Dmel\P{lacW}srpk79D^P1 Insertion

General Information
Symbol	Dmel\P{lacW}srpk79D^P1	Species	D. melanogaster
Name		FlyBase ID	FBti0012228
Feature type	transposable_element_insertion_site
Description
Inserted element	P{lacW}	Expression data
Affected gene(s)	Csp, srpk79D	Viability / fertility
Causes allele(s)	srpk79D^P1	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	3L ( 79D4 )	Sequence location	3L:22,268,457..22,268,457 [+]
Map ( GBrowse )
Member of Large Scale Dataset(s)
Dataset
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location	3L:22,268,457..22,268,457 [+] (Eberle et al., 1998)
Orientation
Cytological location (computed by FlyBase)	79D4 ( inferred by FlyBase from sequence location )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{lacW}
Location-dependent role	lacZ enhancer trap (Bier et al., 1989)
Size	10.691Kb
Associated alleles	Ecol\lacZ^P\T.W w^+mC
Molecular map
Affected Gene(s)
Insertion may affect gene	Csp (Eberle et al., 1998, Eberle et al., 1998) srpk79D (Nieratschker et al., 2009)
Alleles and Phenotypes
Causes alleles	srpk79D^P1 (Eberle et al., 1998, Nieratschker et al., 2009)

Lethality References
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference The impaired flight, impaired walking and reduced longevity of srpk79D[P1] mutants are fully or partially rescued by transgenic pan-neural expression of srpk79D[RF.Scer\UAS.cNa] driven by Scer\GAL4[elav-C155]. (Nieratschker et al., 2009) General axonal transport and basic synaptic structure appear intact in srpk79D[P1] mutants. srpk79D[P1] mutant flies display flight impairment, reduced ability or motivation to walk on a horizontal surface, as well as reduced life span. (Nieratschker et al., 2009) Shows no reconizable mutant phenotype. (Eberle et al., 1998)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Comments
	The P insertion is in a negative orientation with repect to Csp gene transcription. (Eberle et al., 1998)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{lacW}Csp^P2 (Nieratschker et al., 2009, FlyBase, 1992-, Eberle et al., 1998) P{lacW}srpk79D^P1 P{lacW}Srpk79D^P1 (Nieratschker et al., 2009)
Secondary FlyBase IDs

References ( 4 )
Research paper	Nieratschker et al., 2009, PLoS Genet. 5(10): e1000700 Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila. [FBrf0208928] Eberle et al., 1998, Cell Tissue Res. 294(2): 203--217 Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis. [FBrf0104892] Bier et al., 1989, Genes Dev. 3: 1273--1287 Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. [FBrf0049800]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Dmel\P{lacW}srpk79DP1 Insertion

Dmel\P{lacW}srpk79D^P1 Insertion