Dmel\P{EP}Fas2^EP1462 Insertion

General Information
Symbol	Dmel\P{EP}Fas2^EP1462	Species	D. melanogaster
Name		FlyBase ID	FBti0011908
Feature type	transposable_element_insertion_site
Description
Inserted element	P{EP}	Expression data
Affected gene(s)	Fas2	Viability / fertility
Causes allele(s)	Fas2^EP1462	Stock availability	1 publicly available
LINE ID	EP(X)1462
Genomic Location
Chromosomal location	X ( 4B3 )	Sequence location	X:4,100,162..4,100,162 [-]
Map ( GBrowse )
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location	X:4,100,162..4,100,162 [-] (FlyBase, 2005)
Orientation
Cytological location (computed by FlyBase)	4B3 ( inferred by FlyBase from sequence location )
Cytological location (reported)	4B1-4B2 (in situ hybridization reported) (BDGP Project Members, 1994-1999) 4B3-4B3 (reported as inferred from sequence location) (BDGP Project Members, 2000-)
Comments concerning location
Sequence Data
Flanking sequence	AQ254776 (FlyBase, 1992-)
Inserted Element
Construct	P{EP}
Location-dependent role	mobile activating element (UASG) (Rorth, 1996)
Size	7.987Kb
Associated alleles	Scer\UAS^14x.hs TrlBR^cRa w^+mC
Molecular map
Affected Gene(s)
Insertion may affect gene	Fas2 (BDGP Project Members, 2000-, Buff et al., 2007)
Alleles and Phenotypes
Causes alleles	Fas2^EP1462 (Kraut et al., 2001, Gene Disruption Project members, 2001-, Kraut et al., 2001, Pascual et al., 2005, Buff et al., 2007)

Lethality References
Sterility References
Phenotype Manifest In
	anterior fascicle & synapse (Kraut et al., 2001) anterior fascicle & synapse \| supernumerary (Kraut et al., 2001) intersegmental nerve (Kraut et al., 2001)
Detailed Description
Statement Reference Mutant larvae expressing Fas2^EP1462 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects. Mutant larvae expressing Fas2^EP1462 under the control of Scer\GAL4^elav-C155 have excessive or ectopic synapses. Mutant larvae expressing Fas2^EP1462 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. (Kraut et al., 2001)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID	EP(X)1462 (Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 1 )
Bloomington	11231 w¹¹¹⁸ P{EP}Fas2^EP1462
Linkouts
Comments
	Location X:4051365-4051366 determined by FlyBase alignment of dbGSS accession AQ254776 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation revised. (FlyBase, 2005) insertion of mobile activating element (BDGP Project Members, 1994-1999)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	EP(X)1462 (Kraut et al., 2001, Kraut et al., 2001, FlyBase, 1992-, Buff et al., 2007) P{EP}EP1462 (FlyBase, 1992-) P{EP}Fas2^EP1462 (FlyBase, 2005, FlyBase, 1992-)
Secondary FlyBase IDs

References ( 13 )
Research paper	Buff et al., 2007, Genetics 176(1): 209--220 Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration. [FBrf0201672] Pascual et al., 2005, Nucleic Acids Res. 33(1): e7 Conditional UAS-targeted repression in Drosophila. [FBrf0184225] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132] Marcus, 2003, Genetics 163(2): 591--597 Female site-specific transposase-induced recombination: a high-efficiency method for fine mapping mutations on the X chromosome in Drosophila. [FBrf0157240] Kraut et al., 2001, Curr. Biol. 11(6): 417--430 A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. [FBrf0135708] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Rorth, 1996, Proc. Natl. Acad. Sci. USA 93(22): 12418--12422 A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. [FBrf0090768]
Supplementary material	Kraut et al., 2001, Curr. Biol. 11(6): A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. [FBrf0135968]
FlyBase analysis	FlyBase, 2005, Assessment of transgenic construct insertion sites. Assessment of transgenic construct insertion sites. [FBrf0184339] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]

Dmel\P{EP}Fas2EP1462 Insertion

Dmel\P{EP}Fas2^EP1462 Insertion