Dmel\P{SUPor-P}Usp7^KG06814 Insertion

General Information
Symbol	Dmel\P{SUPor-P}Usp7^KG06814	Species	D. melanogaster
Name		FlyBase ID	FBti0024590
Feature type	transposable_element_insertion_site
Description
Inserted element	P{SUPor-P}	Expression data
Affected gene(s)	Usp7	Viability / fertility
Causes allele(s)	Usp7^KG06814	Stock availability	1 publicly available
LINE ID	KG06814
Genomic Location
Chromosomal location	X ( 11A2 )	Sequence location	X:11,922,464..11,922,464 [+]
Map ( GBrowse )
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location	X:11,922,464..11,922,464 [+] (Gene Disruption Project members, 2001-)
Orientation
Cytological location (computed by FlyBase)	11A2 ( inferred by FlyBase from sequence location )
Cytological location (reported)	11A4 (reported as inferred from sequence location) (Gene Disruption Project members, 2001-)
Comments concerning location
Sequence Data
Flanking sequence	BH854629 (Gene Disruption Project members, 2001-, FlyBase, 1992-)
Inserted Element
Construct	P{SUPor-P}
Location-dependent role
Size	11.467Kb
Associated alleles	gypsy\su(Hw)BR⁴³⁰ w^BR.E.BR y^+mDint2
Molecular map
Affected Gene(s)
Insertion may affect gene	Usp7 (Gene Disruption Project members, 2001-)
Alleles and Phenotypes
Causes alleles	Usp7^KG06814 (Gene Disruption Project members, 2001-)

Lethality References lethal \| male (van der Knaap et al., 2005)
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference Females transheterozygous for Usp7^KG06814 and Pc³ show antenna to leg transformations, which are not observed in Pc³ flies. Usp7^KG06814 strongly enhances the frequency and severity of a range of homeotic transformations caused by either Pc¹ or Pc³ flies. In combination with either hetero- (females) or hemizygous (males) Pc¹ or Pc³ flies, Usp7^KG06814 significantly increases the penetrance of wing-to-haltere transformations. Depending on the combination of alleles, wing-to-haltere transformations occur in the majority or virtually all animals. Likewise, there is a strong increase in the frequency and extent of transformations of the fourth abdominal segment (A4) into the semblance of the fifth (A5), indicated by increased dark pigmentation of the A4. (van der Knaap et al., 2005) Usp7^KG06814 is a lethal mutation in males and homozygous lethal in females. (van der Knaap et al., 2005)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID	KG06814 (Gene Disruption Project members, 2001-)
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 1 )
Bloomington	14505 y¹ P{SUPor-P}Usp7^KG06814/FM7c
Linkouts
Comments
	Location X:11862368-11862369 confirmed by FlyBase alignment of dbGSS accession BH854629 to D. melanogaster arm Release_4 and heterochromatin Release_3.2b. Insertion orientation revised. (FlyBase, 2005)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	KG06814 (Gene Disruption Project members, 2001-, FlyBase, 1992-) P{SUPor-P}CG1490^KG06814 (FlyBase, 1992-, FlyBase, 2005) P{SUPor-P}Usp7^KG06814 (FlyBase, 1992-)
Secondary FlyBase IDs

References ( 6 )
Research paper	van der Knaap et al., 2010, Mol. Cell. Biol. 30(3): 736--744 Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes. [FBrf0209736] van der Knaap et al., 2005, Molec. Cell 17(5): 695--707 GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. [FBrf0184151] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
FlyBase analysis	FlyBase, 2005, Assessment of transgenic construct insertion sites. Assessment of transgenic construct insertion sites. [FBrf0184339] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]

Dmel\P{SUPor-P}Usp7KG06814 Insertion

Dmel\P{SUPor-P}Usp7^KG06814 Insertion