Dmel\P{}sn^wa Insertion

General Information
Symbol	Dmel\P{}sn^wa	Species	D. melanogaster
Name		FlyBase ID	FBti0025355
Feature type	transposable_element_insertion_site
Description
Inserted element	P-element	Expression data
Affected gene(s)	sn	Viability / fertility
Causes allele(s)	sn^w	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location	X ( 7D1-7D2 )	Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	7D1-7D2 ( near gene of known cytology )
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P-element
Location-dependent role
Size
Associated alleles
Molecular map
Affected Gene(s)
Insertion may affect gene	sn (Roiha et al., 1988)
Alleles and Phenotypes
Causes alleles	sn^w (Collins et al., 1983, Lindsley and Zimm, 1992, Simmons et al., 2002, Biryukova et al., 1999, Rio, 1990, Georgiev and Gerasimova, 1989, Brookfield and Lewis, 1989, Rasmusson et al., 1990, Simmons et al., 1990, Daniels et al., 1990, Ronsseray et al., 1996, Henderson and Glover, 1998, Roiha et al., 1988)

Lethality References
Sterility References female fertile (Lindsley and Zimm, 1992)
Phenotype Manifest In
	macrochaeta (Lindsley and Zimm, 1992) microchaeta (Lindsley and Zimm, 1992)
Detailed Description
Statement Reference The viability of Mnn1^e200 mutants (Df(2L)Mnn1^e200 mutants in which milt function is rescued by expression of the milt⁺²² transgene) is not affected by a sn^w background. (Busygina et al., 2004) Bristle phenotype is suppressed by su(s)⁷¹, and partly suppressed by su(s)^sn-w:R. (Merriman et al., 1995) Repression potential of a P-element repressor protein in a singed sterility assay of sn^w/sn^X2 heterozygotes shows partial correspondence with gonadal dysgenic sterility in that strong repression of gonadal dysgenic sterility shows some effect in the singed sterility assay. (Misra et al., 1993) Weak singed phenotype, probably class 2. Highly mutable in dysgenic genotypes; 40% to 60% of offspring are either normal (sn⁽⁺⁾) or extreme singed (sn^e) in phenotype. These derivatives are in turn mutable, but at much lower levels. Completely stable in non-dysgenic genotypes. Gnarled macrochaetae and kinky microchaetae. (Lindsley and Zimm, 1992) The presence of P\T⁶⁶ causes a drastic reduction in destabilisation of sn^w to sn^e or sn⁽⁺⁾. This repression is not increased by P\T^66D1.hs, but it is increased by P\T^66C2.hs. (Misra and Rio, 1990) Can mutate during a dysgenic cross to either wild type phenotype or a more extreme (sn^e) bristle phenotype depending on which one of the P-elements excises. (Rio, 1990) Phenotype is unaffected by mod(mdg4)^ul. (Georgiev and Gerasimova, 1989)
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Reporter construct used in assay
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Comments
	One of two P-element insertions associated with this allele; see P{}sn^wb. (FlyBase, 1992-)
Synonyms & Secondary IDs
Reported As
Symbol Synonym	FBti0014672 (FlyBase, 1992-) P{}P{}sn^w (FlyBase, 1992-) P{}sn^wa (FlyBase, 1992-, Roiha et al., 1988)
Secondary FlyBase IDs

References ( 18 )
Research paper	Busygina et al., 2004, Hum. Mol. Genet. 13(20): 2399--2408 Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. [FBrf0180339] Simmons et al., 2002, Genetics 161(1): 195--204 A hobo transgene that encodes the P-element transposase in Drosophila melanogaster: autoregulation and cytotype control of transposase activity. [FBrf0149013] Biryukova et al., 1999, Genetics 152(4): 1641--1652 The P-Ph protein-mediated repression of yellow expression depends on different cis- and trans-factors in Drosophila melanogaster. [FBrf0109352] Henderson and Glover, 1998, Mutagenesis 13(1): 57--60 Chromosome fragmentation resulting from an inability to repair transposase-induced DNA double-strand breaks in PCNA mutants of Drosophila. [FBrf0100571] Ronsseray et al., 1996, Genetics 143(4): 1663--1674 The regulatory properties of autonomous subtelomeric P elements are sensitive to a Suppressor of variegation in Drosophila melanogaster. [FBrf0089801] Merriman et al., 1995, Genetics 141(4): 1425--1438 S elements: A family of Tc1-like transposons in the genome of Drosophila melanogaster. [FBrf0085576] Misra et al., 1993, Genetics 135(3): 785--800 Cytotype control of Drosophila melanogaster P element transposition: genomic position determines maternal repression. [FBrf0065495] Daniels et al., 1990, Genetics 124(2): 339--355 Evidence for horizontal transmission of the P transposable element between Drosophila species. [FBrf0051937] Misra and Rio, 1990, Cell 62: 269--284 Cytotype control of Drosophila P element transposition: the 66 kd protein is a repressor of transposase activity. [FBrf0051364] Rasmusson et al., 1990, Genetics 124: 647--662 Quantitative effects of P-elements on hybrid dysgenesis in Drosophila melanogaster. [FBrf0051965] Simmons et al., 1990, Genetics 124: 663--676 Repression of P-element-mediated hybrid dysgenesis in Drosophila melanogaster. [FBrf0051968] Brookfield and Lewis, 1989, Genet. Res. (Camb.) 54: 101--112 Somatic reversion of P transposable element insertion mutations in the singed locus of Drosophila melanogaster requiring specific P insertions and a trans-acting factor. [FBrf0049839] Georgiev and Gerasimova, 1989, Mol. Gen. Genet. 220: 121--126 Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster. [FBrf0050555] Roiha et al., 1988, Genetics 119: 75--83 P element insertions and rearrangements at the singed locus of Drosophila melanogaster. [FBrf0048245] Collins et al., 1983, Yb. Carnegie Instn, Wash. 82: 180--182 Transposable genetic elements and the white locus of Drosophila. [FBrf0063381]
Review	Rio, 1990, A. Rev. Genet. 24: 543--578 Molecular mechanisms regulating Drosophila P-element transposition. [FBrf0051102]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Dmel\P{}snwa Insertion

Dmel\P{}sn^wa Insertion