|Inserted element||P-element||Expression data|
|Affected gene(s)||lawc||Viability / fertility|
|Causes allele(s)||lawcp1||Stock availability||none publicly available|
|Chromosomal location||X ( 7E6-7E7 )||Sequence location|
|Member of Large Scale Dataset(s)|
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|Detailed Mapping Data|
(computed by FlyBase)
7E6-7E7 ( near gene of known cytology )
|Alleles and Phenotypes|
partially lethal - majority die | recessive
|Phenotype Manifest In|
adult thorax & macrochaeta
macrochaeta | ectopic
The arista-to-leg transformation seen in lawc[p1] flies is reduced in frequency by 75% if they are also carrying lawc[t6.5]. lawc[t6.5] also rescues the lethality of lawc[p1]. The ability of lawc[p1] to enhance the cut wing phenotype of ct[n] is partially suppressed by lawc[t6.5]; there is a 44% in the frequency of lawc[p1] ct[n] flies with very cut wings if they are also carrying lawc[t6.5].
35-65% of mutant larvae survive to adulthood. Mutants show an arista-to-leg transformation.
Pros26[unspecified]/+ significantly enhances the arista-to-leg transformation seen in lawc[p1] mutants.
Phenotype similar to that of the lost alleles scr1 and bwl1 with respect to wing and bristle phenotypes, but differs in showing homeotic transformation arista to tarsus not described for scr1 and bwl1.
Does not enhance the frequency of homeotic transformations of trxB11, brm2 or ash117 single heterozygotes. The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in trxB11 ash117 or brm2 trxE2 double heterozygotes is dominantly enhanced by lawcp1. The enhancement is stronger in a lawcp1 maternal background. The arista to leg transformation characteristic of lawcp1 is also enhanced in these flies. lawcp1/lawcEF520 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/lawcEF520 results in lethality. lawcp1/Df(1)RA2 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/Df(1)RA2 results in lethality. The ectopic sex combs seen on the second and/or third legs of Df(3L)Pc-MK/+ or Pc4/+ males are largely suppressed by lawcp1. Body colour: the abdominal pigment of y2 males is lighter than normal, but uniformly distributed in the last two abdominal segments. y2; mod(mdg4)ul males have variegated abdominal pigmentation with individual spots of wild-type dark pigment against a lighter pigmented background in the last two abdominal segments. This variegated phenotype is suppressed if the flies are also carrying lawcp1; the areas of lighter pigmentation increase at the expense of darkly pigmented regions so that the phenotype is closer to y2 rather than y2 ; mod(mdg4)ul flies.
All lawcp1 flies show partial transformation of the arista into leg, which is manifested as a thickening of the arista. 1% of flies show complete transformation into leg, such that leg segments and tarsal claws are seen instead of arista tissue. Flies often have ectopic bristles on the scutellum and thorax, and the wings are held apart with multiple incisions in the margins, especially along the posterior margin. The mutant phenotype is stronger in males than females. Most lawcp1/Df(1)RA2 females die as early larvae. The 10% that do eclose have an enhanced lawc mutant phenotype compared to lawcp1 flies that includes strong arista to leg transformation, many ectopic bristles and larger wing margin incisions. The 3% of lawcEF520/lawcp1 females that eclose have an enhanced lawc mutant phenotype compared to lawcp1 flies that includes an arista to leg transformation.
Temperature sensitive periods for the formation of extra macrochaetae are distributed within larval instars II and III. Different types of macrochaetae differ from one another in their temperature sensitivity.
Phenotype is 1% penetrant for complete transformation of arista to leg and fully penetrant for partial transformation, i.e. thickened aristae. Occasionally extra bristles appear on the thorax and scutellum, the wings are hyper-extended with incisions in their margins and the abdominal markings are abnormal.
used in assay
|Data on Genetic Line|
|Origin as a multiple insertion line|
|Progenitor(s) within the Genome|
|Related Aberration or Balancer|
|Stocks ( 0 )|
|Synonyms & Secondary IDs|
|Secondary FlyBase IDs|
|References ( 8 )|
|Personal communication to FlyBase||