Dmel\gypsy{}h¹ Insertion

General Information
Symbol	Dmel\gypsy{}h¹	Species	D. melanogaster
Name		FlyBase ID	FBti0014476
Feature type	transposable_element_insertion_site	Created / Updated	2000-01-06/2000-01-06
Description
Inserted element	gypsy	Localized function
Affected gene(s)	h	Expression data
Causes allele(s)	h¹	Viability / fertility
LINE ID		Stock availability
Genomic Location
Chromosomal location	3L ( 66D10 )	Sequence location
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	66D10 ( near gene of known cytology )
Cytological location (reported)
Chromosome in situ
Sequence Data
Flanking sequence
Inserted Element
Construct	gypsy
Location-dependent role
Size
Associated alleles
Molecular map
Transposon class
Element type
Affected Gene(s)
Insertion within gene
Insertion may affect gene	h (Hooper et al., 1989)
Orientation (relative to gene)	Gene Orientation References
Alleles and Phenotypes
Causes alleles	h¹ (Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989)

Lethality References viable (Ingham et al., 1985, Abu-Issa and Cavicchi, 1996, Tearle and Nusslein-Volhard, 1987, Zeng et al., 2000, Hooper et al., 1989)
Sterility References
Phenotype Manifest In
	scutellum & macrochaeta (Ingham et al., 1985) haltere & macrochaeta (Ingham et al., 1985) head capsule & macrochaeta (Ingham et al., 1985) macrochaeta \| ectopic (Ingham et al., 1985, Rushlow et al., 1989) larval abdominal segment 4 (Ingham et al., 1985) adult abdominal segment 4 (Ingham et al., 1985) neuron (Sturtevant and Bier, 1995) wing sensillum \| ectopic (Abu-Issa and Cavicchi, 1996) wing (Abu-Issa and Cavicchi, 1996, Giangrande, 1995) wing vein L2 & macrochaeta & adult (Rushlow et al., 1989) microchaeta & mesothoracic tergum \| supernumerary (Renaud and Simpson, 2002) microchaeta \| ectopic & scutellum (Villa-Cuesta et al., 2003) medial triple row (Dominguez and Campuzano, 1993) wing margin bristle (Dominguez and Campuzano, 1993) wing hair (Dominguez and Campuzano, 1993) wing hair & wing vein L2 (Dominguez and Campuzano, 1993) dorsal triple row (Dominguez and Campuzano, 1993) chemosensory ventral triple row (Dominguez and Campuzano, 1993) wing & neuron & glial cell (Giangrande, 1995) neuron \| ectopic (Giangrande, 1995) glial cell \| ectopic (Giangrande, 1995) wing vein (Giangrande, 1995) wing vein \| ectopic (Giangrande, 1995) wing vein & wing sensillum \| ectopic \| somatic clone (Zeng et al., 2000) adult thorax & microchaeta \| ectopic \| somatic clone (Zeng et al., 2000) mesothoracic tergum & macrochaeta \| ectopic \| conditional cs (Gibert et al., 2005)
Detailed Description
Statement Reference Df(1)ase-1; h¹ double mutants have four-fold fewer bristles in the L2 vein than h¹ mutants alone. Although h¹ has no effect on the anterior wing margin bristles itself, the recurved bristles of Df(1)ase-1; h¹ double mutants are more wild type than those of Df(1)ase-1, though the mutant phenotype of the stout mechanosensory bristles is more extreme. (Dominguez and Campuzano, 1993) Introduction of ac^T52.2 construct into an ac^- sc^- h^- background causes ectopic bristles to appear along wing vein L5. (van Doren et al., 1994) h¹ rho^ve-1 / h¹ rho^ve-1 flies have ectopic bristles running between longitudinal veins. (Biehs et al., 1998) h¹/h^- is viable, whereas nkd^unspecified h¹/h^- is lethal. nkd³ h¹ or nkd⁴ h¹ clones give rise to a rough eye phenotype and loss of wing margin bristles. (Zeng et al., 2000) The ectopic microchaetae seen on the scutellum in h¹ flies are suppressed by amos^Tft. (Villa-Cuesta et al., 2003) pad¹ h¹ double mutants raised at 25^oC display ectopic bristles at positions on the notum where no ectopic bristles are found in either single mutant. These new positions include dorso-central bristles closer to the thoracic midline and additional bristles between the anterior and posterior scutellars. Ectopic bristles on the double mutant are mostly located in the posterior half of the notum, while ectopic bristles tend to be found in the anterior half in pad¹ single mutants. (Gibert et al., 2005) viable 70% of homozygotes survive to adulthood. Homozygous adults have extra bristles. Homozygotes have minor defects in segmentation, that are apparent both in the larva and the adult; a few segments are wholly or partially deleted. The fourth abdominal segment is most frequently affected, although other segments in the head, thorax or abdomen may also be affected. The frequency and severity of the segmentation phenotype is increased in trans with other lethal h alleles. h¹/h⁴¹ flies have ectopic bristles on the scutellum, halteres and head capsule. (Ingham et al., 1985) Semilethal when heterozygous with strong h alleles. (Hooper et al., 1989) Homozygotes display ectopic bristles on the L2 wing vein. (Rushlow et al., 1989) Extra sense organs formed on wing surface. Campaniform sensillae preferentially form on the proximal end of the L3 vein, bristles form nearer the tip, and sense organs of intermediate size form in between the bristles and campaniform sensillae. Scanning electron microscope measurements of distribution of sense organs along the wing axis suggests that h is active in metamorphosis and has a pattern of expression that is dependent upon the position in the proximal-distal axis. (Thompson and Preston, 1992) Ectopic glia accompany ectopic nerves in the pupal wing, which occur mostly along the longitudinal wing veins. Ectopic glial cells are present even on those ectopic veins that have reversed polarity. (Giangrande, 1995) Extra neuron mutant. (Sturtevant and Bier, 1995) Flies have ectopic bristles on the wing surface. (Abu-Issa and Cavicchi, 1996) Homozygous clones give rise to ectopic wing vein bristles and thoracic microchaetae. (Zeng et al., 2000) h¹ animals have a higher density of notal microchaetae, however these bristles still approximately align into rows as seen in wild-type. (Renaud and Simpson, 2002) h¹ flies raised at 18^oC occasionally have ectopic bristles anterior to the anterior dorso-central bristle, while flies raised at 25^oC do not show this phenotype. (Gibert et al., 2005) When in combination with h^hs.P1 the ectopic bristle phenotype is completely suppressed. The temperature sensitive period for the bristle phenotype is 6-11 hours post-pupariation. Segmentation phenotype can be rescued by h^cosh and h^tRa, but the extra bristle phenotype cannot. (Rushlow et al., 1989)
Expression Data
Reporter Expression
Stage Tissue/Position Reference
Additional Information
Statement Reference

Assay mode
Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	gypsy{}h¹ (Hooper et al., 1989, FlyBase, 1992-)
Secondary FlyBase IDs

References ( 21 )

Generate a list of	All references relating to this insertion ( 21 )

List References by type	Research paper ( 19 ) FlyBase analysis ( 1 ) Stock list ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2006 Show research papers ...

Dmel\gypsy{}h1 Insertion

Dmel\gypsy{}h¹ Insertion