A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Dmel\?{}gt1a Insertion

General Information
Symbol Dmel\?{}gt1a Species D. melanogaster
Name FlyBase ID FBti0025340
Feature type transposable_element_insertion_site
Description
Inserted element ?{} Expression data
Affected gene(s) gt Viability / fertility
Causes allele(s) gt1 Stock availability none publicly available
LINE ID
Genomic Location
Chromosomal location X ( 3A3 ) Sequence location
Member of Large Scale Dataset(s)
Dataset
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Description
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What does this section not display?
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location
(computed by FlyBase)
3A3 ( near gene of known cytology )
Cytological location
(reported)
Comments concerning
location
hide Sequence Data
Flanking sequence
hide Inserted Element
Construct ?{}
Location-dependent
role
Size
Associated alleles
Molecular map
hide Affected Gene(s)
Insertion may
affect gene
gt
(Lindsley and Zimm, 1992, Parrish et al., 2009)
hide Alleles and Phenotypes
Causes alleles
gt1
(Lindsley and Zimm, 1992, Parrish et al., 2009)
Lethality
References
viable
 
Sterility
References
hide Phenotype Manifest In
larval salivary gland & embryo & nuclear chromosome
(Bridges, 1935)
prothoracic gland | third instar larval stage
(Ghosh et al., 2010)
prothoracic gland innervating neuron PG-LP | third instar larval stage
(Ghosh et al., 2010)
hide Detailed Description
Statement
Reference
gt[1] larvae exhibit a prolonged third instar stage in 25% of females and 13% of male animals. Larvae and pupae are significantly larger than control animals. In gt[1] larval brains, unilateral inneration of the prothoracic gland is observed, and an asymmetrically sized gland is observed in which the innervated portion is significantly larger than the non-innervated side. Cells on the non-innervated side contain nuclei that are significantly smaller compared to the innervated side. There is an increase in the frequency of axon misrouting in gt[1] mutant larvae in the prothoracic gland. gt[1] mutants containing one or two prothoracic gland neurons in one of the brain lobes often show branching of axons at the base of the ring gland and innervation of both prothoracic glands. Similar branching defects are also observed in mutant brains where all four prothoracic gland neurons are present.
(Ghosh et al., 2010)
Delayed pupariation and enlarged larvae, pupae and adults.
(Mohler et al., 1989)
gtQ292/gt1 larvae show a reduction in the normal inhibition of DNA synthesis following treatment with N-acetoxy-2-acetylaminofluorene. gt13z/gt1 larvae do not have a defect in the repair of X-ray induced DNA breaks.
(Narachi and Boyd, 1985)
Salivary gland chromosomes are double normal thickness in some cells.
(Bridges, 1935)
Larval development is 4 days longer than normal, resulting in giant larvae, pupae, and imagos. Adult weight is 1.7 times normal. Not all genetically gt flies show the giant character, the rest have normal size. The distribution is sharply bimodal. The percentage of phenotypically giant animals is greatest in well-fed cultures, and is also raised by the modifying action of bb11. RK3.
 
hide Expression Data
Reporter Expression
Additional Information
Statement
Reference
Marker for
Reflects
expression of
Reporter construct
used in assay
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FlyView (LinkOut)
hide Data on Genetic Line
Line ID
Origin as a multiple insertion line
hide Progenitor(s) within the Genome
hide Related Aberration or Balancer
Aberration
Balancer
hide Stocks ( 0 )
hide Linkouts
hide Comments
One of two insertions associated with this allele; see ?{}gt1b.
(FlyBase, 1992-)
hide Synonyms & Secondary IDs
Reported As
Symbol Synonym
?{}?{}gt1
(FlyBase, 1992-)
?{}gt1a
(FlyBase, 1992-, Lindsley and Zimm, 1992)
FBti0014474
(FlyBase, 1992-)
unnamed
(Parrish et al., 2009)
Secondary FlyBase IDs
hide References ( 7 )
Research paper
Ghosh et al., 2010, Dev. Biol. 347(2): 271--278
The Drosophila gap gene giant regulates ecdysone production through specification of the PTTH-producing neurons. [FBrf0212090]
Parrish et al., 2009, Neuron 63(6): 788--802
The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. [FBrf0208858]
Mohler et al., 1989, EMBO J. 8: 1539--1548
A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila. [FBrf0049604]
Narachi and Boyd, 1985, Mol. Gen. Genet. 199: 500--506
The giant (gt) mutants of Drosophila melanogaster alter DNA metabolism. [FBrf0043261]
Bridges, 1935, J. Hered. 26: 60--64
Salivary chromosome maps with a key to the banding of the chromosomes of Drosophila melanogaster. [FBrf0003150]
FlyBase analysis
FlyBase, 1992-, FlyBase curation.
FlyBase curation. [FBrf0105495]
Book
Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
The Genome of Drosophila melanogaster. [FBrf0066905]