Dmel\P{}RpS6^air8 Insertion

General Information
Symbol	Dmel\P{}RpS6^air8	Species	D. melanogaster
Name		FlyBase ID	FBti0014201
Feature type	transposable_element_insertion_site
Description
Inserted element	P-element	Expression data
Affected gene(s)	RpS6	Viability / fertility
Causes allele(s)	RpS6^air8	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	X ( 7C2 )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
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FB2013_03
FB2013_02
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Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	7C2 ( near gene of known cytology )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P-element
Location-dependent role
Size
Associated alleles
Molecular map
Affected Gene(s)
Insertion may affect gene	RpS6 (Watson et al., 1991)
Alleles and Phenotypes
Causes alleles	RpS6^air8 (Watson et al., 1992, Watson et al., 1991)

Lethality References lethal (Watson and Bryant, 1991) lethal \| larval stage \| recessive (Watson et al., 1991, Watson et al., 1992)
Sterility References
Phenotype Manifest In
	embryonic/larval lymph gland (Watson and Bryant, 1991)
Detailed Description
Statement Reference Embryonic and larval development retarded, ring gland, salivary glands, gastric cecae and most imaginal discs fail to reach normal size before late larval lethal phase. Ventral ganglion fails to condense and the brain hemispheres are undersized, and at death, large melanotic tumours resulting from abnormalities in hematopoiesis are present in the body cavity. Source of the hemocytes is a hyperplastic lymph gland, which contain lamellocytes (normally not found in lymph gland) in process of abnormal self encapsulation. (Watson et al., 1992) Melanotic tumour formation and lethality are due to the same mutation. Mutations exhibit incomplete penetrance and expressivity of the melanotic tumour phenotype. Small and/or abnormally shaped brain. Garland cells found at the junction of the oesophagus and proventriculus are melanized. Hemizygous males exhibit hypertrophied lymph glands. (Watson et al., 1991) Neoplastic growth and melanotic encapsulation of the lymph glands. Transplanted lymph glands cause melanotic tumour formation and premature host death. (Watson and Bryant, 1991)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{}RpS6^air8 (Watson et al., 1991, FlyBase, 1992-)
Secondary FlyBase IDs

References ( 4 )
Research paper	Watson et al., 1992, Proc. Natl. Acad. Sci. U.S.A. 89: 11302--11306 Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. [FBrf0057504] Watson et al., 1991, Dev. Genet. 12: 173--187 Lethal(1) aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster. [FBrf0053739]
Abstract	Watson and Bryant, 1991, A. Dros. Res. Conf. 32: 68 air8, a new tumor-suppressor gene affecting blood-forming organs. [FBrf0066331]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Dmel\P{}RpS6air8 Insertion

Dmel\P{}RpS6^air8 Insertion