Dmel\P{if-lacZ.L}eg^T6 Insertion

General Information
Symbol	Dmel\P{if-lacZ.L}eg^T6	Species	D. melanogaster
Name		FlyBase ID	FBti0013363
Feature type	transposable_element_insertion_site
Description
Inserted element	P{if-lacZ.L}	Expression data
Affected gene(s)	eg	Viability / fertility
Causes allele(s)	eg^T6	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	3L ( 78F2-78F3 )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	78F2-78F3 ( near gene of known cytology )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{if-lacZ.L}
Location-dependent role
Size
Associated alleles	Ecol\lacZ^if.PL
Molecular map
Affected Gene(s)
Insertion may affect gene	eg (Urban et al., 1993)
Alleles and Phenotypes
Causes alleles	eg^T6 (Urban et al., 1993, Lundell and Hirsh, 1998)

Lethality References lethal \| pupal stage \| recessive (Lundell and Hirsh, 1998)
Sterility References
Phenotype Manifest In
	EW1 neuron (Lundell and Hirsh, 1998) serotonergic neuron (Lundell and Hirsh, 1998) ventral nerve cord & serotonin neuron (Lundell and Hirsh, 1998)
Detailed Description
Statement Reference Many hemisegments show severe reduction in the number of serotonin neuron: mutants exhibit a single cell instead of the normal mitotic pair in thoracic and abdominal segments. The serotonin cells can synthesise serotonin but have other abnormal properties: abnormal axonal projections. nub and zfh2 staining reveals the more medial serotonin cell of the mitotic pair is lost: the EW1 neuron. 15% pupae survive to become viable adults, adults exhibit reduced number of serotonin neurons in the ventral cord. Both larvae and flies appear normal for phototaxis and geotaxis. The adults are much less active in locomotion. Flight is impossible due to the extended wings. Adults also have difficulty holding onto glass surfaces when climbing vertically or when rotated upside down, flies have no obvious morphological defects in the legs or tarsi. (Lundell and Hirsh, 1998)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{if-lacZ.L}eg^T6 (Urban et al., 1993, FlyBase, 1992-)
Secondary FlyBase IDs

References ( 3 )
Research paper	Lundell and Hirsh, 1998, Development 125(3): 463--472 eagle is required for the specification of serotonin neurons and other neuroblast 7-3 progeny in the Drosophila CNS. [FBrf0100717]
Abstract	Urban et al., 1993, Europ. Dros. Res. Conf. 13: PosterD8 A putative homeotic target gene that is expressed in specific neuronal and glial precursor cells in the embryonic CNS of Drosophila. [FBrf0058413]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Dmel\P{if-lacZ.L}egT6 Insertion

Dmel\P{if-lacZ.L}eg^T6 Insertion