Dmel\P{PZ}ttk¹ Insertion

General Information
Symbol	Dmel\P{PZ}ttk¹	Species	D. melanogaster
Name		FlyBase ID	FBti0010334
Feature type	transposable_element_insertion_site	Created / Updated	1998-06-19/1998-07-29
Description
Inserted element	P{PZ}	Localized function
Affected gene(s)	ttk	Expression data
Causes allele(s)	ttk¹	Viability / fertility
LINE ID		Stock availability
Genomic Location
Chromosomal location	3R ( 100D1 )	Sequence location	3R:27,555,354..27,558,117 [+]
Map ( GBrowse )
Detailed Mapping Data
Chromosome (arm)
Sequence Location	3R:27,555,354..27,558,117 [+] (Giesen et al., 1997, Xiong and Montell, 1993)
Orientation
Cytological location (computed by FlyBase)	100D1 ( inferred by FlyBase from sequence location )
Cytological location (reported)
Chromosome in situ
Sequence Data
Flanking sequence
Inserted Element
Construct	P{PZ}
Location-dependent role
Size	14.545Kb
Associated alleles	ry^+t7.2 Ecol\lacZ^P\T.PZ l(3)87Df^7.2
Molecular map
Transposon class
Element type
Affected Gene(s)
Insertion within gene
Insertion may affect gene	ttk (Xiong and Montell, 1993, Giesen et al., 1997)
Orientation (relative to gene)	Gene Orientation References
Alleles and Phenotypes
Causes alleles	ttk¹ (Xiong and Montell, 1993, Giesen et al., 1997, Serrano et al., 1995, Lai et al., 1996, Okabe et al., 2001)

Lethality References viable (Lai et al., 1996)
Sterility References
Phenotype Manifest In
	dorsal appendage \| maternal effect (French et al., 2003) rhabdomere R1 (Xiong and Montell, 1993) rhabdomere R2 (Xiong and Montell, 1993) rhabdomere R3 (Xiong and Montell, 1993) rhabdomere R4 (Xiong and Montell, 1993) rhabdomere R5 (Xiong and Montell, 1993) rhabdomere R6 (Xiong and Montell, 1993) rhabdomere R7 (Xiong and Montell, 1993) rhabdomere R8 (Xiong and Montell, 1993) photoreceptor cell R7 (Lai et al., 1996) trichogen cell \| supernumerary (Okabe et al., 2001) external sensory organ (Okabe et al., 2001)
Detailed Description
Statement Reference In sev⁶ hemizygotes that are also heterozygous for Sos^JC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly suppressed by ttk¹. (Dong et al., 1999) The addition of or ttk¹/+ to h⁴¹/+ animals does not lead to a significant ectopic wing margin bristle phenotype. (Badenhorst et al., 2002) The partial lethality due to run^Scer\UAS.cLa; Scer\GAL4^nos.PG (3% viable) is partially suppressed by maternal heterozygosity for ttk¹ (rescues to 19% viable). (Wheeler et al., 2002) embryonic lethal no effect on ftz gene expression. Many ommatidia contain supernumerary R7 cells and decreased numbers of R1-R6 cells. (Xiong and Montell, 1993) The compound eye of ttk^bose1/ttk¹ flies is similar to wild-type. (Yamamoto et al., 1996) Rough eye phenotype due to supernumerary R7 cells. Mutant phenotype can be enhanced by ttk⁰⁰²¹⁹. (Lai et al., 1996) CNS development is normal. (Giesen et al., 1997) Shows a semidominant double bristle phenotype - similar to that caused by overexpression of the TTK69 isoform. (Okabe et al., 2001) Eggs laid by ttk^twp/ttk¹ or homozygous ttk¹ mothers exhibit a weak dorsal appendage phenotype, with 12% show some defect. Only 40% of eggs laid by ttk¹/ttk^1e11 mothers are wild-type,, the rest exhibit a dorsal appendage phenotype, 3% having only the nub of an appendage. (French et al., 2003) 94% of the ommatidia in ttk¹/ttk^1e11 flies were wild-type, as opposed to 50-60% in ttk¹ homozygotes. There are 65% of normal ommatidia in ttk¹/ttk^rM730 flies and most mutant ommatidia contain ectopic photoreceptors. (Lai and Li, 1999)
Expression Data
Reporter Expression
Stage Tissue/Position Reference
Additional Information
Statement Reference

Assay mode
Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Comments
	Mutation is an insertion of a p[lacZ,rosy] element. Position of insertion on reference sequence inferred by FlyBase curator based on author statement. See Figure 2 of FBrf0094782. (Giesen et al., 1997, Xiong and Montell, 1993)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{lacZ}ttk¹ (Giesen et al., 1997, FlyBase, 1992-) P{PZ}ttk¹ (FlyBase, 1992-, Giesen et al., 1997, Xiong and Montell, 1993)
Secondary FlyBase IDs
	FBti0009110
References ( 14 )
Research paper	French et al., 2003, Dev. Biol. 253(1): 18--35 The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis. [FBrf0155483] Badenhorst et al., 2002, Mech. Dev. 117(1-2): 87--101 Tramtrack co-operates to prevent inappropriate neural development in Drosophila. [FBrf0152198] Wheeler et al., 2002, Nature Genetics 32(1): 206--210 Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. [FBrf0152256] Okabe et al., 2001, Nature 411(6833): 94--98 Translational repression determines a neuronal potential in Drosophila asymmetric cell division. [FBrf0135902] Dong et al., 1999, Genes Dev. 13(8): 954--965 ebi regulates epidermal growth factor receptor signaling pathways in Drosophila. [FBrf0108171] Lai and Li, 1999, Genetics 152(1): 299--305 Tramtrack69 is positively and autonomously required for Drosophila photoreceptor development. [FBrf0108223] Giesen et al., 1997, Development 124(12): 2307--2316 Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes. [FBrf0094782] Lai et al., 1996, Proc. Natl. Acad. Sci. USA 93(10): 5025--5030 Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background. [FBrf0087523] Yamamoto et al., 1996, Roux Arch. dev. Biol. 205(5-6): 215--224 Genetic interactions of pokkuri with seven in absentia, tramtrack and downstream components of the sevenless pathway in R7 photoreceptor induction in Drosophila melanogaster. [FBrf0086690] Serrano et al., 1995, Development 121(6): 1691--1703 polyhomeotic appears to be a target of engrailed regulation in Drosophila. [FBrf0079388] Xiong and Montell, 1993, Genes Dev. 7(6): 1085--1096 tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye. [FBrf0058514] Read and Manley, 1992, EMBO J. 11: 1035--1044 Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. [FBrf0055940] Harrison and Travers, 1990, EMBO J. 9(6): 207--216 The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern. [FBrf0051631]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]

Dmel\P{PZ}ttk1 Insertion

Dmel\P{PZ}ttk¹ Insertion