Dmel\P{GAL4}cas³⁹²¹ Insertion

General Information
Symbol	Dmel\P{GAL4}cas³⁹²¹	Species	D. melanogaster
Name		FlyBase ID	FBti0017805
Feature type	transposable_element_insertion_site
Description
Inserted element	P{GAL4}	Expression data
Affected gene(s)	cas, Scer\GAL4	Viability / fertility
Causes allele(s)	cas³⁹²¹, Scer\GAL4^cas-3921	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	3R ( 83C1 )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
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FB2013_03
FB2013_02
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Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	83C1 ( near gene of known cytology )
Cytological location (reported)	83B--83C (in situ hybridization reported) (Hitier et al., 2001)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{GAL4}
Location-dependent role	GAL4 driver/enhancer trap (FlyBase, 1992-)
Size
Associated alleles	Scer\GAL4^unspecified
Molecular map
Affected Gene(s)
Insertion may affect gene	cas (Hitier et al., 2001) Scer\GAL4 (Kuzin et al., 2005, Kuzin et al., 2005, von Hilchen et al., 2010, Hitier et al., 2001, Beckervordersandforth et al., 2008)
Alleles and Phenotypes
Causes alleles	cas³⁹²¹ (Hitier et al., 2001) Scer\GAL4^cas-3921 (Kuzin et al., 2005, Kuzin et al., 2005, von Hilchen et al., 2010, Hitier et al., 2001, Beckervordersandforth et al., 2008)

Lethality References
Sterility References
Phenotype Manifest In
	mushroom body (Hitier et al., 2001) mushroom body beta\'-lobe (Hitier et al., 2001) mushroom body beta-lobe (Hitier et al., 2001)
Detailed Description
Statement Reference In drl^P1, cas³⁹²¹ and drl^P3.765, cas³⁹²¹ double mutants, fibres abnormally cross the midline above a flattened fan-shaped body in 55% of flies, the mushroom bodies β and β\' lobes are fully fused in 33% of flies and the ellipsoid body is ventrally cleaved. In nob^KS49/cas³⁹²¹ flies, unlike the single mutants, individuals exhibit fibres abnormally crossing the midline above the fan shaped body. (Hitier et al., 2001) Homozygotes do not have any visible defects in the adult brain. cas²⁹⁰/cas³⁹²¹ escapers reveal mushroom bodies that lack β and β\' lobes. (Hitier et al., 2001)
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS) Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16 -- 17 embryonic/larval central nervous system \| restricted (Hitier et al., 2001) pupal stage central nervous system \| restricted (Hitier et al., 2001) adult stage adult central nervous system \| restricted (Hitier et al., 2001) ellipsoid body \| restricted (Hitier et al., 2001) fan-shaped body \| restricted (Hitier et al., 2001) adult pars intercerebralis \| restricted (Hitier et al., 2001)
Additional Information
Statement Reference

Marker for
Reflects expression of
Reporter construct used in assay	Ecol\lacZ^Scer\UAS.cBa (Hitier et al., 2001)
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	cas-Gal4 (von Hilchen et al., 2010) castor-GAL4 (Kuzin et al., 2005, Kuzin et al., 2005) castor-Gal4 (Beckervordersandforth et al., 2008) Gal3921 (Hitier et al., 2001) P{GAL4}cas³⁹²¹ (Hitier et al., 2001, FlyBase, 1992-)
Secondary FlyBase IDs

References ( 6 )
Research paper	von Hilchen et al., 2010, Development 137(8): 1251--1262 Netrins guide migration of distinct glial cells in the Drosophila embryo. [FBrf0210391] Beckervordersandforth et al., 2008, Mech. Dev. 125(5-6): 542--557 Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expression. [FBrf0205499] Kuzin et al., 2005, Dev. Biol. 277(2): 347--365 Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS. [FBrf0183075] Hitier et al., 2001, Mech. Dev. 103(1-2): 3--11 The Drosophila castor gene is involved in postembryonic brain development. [FBrf0135883]
Supplementary material	Kuzin et al., 2005, Dev. Biol. 277(2): Supplemental materials. [FBrf0183076]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Dmel\P{GAL4}cas3921 Insertion

Dmel\P{GAL4}cas³⁹²¹ Insertion