A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Dmel\P{GT1}foxoBG01018 Insertion

General Information
Symbol Dmel\P{GT1}foxoBG01018 Species D. melanogaster
Name FlyBase ID FBti0018404
Feature type transposable_element_insertion_site
Description
Inserted element P{GT1} Expression data
Affected gene(s) foxo Viability / fertility viable, fertile
Causes allele(s) foxoBG01018 Stock availability 1 publicly available
LINE ID BG01018
Genomic Location
Chromosomal location 3R ( 88A5 ) Sequence location 3R:9,882,579..9,882,579 [+]
Map ( GBrowse ) detailed view FBti0021940 FBti0059115 FBti0056501 FBti0039557 FBti0055267 FBti0106568 FBti0029214 FBti0011605 FBti0104629 FBti0053360 FBti0108213 FBti0047069 FBti0055186 FBti0044147 FBti0056086 FBti0049053 FBti0018404 FBti0029020 FBti0072643 FBti0111439 FBti0040209 FBti0105240 FBti0030097 FBti0035224 FBti0066044 FBti0069953 FBti0035240 FBti0049517 FBti0076736 FBti0047433 FBti0066625 FBti0067987 FBti0065298 FBti0033861 FBti0033868
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Description
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FB2012_01
FB2011_10
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hide Detailed Mapping Data
Chromosome (arm)
Sequence Location
3R:9,882,579..9,882,579 [+]
(Gene Disruption Project members, 2001-)
Orientation
Cytological location
(computed by FlyBase)
88A5 ( inferred by FlyBase from sequence location )
Cytological location
(reported)
88A8 (reported as inferred from sequence location)
(Gene Disruption Project members, 2001-)
Comments concerning
location
hide Sequence Data
Flanking sequence
AZ933395
(Gene Disruption Project members, 2001-, FlyBase, 1992-)
hide Inserted Element
Construct P{GT1}
Location-dependent
role
GAL4 gene trap
(Lukacsovich and Asztalos, 1999.7.15)
Size 8.447, 8.447Kb
Associated alleles
Scer\GAL4GT1
Tn\neoRHsp70Bb.PS
w+mGT
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
foxo
(Dionne et al., 2006)
hide Alleles and Phenotypes
Causes alleles
foxoBG01018
(Dionne et al., 2006)
Lethality
References
viable
(Gene Disruption Project members, 2001-)
Sterility
References
fertile
(Gene Disruption Project members, 2001-)
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
foxoBG01018/foxo21 and foxoBG01018/foxo25 flies display a 4.8% improvement in medial survival following M.marinum infection in comparison to wild-type flies - 174 hours vs. 166 hours. The number of bacteria recorded in these flies is not significantly different from wild-type flies. However, the rate of glycogen loss is significantly slowed in infected foxoBG01018/foxo25 flies compared to wild-type flies, so that disease-induced wasting is reduced in the foxoBG01018/foxo25 mutants.
(Dionne et al., 2006)
hide Expression Data
Reporter Expression
Additional Information
Statement
Reference
Marker for
Reflects
expression of
hide External Images
FlyView (LinkOut)
hide Data on Genetic Line
Line ID
BG01018
(Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 1 )
Bloomington
12530
w1118; P{GT1}foxoBG01018
hide Linkouts
hide Comments
Location 3R:9882579-9882580 confirmed by FlyBase alignment of dbGSS accession AZ933395 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation confirmed.
(FlyBase, 2005)
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
BG01018
(Gene Disruption Project members, 2001-, FlyBase, 1992-, Dionne et al., 2006)
P{GT1}BG01018
(FlyBase, 2005, FlyBase, 1992-)
P{GT1}foxoBG01018
(FlyBase, 1992-)
Secondary FlyBase IDs
hide References ( 6 )
Research paper
Dionne et al., 2006, Curr. Biol. 16(20): 1977--1985
Akt and foxo dysregulation contribute to infection-induced wasting in Drosophila. [FBrf0195260]
Bellen et al., 2004, Genetics 167(2): 761--781
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
Personal communication to FlyBase
Lukacsovich and Asztalos, 1999.7.15, Dual tagging gene-trap of novel genes in Drosophila melanogaster.
Dual tagging gene-trap of novel genes in Drosophila melanogaster. [FBrf0108534]
FlyBase analysis
FlyBase, 2005, Assessment of transgenic construct insertion sites.
Assessment of transgenic construct insertion sites. [FBrf0184339]
FlyBase, 1992-, FlyBase curation
FlyBase curation. [FBrf0105495]
Computer file
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]