Dmel\P{GawB}2-21 Insertion

General Information
Symbol	Dmel\P{GawB}2-21	Species	D. melanogaster
Name		FlyBase ID	FBti0128084
Feature type	transposable_element_insertion_site
Description
Inserted element	P{GawB}	Expression data	GAL4 reporter/driver
Affected gene(s)	Scer\GAL4	Viability / fertility
Causes allele(s)	Scer\GAL4^2-21	Stock availability	none publicly available
LINE ID
Genomic Location
Chromosomal location		Sequence location
Member of Large Scale Dataset(s)
Dataset
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)
Cytological location (reported)
Comments concerning location
Sequence Data
Flanking sequence
Inserted Element
Construct	P{GawB}
Location-dependent role	GAL4 driver/enhancer trap (Brand and Perrimon, 1993)
Size	11.279Kb
Associated alleles	Scer\GAL4^wB w^+mW.hs
Molecular map
Affected Gene(s)
Insertion may affect gene	Scer\GAL4 (Zheng et al., 2008, Hughes and Thomas, 2007, Cheng et al., 2010, Mazock et al., 2010, Shimono et al., 2009, Hwang et al., 2007, Tsubouchi et al., 2012)
Alleles and Phenotypes
Causes alleles	Scer\GAL4^2-21 (Zheng et al., 2008, Hughes and Thomas, 2007, Cheng et al., 2010, Mazock et al., 2010, Shimono et al., 2009, Hwang et al., 2007, Tsubouchi et al., 2012)

Lethality References
Sterility References
Phenotype Manifest In

Detailed Description
Statement Reference
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS) Stage Tissue/Position (including subcellular localization) Reference larval stage class I dendritic arborizing neuron (Cheng et al., 2010) bipolar dendrite neuron (Cheng et al., 2010) third instar larval stage bipolar dendrite neuron \| subset (Hughes and Thomas, 2007) class I dendritic arborizing neuron \| subset (Hughes and Thomas, 2007) abdominal dorsal bipolar neuron dbp (Hughes and Thomas, 2007) abdominal dorsal multidendritic neuron ddaD (Hughes and Thomas, 2007) abdominal dorsal multidendritic neuron ddaE (Hughes and Thomas, 2007) abdominal posterior ventral multidendritic neuron vdap (Hughes and Thomas, 2007) embryonic/larval brain \| restricted (Hughes and Thomas, 2007) ventral nerve cord \| restricted (Hughes and Thomas, 2007) class I dendritic arborizing neuron (Tsubouchi et al., 2012)
Additional Information
Statement Reference Scer\GAL4[2-21] drives expression in some neurons in the PNS including class I dendritic arborizing neurons (ddaD, ddaE and vdap) and in the longitudinal bipolar dendrite neurons (dbp). Labelling is also seen in a few cells in the brain and ventral nerve cord. (Hughes and Thomas, 2007, Hughes and Thomas, 2007)

Marker for
Reflects expression of
Reporter construct used in assay	Avic\GFP^Mhc-C110 (Hughes and Thomas, 2007) Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} (Hughes and Thomas, 2007, Tsubouchi et al., 2012) nompC^L.Scer\UAS (Cheng et al., 2010)
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 0 )

Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	2-21 (Hughes and Thomas, 2007, Shimono et al., 2009) 2-21-Gal4 (Zheng et al., 2008, Mazock et al., 2010) 2-21-GAL4 (Tsubouchi et al., 2012, Hwang et al., 2007) bd/I-Gal4 (Cheng et al., 2010) P{GawB}2-21 (FlyBase, 1992-)
Secondary FlyBase IDs

References ( 9 )
Research paper	Tsubouchi et al., 2012, Curr. Biol. 22(22): 2124--2134 Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae. [FBrf0219946] Cheng et al., 2010, Neuron 67(3): 373--380 The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion. [FBrf0211468] Mazock et al., 2010, Mol. Biol. Cell 21(16): 2860--2868 Transgene Rescue Identifies an Essential Function for Drosophila {beta} Spectrin in the Nervous System and a Selective Requirement for Ankyrin-2-binding Activity. [FBrf0211527] Shimono et al., 2009, Neural Dev. 4: 37 Multidendritic sensory neurons in the adult Drosophila abdomen: origins, dendritic morphology, and segment- and age-dependent programmed cell death. [FBrf0209127] Zheng et al., 2008, Nat. Cell Biol. 10(10): 1172--1180 Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. [FBrf0206898] Hughes and Thomas, 2007, Mol. Cell. Neurosci. 35(2): 383--396 A sensory feedback circuit coordinates muscle activity in Drosophila. [FBrf0201151] Hwang et al., 2007, Curr. Biol. 17(24): 2105--2116 Nociceptive neurons protect Drosophila larvae from parasitoid wasps. [FBrf0200914] Brand and Perrimon, 1993, Development 118(2): 401--415 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. [FBrf0064375]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]