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General Information
Symbol
UAS
FlyBase ID
FBto0000180
Name
Upstream activation sequence
Description
Description
The UAS upstream activation sequence contains varying numbers of a 17bp repeat that is specifically bound by the DNA-binding domain of the Saccharomyces cerevisiae GAL4 gene ( SGDID:S000006169 ) (PMID:3886158). GAL4 binds as a dimer to the UAS regulatory sequence, resulting in transcriptional activation of a downstream gene (reviewed in FBrf0233764). This property can be utilized to form a binary expression system to control the spatial and temporal expression of a gene of interest: a transgene or modified endogenous locus in which the target gene of interest is downstream of UAS sequences can be combined with a transgene or modified endogenous locus encoding any 'driver' that includes the GAL4 DNA-binding domain plus a transcriptional activation sequence (FBrf0064375, also reviewed in FBrf0233764, FBrf0216478).
External Crossreferences and Linkouts
Related experimental tools
Transgenic Constructs
Has tool as regulatory region (27019)
Transgenic construct(s)
Component allele
Reg. region
Encoded product / tool
Tagged with
Also carries
Stocks
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Insertions ( 18,234 )
Insertion
Encoded product / tool
Tagged with
Also carries
Stocks
Associated Alleles
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Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Scer\UAS
UAS
Name Synonyms
Upstream activation sequence
Secondary FlyBase IDs
  • FBgn0015319
References (4,463)