Dmel\P{EP}Nup44A^EP2417 Insertion

General Information
Symbol	Dmel\P{EP}Nup44A^EP2417	Species	D. melanogaster
Name		FlyBase ID	FBti0016421
Feature type	transposable_element_insertion_site
Description
Inserted element	P{EP}	Expression data
Affected gene(s)	Nup44A	Viability / fertility
Causes allele(s)	Nup44A^EP2417	Stock availability	1 publicly available
LINE ID	EP(2)2417
Genomic Location
Chromosomal location	2R ( 44A2 )	Sequence location	2R:3,877,204..3,877,204 [+]
Map ( GBrowse )
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)	2 (BDGP Project Members, 1994-1999)
Sequence Location	2R:3,877,204..3,877,204 [+] (BDGP Project Members, 2000-)
Orientation
Cytological location (computed by FlyBase)	44A2 ( inferred by FlyBase from sequence location )
Cytological location (reported)	43F9-43F9 (reported as inferred from sequence location) (BDGP Project Members, 2000-)
Comments concerning location
Sequence Data
Flanking sequence	AQ254859 (FlyBase, 1992-)
Inserted Element
Construct	P{EP}
Location-dependent role	mobile activating element (UASG) (Rorth, 1996)
Size	7.987Kb
Associated alleles	Scer\UAS^14x.hs TrlBR^cRa w^+mC
Molecular map
Affected Gene(s)
Insertion may affect gene	Nup44A (BDGP Project Members, 2000-, Ghosh and Feany, 2004, Senger et al., 2011)
Alleles and Phenotypes
Causes alleles	Nup44A^EP2417 (Fernandez-Funez et al., 2000, Bidet, 2003, Gene Disruption Project members, 2001-, Ghosh and Feany, 2004, Senger et al., 2011)

Lethality References
Sterility References
Phenotype Manifest In
	eye (Ghosh and Feany, 2004)
Detailed Description
Statement Reference Nup44A[EP2417]/+ partially suppresses the mio[1]/mio[2] oogenesis phenotype. In contrast to mio[1]/mio[2] single mutants, egg chambers from Nup44A[EP2417]/+, mio[1]/mio[2] females frequently progress through vitellogenesis to produce mature eggs. Moreover, a small percentage of the eggs laid by Nup44A[EP2417]/+, mio[1]/mio[2] females hatch and develop into viable adults. (Senger et al., 2011) Expression of Nup44A[EP2417] under the control of Scer\GAL4[Cha.7.4] results in a rough eye phenotype. (Ghosh and Feany, 2004) The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying Nup44A^EP2417. (Shulman and Feany, 2003) Expression of Nup44A^EP2417 under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype. (Shulman and Feany, 2003)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID	EP(2)2417 (Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 1 )
Bloomington	17053 w¹¹¹⁸; P{EP}Nup44A^EP2417
Linkouts
Comments
	Location 2R:3501512-3501513 confirmed by FlyBase alignment of dbGSS accession AQ254859 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation confirmed. (FlyBase, 2005)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	EP2417 (Fernandez-Funez et al., 2000) EP(2)2417 (Ghosh and Feany, 2004) P{EP}EP2417 (FlyBase, 1992-) P{EP}Nup44A^EP2417 (FlyBase, 2005, FlyBase, 1992-) P{EP}nup44A^EP2417 (FlyBase, 1992-)
Secondary FlyBase IDs

References ( 13 )
Research paper	Senger et al., 2011, Development 138(10): 2133--2142 The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. [FBrf0213566] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132] Ghosh and Feany, 2004, Hum. Molec. Genet. 13(18): 2011--2018 Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. [FBrf0180337] Bidet, 2003, Mech. Dev. 120(9): 991--1007 Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila. [FBrf0173131] Shulman and Feany, 2003, Genetics 165(3): 1233--1242 Genetic modifiers of tauopathy in Drosophila. [FBrf0167629] Fernandez-Funez et al., 2000, Nature 408(6808): 101--106 Identification of genes that modify ataxin-1-induced neurodegeneration. [FBrf0131287] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Rorth, 1996, Proc. Natl. Acad. Sci. USA 93(22): 12418--12422 A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. [FBrf0090768]
FlyBase analysis	FlyBase, 2005, Assessment of transgenic construct insertion sites. Assessment of transgenic construct insertion sites. [FBrf0184339] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]

Dmel\P{EP}Nup44AEP2417 Insertion

Dmel\P{EP}Nup44A^EP2417 Insertion