Dmel\P{lacW}ban^L1170a Insertion

General Information
Symbol	Dmel\P{lacW}ban^L1170a	Species	D. melanogaster
Name		FlyBase ID	FBti0009917
Feature type	transposable_element_insertion_site
Description
Inserted element	P{lacW}	Expression data
Affected gene(s)	ban, Ecol\lacZ	Viability / fertility
Causes allele(s)	ban^L1170a, Ecol\lacZ^ban-L1170a	Stock availability	2 publicly available
LINE ID	l(3)L1170
Genomic Location
Chromosomal location	3L ( 61C7 )	Sequence location	3L:639,743..639,743 [-]
Map ( GBrowse )
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location	3L:639,743..639,743 [-] (FlyBase, 2005)
Orientation
Cytological location (computed by FlyBase)	61C7 ( inferred by FlyBase from sequence location )
Cytological location (reported)	61C7-61C8 (in situ hybridization reported) (BDGP Project Members, 1994-1999)
Comments concerning location
Sequence Data
Flanking sequence	AQ026239
Inserted Element
Construct	P{lacW}
Location-dependent role	lacZ enhancer trap (Bier et al., 1989)
Size	10.691Kb
Associated alleles	Ecol\lacZ^P\T.W w^+mC
Molecular map
Affected Gene(s)
Insertion may affect gene	ban (BDGP Project Members, 1994-1999) Ecol\lacZ (BDGP Project Members, 1994-1999)
Alleles and Phenotypes
Causes alleles	ban^L1170a (Hipfner et al., 2002, Brennecke et al., 2003) Ecol\lacZ^ban-L1170a (BDGP Project Members, 1994-1999)

Lethality References viable (Hipfner et al., 2002)
Sterility References female sterile (Hipfner et al., 2002)
Phenotype Manifest In

Detailed Description
Statement Reference ban[L1170a] homozygotes or ban[L1170a]/Df(3L)ban[Δ1] hemizygotes survive to adulthood and show wild-type levels of apoptosis. Imaginal discs in ban[L1170a] homo- and hemizygotes or ban[EP3622]/ban[L1170a] transheterozygotes show significantly higher levels of AO staining than wild-type, indicating that these mutants undergo IR-induced apoptosis more readily than wild-type. (Jaklevic et al., 2008) EP3219^EP3219 combined with ban^L1170a has little or no effect on growth. (Hipfner et al., 2002) The body mass of ban^L1170a/Df(3L)ban^Δ1 adults is only 85% of that of control flies. The wing blade area of ban^L1170a/Df(3L)ban^Δ1 flies is only 87% of that of controls. This decrease is entirely due to a decrease in the number of cells, and is not due to a decrease in cell size. (Hipfner et al., 2002)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID	l(3)L1170 (Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 2 )
Bloomington	10154 y¹ w¹¹¹⁸; P{lacW}ban^L1170a, l(3)L1170b^L1170b/TM3, Ser¹
Kyoto	111004 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}ban^L1170a P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹
Linkouts
Comments
	Location 3L:623274-623275 determined by FlyBase alignment of dbGSS accession AQ026239 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation revised. (FlyBase, 2005) Separable from l(3)L1170b^L1170b. (BDGP Project Members, 1994-1999)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{lacW}ban^L1170a (FlyBase, 2005, BDGP Project Members, 1994-1999, FlyBase, 1992-) P{lacW}l(3)L1170^L1170 (BDGP Project Members, 1994-1999, FlyBase, 1992-)
Secondary FlyBase IDs

References ( 11 )
Research paper	Jaklevic et al., 2008, Dev. Biol. 320(1): 122--130 Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. [FBrf0207139] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132] Brennecke et al., 2003, Cell 113(1): 25--36 bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. [FBrf0158764] Hipfner et al., 2002, Genetics 161(4): 1527--1537 The bantam gene regulates Drosophila growth. [FBrf0152024] LaJeunesse et al., 2001, Genetics 158(2): 667--679 A Systematic screen for dominant second-site modifiers of Merlin/NF2 Phenotypes reveals an interaction with blistered/DSRF and scribbler. [FBrf0136951] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Bier et al., 1989, Genes Dev. 3: 1273--1287 Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. [FBrf0049800]
FlyBase analysis	FlyBase, 2005, Assessment of transgenic construct insertion sites. Assessment of transgenic construct insertion sites. [FBrf0184339] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]

Dmel\P{lacW}banL1170a Insertion

Dmel\P{lacW}ban^L1170a Insertion