sucrose in the presence of 1M NaCl compared to wild-type adults. (Nakamura et al., 2002)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 1 )
Bloomington	25079 P{PZ}dpr¹; ry⁵⁰⁶
Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{lacZ}6705 (Hannaford and Palka, 1991, FlyBase, 1992-) P{PZ}dpr¹ (FlyBase, 1992-) PZ(2)6705 (Nakamura et al., 2002)
Secondary FlyBase IDs

References ( 4 )
Research paper	Nakamura et al., 2002, J. Neurosci. 22(9): 3463--3472 Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt. [FBrf0149073] Mlodzik and Hiromi, 1992, Conn, 1992: 397--414 Enhancer trap method in Drosophila: its application to neurobiology. [FBrf0066714]
Abstract	Hannaford and Palka, 1991, Greenspan, Palka, 1991: 59 A behavioral role for wing chemosensilla and identification of a new mutation affecting taste. [FBrf0078600]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]

Dmel\P{PZ}dpr1 Insertion

Dmel\P{PZ}dpr¹ Insertion