Dmel\412{}bw¹ Insertion

General Information
Symbol	Dmel\412{}bw¹	Species	D. melanogaster
Name		FlyBase ID	FBti0014269
Feature type	transposable_element
Description
Inserted element	412	Expression data
Affected gene(s)	bw	Viability / fertility
Causes allele(s)	bw¹	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	2R ( 59E2-59E3 )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	59E2-59E3 ( near gene of known cytology )
Cytological location (reported)	59E2-59E3 (reported as inferred from sequence location) (Quesneville et al., 2005.6.22) 59E2-59E3 (reported as inferred from sequence location) (Kaminker et al., 2002)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	412
Location-dependent role
Size
Associated alleles
Molecular map
Affected Gene(s)
Insertion may affect gene	bw (Dreesen et al., 1988)
Alleles and Phenotypes
Causes alleles	bw¹ (Dreesen et al., 1988, FlyBase Genome Annotators, 2002-2003)

Lethality References
Sterility References
Phenotype Manifest In
	pigment cell
Detailed Description
Statement Reference Sound-evoked compound action potentials in the antennal nerve are not significantly different from wild type in mutant flies. However, nonlinear mechanical amplification is significantly increased compared to wild type. (Senthilan et al., 2012) The glycerol hypersensitivity of flies expressing Gyk[dsRNA.Scer\UAS] under the control of Scer\GAL4[c564] (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for bw[1]. (Wightman et al., 2012) Mutant flies have significantly fewer synaptic vesicles in the terminals of the photoreceptor cells R1-R6 in the lamina. However, in contrast to the absolute numbers of synaptic vesicles, the profile density is not significantly different from wild type. (Borycz et al., 2008) The increased resistance of bw¹ homozygous males to enflurane is not enhanced or suppressed by st¹/st¹. bw¹/+, st¹/+ males from bw¹, st¹ homozygous mothers show increased resistance to halothane when tested under red light and a slight increase in this resistance when tested under white light. A maternal effect is necessary for this phenotype as it is not seen in bw¹/+, st¹/+ males from bw¹, st¹ homozygous fathers. (Campbell and Nash, 2001) Male heterozygous and homozygous bw¹ flies have an increased resistance to the anesthetic enflurane compared to wild-type controls, as judged by climbing ability. This effect is true whether enflurane resistance is measured in regular light or red light. bw¹ male flies show no increased resistance to the anesthetic halothane compared to wild-type flies when climbing ability is measured in regular light. However, bw¹ mutants show increased sensitivity to this anesthetic when climbing ability is measured in red light. (Campbell and Nash, 2001) Eye colour: off-white, with In(2LR)Nella. (Henikoff et al., 1995) Affects the formation of drosopterins and reduces level of ommochrome in the eye. (Tearle, 1991) Red pigments lacking. Xanthommatin mostly replaced by dihydroxanthommatin. Pigment granules present but somewhat smaller than in wild type. (Phillips et al., 1973) Malpighian tubule colour: pale yellow. Testes colour: colourless. (Beadle, 1937) Eye colour: brown. Eye colour: light brownish wine on emergence, darkening to garnet. Eye colour: white, with cn¹. Eye colour: white, with st¹. Eye colour: white, with v¹.
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	412{}878 (FlyBase Genome Annotators, 2002-2003, Kaminker et al., 2002, FlyBase, 1992-) 412{}bw¹ (FlyBase, 1992-) ?{}bw¹ (Dreesen et al., 1988, FlyBase, 1992-) TE18870 (FlyBase Genome Annotators, 2002-2003, FlyBase, 1992-)
Secondary FlyBase IDs
	FBti0018870
References ( 14 )
Research paper	Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Wightman et al., 2012, PLoS ONE 7(3): e31779 Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes. [FBrf0217823] Borycz et al., 2008, J. Exp. Biol. 211(21): 3454--3466 Drosophila ABC transporter mutants white, brown and scarlet have altered contents and distribution of biogenic amines in the brain. [FBrf0206178] Quesneville et al., 2005, PLoS Comput. Biol. 1(2): e22 Combined evidence annotation of transposable elements in genome sequences. [FBrf0186342] Kaminker et al., 2002, Genome Biol. 3(12): RESEARCH0084 The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective. [FBrf0155828] Campbell and Nash, 2001, J. Neurobiol. 49(4): 339--349 Volatile general anesthetics reveal a neurobiological role for the white and brown genes of Drosophila melanogaster. [FBrf0141614] Henikoff et al., 1995, Genetics 140(3): 1007--1017 Distance and pairing effects on the brown^Dominant heterochromatic element in Drosophila. [FBrf0083184] Tearle, 1991, Genet. Res. (Camb.) 57: 257--266 Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster. [FBrf0054090] Dreesen et al., 1988, Mol. Cell. Biol. 8: 5206--5215 The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes. [FBrf0048677] Phillips et al., 1973, Genetics 73(1): 45--56 Terminal synthesis of xanthommatin in Drosophila melanogaster. [FBrf0025065] Beadle, 1937, Genetics 22: 587--611 Development of eye colors in Drosophila: fat bodies and Malpighian tubes as sources of diffusible substances. [FBrf0003911]
Personal communication to FlyBase	Quesneville et al., 2005.6.22, r4 TE data. r4 TE data. [FBrf0184336]
FlyBase analysis	FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Dmel\412{}bw1 Insertion

Dmel\412{}bw¹ Insertion