A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Dmel\P{EP}Edem1EP1588 Insertion

General Information
Symbol Dmel\P{EP}Edem1EP1588 Species D. melanogaster
Name FlyBase ID FBti0016575
Feature type transposable_element_insertion_site
Description
Inserted element P{EP} Expression data
Affected gene(s) Edem1 Viability / fertility
Causes allele(s) Edem1EP1588 Stock availability 1 publicly available
LINE ID EP(X)1588
Genomic Location
Chromosomal location X ( 2B15 ) Sequence location X:1,798,593..1,798,593 [+]
Map ( GBrowse ) detailed view FBti0143902 FBti0070831 FBti0013431 FBti0071691 FBti0018169 FBti0041247 FBti0047625 FBti0052900 FBti0046551 FBti0016575 FBti0071633 FBti0099752 FBti0013172 FBti0143686 FBti0132279
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Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
Chromosome (arm)
8C4 -- 8C5
(BDGP Project Members, 1994-1999)
Sequence Location
X:1,798,593..1,798,593 [+]
(BDGP Project Members, 2000-)
Orientation
Cytological location
(computed by FlyBase)
2B15 ( inferred by FlyBase from sequence location )
Cytological location
(reported)
2A3-2A3 (reported as inferred from sequence location)
(BDGP Project Members, 2000-)
Comments concerning
location
hide Sequence Data
Flanking sequence
AQ254780
(FlyBase, 1992-)
hide Inserted Element
Construct P{EP}
Location-dependent
role
mobile activating element (UASG)
(Rorth, 1996)
Size 7.987Kb
Associated alleles
Scer\UAS14x.hs
TrlBRcRa
w+mC
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
Edem1
(BDGP Project Members, 2000-, Liu et al., 2009)
hide Alleles and Phenotypes
Causes alleles
Edem1EP1588
(Gene Disruption Project members, 2001-, Liu et al., 2009)
Lethality
References
Sterility
References
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
The mean lifespan of mutant male and female flies is increased by more than 30% compared to controls. The mutant flies are longer lived than controls under both abundant and restricted food conditions. No further lifespan enhancement is seen in the mutant flies under restricted food conditions compared to abundant food conditions.
(Liu et al., 2009)
Edem1[EP1588]/α-Man-I[EP1628] and Edem1[EP1588]/α-Man-I[EP982] flies have similar lifespan profiles as α-Man-I[EP982]/α-Man-I[EP1628] flies.
(Liu et al., 2009)
hide Expression Data
Reporter Expression
Additional Information
Statement
Reference
Marker for
Reflects
expression of
hide External Images
FlyView (LinkOut)
hide Data on Genetic Line
Line ID
EP(X)1588
(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
17011
P{EP}Edem1EP1588 w1118
hide Linkouts
hide Comments
Location X:1760716-1760717 confirmed by FlyBase alignment of dbGSS accession AQ254780 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation confirmed.
(FlyBase, 2005)
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
EP1588
(Liu et al., 2009)
EP(X)1588
(FlyBase, 1992-)
P{EP}CG3810EP1588
(FlyBase, 1992-, FlyBase, 2005)
P{EP}Edem1EP1588
 
P{EP}EG:86E4.2EP1588
(FlyBase, 1992-)
P{EP}EP1588
(FlyBase, 1992-)
Secondary FlyBase IDs
hide References ( 9 )
Research paper
Liu et al., 2009, Aging Cell 8(4): 370--379
Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. [FBrf0208540]
Bellen et al., 2004, Genetics 167(2): 761--781
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Rorth, 1996, Proc. Natl. Acad. Sci. USA 93(22): 12418--12422
A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. [FBrf0090768]
FlyBase analysis
FlyBase, 2005, Assessment of transgenic construct insertion sites.
Assessment of transgenic construct insertion sites. [FBrf0184339]
FlyBase, 1992-, FlyBase curation
FlyBase curation. [FBrf0105495]
Computer file
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0125078]
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0067338]